Sorafenib, nilotinib, sunitinib, imatinib, gefitinib, lapatinib, dasatinib, PD-173074, selumetinib, crizotinib, tofacitinib and pazopanib were purchased from LC Laboratories (Woburn, Massachusetts, USA). Roswell Park Memorial Institute Medium (RPMI) and Geltrex basement membrane was purchased from Life Technologies (North Shore City, New Zealand). Met, P-Met (Y1234/Y1235), SRC, P-SRC (Y416), AKT, P-ATK (S473), cyclin D1, cleaved caspase 3, α-tubulin and EGFR antibodies were purchased from Cell Signaling Technology (Danvers, Massachusetts, USA). β-Tubulin was purchased from Sigma-Aldrich (Auckland, New Zealand).
Pd 173074
Manufactured by LC Laboratories
Sourced in United States
PD-173074 is a specific inhibitor of the fibroblast growth factor receptor (FGFR) tyrosine kinase. It is commonly used in research applications to study the role of FGFR signaling in various biological processes.
Automatically generated - may contain errors
Lab products found in correlation
α tubulin, by Cell Signaling Technology (1 mentions)
Geltrex basement membrane, by Thermo Fisher Scientific (1 mentions)
β tubulin, by Merck Group (1 mentions)
Cleaved caspase 3, by Cell Signaling Technology (1 mentions)
Gefitinib, by LC Laboratories (1 mentions)
Lapatinib, by LC Laboratories (1 mentions)
Tofacitinib, by LC Laboratories (1 mentions)
Dasatinib, by LC Laboratories (1 mentions)
Imatinib, by LC Laboratories (1 mentions)
Crizotinib, by LC Laboratories (1 mentions)
Sorafenib, by LC Laboratories (1 mentions)
Sunitinib, by LC Laboratories (1 mentions)
Pazopanib, by LC Laboratories (1 mentions)
Nilotinib, by LC Laboratories (1 mentions)
Selumetinib, by LC Laboratories (1 mentions)
2 protocols using pd 173074
1
Anticancer Drug Signaling Pathway Analysis
2
Investigating Chronic Kidney Disease Progression
Check if the same lab product or an alternative is used in the 5 most similar protocols
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CKD was induced by 1-step 5/6 nephrectomy. 5, 57 Duration of uremia was 8 weeks (renal artery and vein sampling were performed after 14 weeks of uremia). UUO was performed by ligation of the left ureter. UNX was performed by ligation of the renal vessel and removal of the kidney. 5 A group of rats had their parathyroid glands removed by excision under stereomicroscope. 9, 35, 58 Rats were anesthetized with fentanyl/fluanisone and midazolam for the surgical procedures and received carprofen as pain relief. Pentobarbital was used at killing. 5 The renal artery was punctured close to its junction with the aorta. The renal vein was punctured after prior ligation of the adrenal and testicular veins and clamping of the vena cava inferior. 10 The aorta was punctured 15 minutes after UNX or NX.
A single 200-ng dose of calcitriol (Leo Pharma, Ballerup, Denmark) was given i.p., and the kidney was harvested after 24 hours. 37 The impact of FGFR signaling was studied using a single 20-mg dose of the pan-FGFR inhibitor PD173074 (LC Laboratories, Woburn, MA) dissolved in 200 ml 96% ethanol administered by oral gavage.
A single 200-ng dose of calcitriol (Leo Pharma, Ballerup, Denmark) was given i.p., and the kidney was harvested after 24 hours. 37 The impact of FGFR signaling was studied using a single 20-mg dose of the pan-FGFR inhibitor PD173074 (LC Laboratories, Woburn, MA) dissolved in 200 ml 96% ethanol administered by oral gavage.
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