Sigmastat

Manufactured by Grafiti LLC

Sourced in United States, Germany, United Kingdom, Holy See (Vatican City State)

SigmaStat is a statistical software package designed for data analysis. It provides a range of statistical tests and procedures to help users analyze and interpret their research data.

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Lab products found in correlation

Sigmaplot, by Grafiti LLC (32 mentions) Pclamp software, by Molecular Devices (7 mentions) Prism 5, by GraphPad (6 mentions) Prism software, by GraphPad (5 mentions) Prism 6, by GraphPad (5 mentions) Quatropro, by Corel (4 mentions) Sigmaplot 13, by Grafiti LLC (4 mentions) Statistica, by StatSoft (4 mentions) Prism 8, by GraphPad (3 mentions) Matlab, by MathWorks (2 mentions) Stat200, by Biosoft (2 mentions) Systat, by Grafiti LLC (2 mentions) Sigmaplot 14, by Grafiti LLC (2 mentions) Axopatch 200a amplifier, by Molecular Devices (2 mentions) Trizol reagent, by Thermo Fisher Scientific (2 mentions) Spss statistics for window, by IBM (2 mentions) Prism v6, by GraphPad (2 mentions) R software, by R Project for Statistical Computing (1 mentions) Jmp version 8, by SAS Institute (1 mentions) Spss v14, by IBM (1 mentions)

Close spelling variants of this product

SigmaStat 3.5 (619 citations) SigmaStat 11.0 (28 citations) SigmaStat 2.0 (22 citations) SigmaStat software version 3.5 (21 citations) SigmaStat statistical software (15 citations) SigmaStat version 2.03 (10 citations) SigmaStat version (7 citations) SigmaStat version 3.5 for Windows (6 citations) SigmaStat 3.0 for Windows (6 citations) Sigmastat statistical program Version 11.2 (5 citations)

577 protocols using sigmastat

Evaluating Cognitive Outcomes in Mice

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Results are reported as mean ± standard error (SE). Data was analyzed using two-way repeated measure ANOVAs, and Bonferroni corrected t-tests were used for post hoc analyses (SigmaStat, Systat Software, Inc.). Statistical tests were performed using SigmaStat software (Systat Software Inc.), and alpha levels were set at 0.05, with only significant effects reported.

Du C., Park K., Allen C.P., Hu X.T., Volkow N.D, & Pan Y. (2021). Ca2+ channel blockade reduces cocaine’s vasoconstriction and neurotoxicity in the prefrontal cortex. Translational Psychiatry, 11, 459.

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Transcriptomic and Lipidomic Analysis of Human Meibum

Cited 1 time

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The transcriptomic datasets were processed using Expression and Transcriptome Analysis Consoles (v.4.0.1.36; both from Affymetrix) and SigmaStat (v.3.5, from Systat Software, Inc., San Jose, CA, USA). The default (and currently the industry standard) filter criteria: (1) (+2) < LFC < (−2), and (2) ANOVA p-value (condition pair) ≤0.05, were used to analyze the data. A tighter LFC of >(+1.2) and <(−1.2), as proposed in [34 (link)], was also tested, but deemed impractical because of an unrealistically high number of samples needed to satisfy statistical criteria (see Discussion).
The RP-UPLC/MS data were analyzed using MassLynx (v.4.1), MSe Data Viewer (v.1.4), and Progenesis QI software packages (from Waters). A Supplemental Table S1 lists major lipids of human meibum relevant to this study, and their corresponding m/z values. SigmaStat and SigmaPlot software packages from Systat Software, Inc. were used to conduct statistical evaluation of the data.
The transcriptomic and lipidomic data for two genders were compared gender-wide using Student’s t-test for the two groups. Tests with p-values ≤ 0.05 were considered statistically significant. Principal component analyses were performed using Transcriptome Analysis Console, Progenesis QI, and EZInfo (v.3.0.3.0 from Umetrics AB, Umeå, Sweden).

Butovich I.A., Bhat N, & Wojtowicz J.C. (2019). Comparative Transcriptomic and Lipidomic Analyses of Human Male and Female Meibomian Glands Reveal Common Signature Genes of Meibogenesis. International Journal of Molecular Sciences, 20(18), 4539.

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Statistical Analysis of Experimental Data

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All experimental data are presented in the text and graphs as the mean ± SEM. Statistical analysis were carried out using one way analysis of variance (ANOVA) when comparing multiple treatment groups (SigmaStat, Systat Software Inc., Richmond, VA). A repeated-measures analysis of variance (ANOVA) was performed for the time-course of the changes in Figs. 3, 4, 5 and 6 utilizing SigmaPlot 14 (SigmaStat, Systat Software Inc., Richmond, VA). Where necessary, post-hoc Newman-Keuls tests were performed for planned comparisons. The unpaired Students t-test was used when there were only two groups to be compared such as the experiment to transfact BDNF cDNA for the expression of TH and pERK1/2 (Fig. 6).

Zhu M.Y., Raza M.U., Zhan Y, & Fan Y. (2019). Norepinephrine upregulates the expression of tyrosine hydroxylase and protects dopaminegic neurons against 6-hydrodopamine toxicity.. Neurochemistry international, 131, 104549.

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Statistical Analysis of Cell Culture

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Culture experiments were tested for normal distribution and equal variance before being compared to controls by ANOVA, followed by Student Newman–Keuls test to determine where any differences lay. p < 0.05 values were considered statistically significant. Analyses were performed using SigmaStat version 3.5 (Systat Software, Inc., San Jose, CA) and data have been expressed as mean ± SD.

