Ge revolution evo

All CCTAs were performed in a cranio-caudal direction during end-inspiration, with retrospective ECG-gating, on a 128-slice CT scanner (GE Revolution EVO, GE Medical Systems, Milwaukee, WI). The following parameters were applied: detector collimation width of 0.625 mm, gantry rotation time of 0.6 s, spiral pitch automatically adjusted on heart rate and ranging from 0.16 to 0.30, and matrix of 512 × 512 pixels. Tube voltage and tube current modulation were fixed according to patient’s body mass index (BMI): 80 kV and 150 mA for patients with BMI < 30, 100 kV and 200 mA for patients with BMI > 30.
A fixed amount (50 mL) of non-ionic high-iodine concentration contrast medium (400 mgI/mL iomeprol, Iomeron 400; Bracco Imaging, Italy) was intravenously injected at a fixed flow rate of 5 mL/s through an 18-gauge antecubital access, by using an automated triple-syringe power injector (MEDRAD® Centargo CT Injection System; Bayer AG, Berlin, Germany), followed by saline chaser bolus of 40 mL at the same flow rate. Scan delay was determined using a bolus-tracking software program (SmartPrep, GE Healthcare): CCTA acquisition started after automatic minimum diagnostic delay as soon as the trigger attenuation threshold (100 HU) was reached into a region-of-interest (ROI) placed in the ascending aorta at the level of pulmonary arteries.

Glucose metabolism was measured using [18 F]-fluorodeoxyglucose, collected on a Siemens Biograph Vision 600 PET/CT scanner (Siemens Medical Solution). Resting state scans were acquired at the same 4 time points using a standardized eyes closed protocol (10 mCi dose/scan, 30 minutes uptake period without arterial blood sampling, matrix size=440 × 440, and numbers of slice=88). A low-dose CT scan was performed for attenuation correction.
A high-resolution T1-weighted structural image was acquired on a 3 T GE SIGNA Architect (GE Healthcare) using the following sequence: axial slice orientation, slice thickness=1.2 mm, in-plane Resolution = 0.6 mm × 0.6 mm, matrix=256 × 256, TR = 8.432 ms, inversion time (TI) = 1100 ms, echo time (TE) = 3.188 ms, and flip angle=8°. Postsurgical high-resolution CT scan was also acquired on a GE Revolution EVO (GE Healthcare) with a resolution of 0.625 × 0.625 × 0.625 mm³ to localize the DBS leads.

All patients underwent a contrast-enhanced CT scan covering the cervical region, the chest, abdomen, and pelvis. Most of the scans were performed at the *institute* (n = 26) using one of the following multi-detector CT scanners: Discovery HD 750, GE Healthcare (n = 23) or GE Revolution Evo, GE Healthcare (n = 3). Four CT examinations were provided by small nearby centers (one from *city*, GE Revolution Evo; two from *city*, Siemens Definition 128; and one from *city*, Siemens Somatom Go All). Two CT scans were performed in private facilities in *city* (Siemens Power Scope 32).
A volume of 2 mL/kg of body weight of non-ionic contrast material (Xenetix 350; Iomeron 350) was injected into an antecubital vein. Chest images were obtained at an arterial phase 35 s after contrast material administration, and abdominal and pelvic images were obtained at a portal-venous phase (70 s).

All HRCT scans were acquired with the same CT scanner (GE Revolution Evo, General Electric Healthcare). Both lung and standard reconstructions were obtained. CT protocol was set as follows: 120 kV, 80 mA (automatic exposure control employed), rotation time of 0.7 s, pitch of 1 mm, and detector collimation of 0.7 mm. The scanning range was from the thorax inlet to the posterior costal angle, with patient keeping breath hold at full inspiration. Lung reconstruction settings were: window width 1600 HU, window level-600 HU, slice thickness 1.25 mm, slice interval 1.25 mm, matrix 512 × 512; adaptive statistical iterative reconstruction (ASIR-V) set to 30% was used. Standard reconstruction settings were: window width 400 HU, window level 40 HU, slice thickness 2.5 mm, slice interval 2.5 mm, matrix 512 × 512, ASIR-V set to 60%.