Trimetazidine

Manufactured by Cayman Chemical

Sourced in United States

Trimetazidine is a chemical compound used in the production of pharmaceutical and research products. It is a heterocyclic compound with a molecular formula of C14H21NO3. Trimetazidine serves as a key intermediate in the synthesis of various medications and research materials.

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Lab products found in correlation

2 protocols using trimetazidine

Lipid Metabolism Inhibitor Compounds

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VPS34 IN-1 (#17392), PIK-III (#17002), Triacsin C (#10007448), Orlistat (#10005426), TOFA (#10005263), C75 (#10005270), Etomoxir (#11969), Trimetazidine (#18165), and A-922500 (#10012708) were purchased from Cayman Chemical (Ann Arbor, Michigan, USA). Remdesivir was purchased from Target Molecule Corp. (T7766, Boston, Massachusetts, USA). 2-bromopalmitate was purchased from Sigma-Aldrich (#21604, St. Louis, MO, USA). All compounds were resuspended in dimethylsulfoxide (DMSO).

Williams C.G., Jureka A.S., Silvas J.A., Nicolini A.M., Chvatal S.A., Carlson-Stevermer J., Oki J., Holden K, & Basler C.F. (2021). Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication. Cell Reports, 36(5), 109479.

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Mitochondrial Dysfunction Assays

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FAO inhibitors used in the study were etomoxir (catalog no. 4539; Tocris Bioscience), trimetazidine (catalog no. 18165; Cayman Chemical Company), and oxfenicine (catalog no. 56160; Millipore Sigma). Metformin (catalog no. D150959), mitoTEMPO (catalog no. SML0737), diphenyleneiodonium chloride (DPI) (catalog no. D2926), N-acetyl cysteine (NAC) (catalog no. A7250), tert-butylhydroperoxide (tBHP) (catalog no. 416665), amikacin (catalog no. A1774), phorbol 12-myristate 13-acetate (PMA) (catalog no. P8139), rapamycin (catalog no. R0395), rotenone (catalog no. R8875), antimycin (catalog no. A8674), and fluorocarbonyl cyanide phenylhydrazone (FCCP) (catalog no. C2920) were obtained from Millipore Sigma. The fluorescent dyes CellRox green (catalog no. C10444), MitoSox red (catalog no. M36008), calceinAM (catalog no. C1430), BODIPY 493/503 (4,4-difluoro-1,3,5,7,8-pentamethyl-4-bora-3a,4a-diaza-s-indacene) (catalog no. D3922) were obtained from Thermo Fisher Scientific. For immunostaining, we used rabbit polyclonal primary antibodies against gp91^phox (ab80508; Abcam), p40^phox (sc-18252-R; Santa Cruz Biotechnology), and LC3B, mouse monoclonal antibody against p62 (catalog no. IC8028G; R&D Systems), and secondary antibody Alexa Fluor 488 goat anti-rabbit IgG (H+L) (catalog no. A11034; Thermo Fisher Scientific).

Chandra P., He L., Zimmerman M., Yang G., Köster S., Ouimet M., Wang H., Moore K.J., Dartois V., Schilling J.D, & Philips J.A. (2020). Inhibition of Fatty Acid Oxidation Promotes Macrophage Control of Mycobacterium tuberculosis. mBio, 11(4), e01139-20.

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