McCabe M.J., Hu Y., Gregory L.C., Gaston-Massuet C., Alatzoglou K.S., Saldanha J.W., Gualtieri A., Thankamony A., Hughes I., Townshend S., Martinez-Barbera J.P., Bouloux P.M, & Dattani M.T. (2015). Novel application of luciferase assay for the in vitro functional assessment of KAL1 variants in three females with septo-optic dysplasia (SOD). Molecular and Cellular Endocrinology, 417, 63-72.

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Quantitative Analysis of Protein Levels

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All experiments were performed at least three times. All data are expressed as means±standard deviations. Statistical analysis was performed using Sigma Stat (Systat Software, La Jolla, CA, USA). Data in which two conditions were compared were evaluated using one-way analysis of variance followed by Tukey's post-hoc test; p-values <0.05 were considered significant.

Kang M.W., Song H.J., Kang S.K., Kim Y., Jung S.B., Jee S., Moon J.Y., Suh K.S., Lee S.D., Jeon B.H, & Kim C.S. (2015). Nafamostat Mesilate Inhibits TNF-α-Induced Vascular Endothelial Cell Dysfunction by Inhibiting Reactive Oxygen Species Production. The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, 19(3), 229-234.

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Statistical Analysis of Experimental Data

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All data are reported as mean values ± sem. Statistical differences between treatment and control groups were evaluated by Sigma Stat (Systat Software, London, UK). Both parametric and non-parametric analyses were applied, in which the Mann–Whitney rank sum test (Mann–Whitney U-test) was used for samples on a non-normal distribution, whereas a two-tailed t-test was performed for samples with a normal distribution.

Guo Z., Jing R., Rao Q., Zhang L., Gao Y., Liu F., Wang X., Hui L, & Yin H. (2018). Immortalized common marmoset (Callithrix jacchus) hepatic progenitor cells possess bipotentiality in vitro and in vivo. Cell Discovery, 4, 23.

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Cardiac and Exercise Hemodynamics Analysis

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A 1-way analysis of variance (ANOVA) was used to determine group differences in participant characteristics, LV structure and function and BV variables and for parametric data Bonferroni’s t-test post hoc testing was used when the ANOVA resulted in a p <0.05 result. Non-parametric data were analyzed via Kruskal-Wallis ANOVA on ranks, with Dunn’s post hoc testing. Repeated-measures (RM) ANOVAs were used to determine group differences in exercise metabolic and hemodynamics variables. When the main group effect achieved p < 0.05, Bonferroni post hoc tests were performed to examine group differences at the different experimental conditions. All statistical analyses were performed using SigmaStat (Systat Software) and p <0.05 was considered statistically significant. Data are presented as means ± SD or median (25% - 75%) in Tables 1–5 and means ± SD in Figs 1-4.

Carrick-Ranson G., Sloane N.M., Howden E.J., Bhella P.S., Sarma S., Shibata S., Fujimoto N., Hastings J.L, & Levine B.D. (2020). The Effect of Lifelong Endurance Exercise on Cardiovascular Structure and Exercise Function in Women. The Journal of physiology, 598(13), 2589-2605.

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Statistical Analysis of Experimental Data

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Statistical analysis was performed using SigmaStat (Systat Software, San Jose, CA, USA) and data were visualized using GraphPad Prism (La Jolla, CA, USA). Comparisons between groups were performed with Student’s t-tests. If comparisons failed normality tests then Mann–Whitney rank sum tests were performed. Pearson’s correlations were performed to determine linear correlation between two groups. Significance was set at p < 0.05.

Bohnsack J.P., Teppen T., Kyzar E.J., Dzitoyeva S, & Pandey S.C. (2019). The lncRNA BDNF-AS is an epigenetic regulator in the human amygdala in early onset alcohol use disorders. Translational Psychiatry, 9, 34.

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Comprehensive Statistical Analysis Protocol

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Results are expressed as the mean ± SEM. Two-group analyses were performed using an unpaired t-test. Three or more groups with one independent variable were analyzed using a one-way ANOVA test. Three or more groups with two independent variables were analyzed using a two-way ANOVA test. Analyses were performed using the Prism (GraphPad Software, San Diego, CA, USA) and SigmaStat (SyStat Software, Inc., San Jose, CA, USA) software packages. All tests were two-tailed and a p-value < 0.05 was considered to indicate statistical significance.

Cao S., Wang Y., Zhou Y., Zhang Y., Ling X., Zhang L., Li J., Yang Y., Wang W., Shurin M.R, & Zhong H. (2022). A Novel Therapeutic Target for Small-Cell Lung Cancer: Tumor-Associated Repair-like Schwann Cells. Cancers, 14(24), 6132.

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Statistical Analysis of Biomarker Associations

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SigmaStat (Systat Software, Chicago, IL, USA) software was used for statistical analyses. Differences between the three groups were analyzed using Kruskal–Wallis one way analysis of variance on ranks. Spearman rank order correlation analysis was used to find associations between the markers. Criteria for significance were set at p<0.05 for all parameters.

Vengerfeldt V., Mändar R., Saag M., Piir A, & Kullisaar T. (2017). Oxidative stress in patients with endodontic pathologies. Journal of Pain Research, 10, 2031-2040.

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