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L lactide la

Manufactured by Boehringer Ingelheim
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L-Lactide (LA) is a cyclic ester compound used as a starting material for the production of polylactic acid (PLA) and other related polymers. It is a white crystalline solid with the chemical formula C6H8O4. L-Lactide is the primary precursor for the synthesis of biodegradable and biocompatible polymers, which have various applications in the medical and pharmaceutical industries.

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Lab products found in correlation

ε caprolactone cl, by Merck Group (1 mentions) Sn oct 2, by Merck Group (1 mentions) Dexamethasone (dex), by Tokyo Chemical Industry (1 mentions) Ir783, by Merck Group (1 mentions)

2 protocols using l lactide la

1

MPEG-based Polymer Synthesis

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The methoxy poly(ethylene glycol) (MPEG) (number-average molecular weight (Mn = 750), and Sn(Oct)2 (Aldrich, Yongin, Korea) were used as received. ε-Caprolactone (CL) was distilled over CaH2 under reduced pressure. l-Lactide (LA; Boehringer Ingelheim, Blanquefort, France) was recrystallized twice in ethyl acetate. Dexamethasone (Dex(b)) and dexamethasone 21-phosphate disodium salt (Dex(s)) were purchased from TCI (Tokyo, Japan) and Sigma-Aldrich (St. Louis, MO, USA), respectively.
Lee J.W., Lee H.Y., Park S.H., Park J.H., Kim J.H., Min B.H, & Kim M.S. (2016). Preparation and Evaluation of Dexamethasone-Loaded Electrospun Nanofiber Sheets as a Sustained Drug Delivery System. Materials, 9(3), 175.
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2

Synthesis of MPEG-based Copolymers

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Methoxy poly(ethylene glycol) (MPEG) (Sigma-Aldrich, number-average molecular weight (Mn = 750)), and Sn(Oct)2 (Sigma-Aldrich, Yongin, Korea) were used as received. l-lactide (LA; Boehringer Ingelheim, Blanquefort, France) was recrystallized in ethyl acetate twice. ε-Caprolactone (CL; Sigma-Aldrich) was distilled over CaH2 under reduced pressure. Dex and Dex(p) were purchased from Tokyo Chemical Industry Co., Ltd. (TCI; Fukaya City, Japan). Hexafluoro-2-propanol (HFIP), IR-780, and IR-783 were purchased from Sigma-Aldrich.
Park J.H., Lee B.K., Park S.H., Kim M.G., Lee J.W., Lee H.Y., Lee H.B., Kim J.H, & Kim M.S. (2017). Preparation of Biodegradable and Elastic Poly(ε-caprolactone-co-lactide) Copolymers and Evaluation as a Localized and Sustained Drug Delivery Carrier. International Journal of Molecular Sciences, 18(3), 671.
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