We analysed T1- and T2-weighted Fluid Attenuated Inversion Recovery (FLAIR) scans acquired across 7 MRI scanners. KLOSCAD and H70-study used Philips 3T Achieva scanners (Philips Medical Systems, The Netherlands) (19 (link), 23 (link)), and PATH used a Philips 1.5T Gyroscan scanner (22 (link)). Of the 474 MAS participants, 240 were scanned with a Philips 3T Intera Quasar scanner, and the remaining 234 with a Philips 3T Achieva Quasar Dual scanner (21 (link)). SLAS-I and SLAS-II used a Siemens 3T Tim Trio and a GE Healthcare 1.5T HDXT scanner, respectively. Detailed imaging acquisition parameters are summarised in Supplementary Table 1 .
3t achieva quasar dual scanner
Manufactured by Philips
Sourced in Netherlands
The Philips 3T Achieva Quasar Dual scanner is a magnetic resonance imaging (MRI) system designed for advanced clinical and research applications. It features a 3 Tesla superconducting magnet and dual-independent radio frequency (RF) transmission and reception channels, enabling high-quality imaging and spectroscopy.
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6 protocols using 3t achieva quasar dual scanner
1
Multimodal MRI Acquisition Across Scanners
2
Resting-state fMRI Acquisition Protocol
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All the fMRI data were acquired on a Philips 3T Achieva Quasar Dual scanner (Philips Medical Systems, Best, Netherlands) at Neuroscience Research Australia (NeuRA, Sydney, New South Wales, Australia. A T2-weighted echo-planar imaging (EPI) sequence was used, with the following parameters: repetition time/echo time = 2,000/30 ms, flip angle = 90°, field of view = 240 × 130.5 × 240 mm3, continuous axial slices = 29, slice thickness = 4.5 mm without interslice gap, matrix size = 128 × 128, resulting in voxel size = 1.9 × 1.9 × 4.5 mm3. The participants were instructed to hold still, keep their eyes closed and think of nothing during the 7-min resting-state fMRI scans. 208 volumes were required per subject.
3
Quantitative Cerebral Blood Flow Imaging using PCASL
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PCASL scans were acquired using a Philips 3T Achieva Quasar Dual scanner (Philips Medical Systems, Netherlands). The acquisition parameters were TR/TE = 4,500/12 ms, label duration = 1,800 ms, post label delay = 2,000 ms, flip angle = 90°, imaging matrix = 128 × 128, and FOV = 240 × 240 × 95 mm3. Sixteen slices with slice thickness of 5 mm and 1 mm gap between adjacent slices were acquired. Thirty control-tag pairs (i.e., 60 volumes) were scanned, with background suppression enabled. A separate M0 image without background suppression was also acquired with TR/TE = 6,000/12 ms and the same spatial resolution as the 30 control-tag pairs. T1-weighted scans were also acquired for the postprocessing. The scanning parameters were TR/TE = 6.5/3.0 ms, flip angle = 8°, FOV = 250 × 250 × 190 mm3, spatial resolution = 1 mm isotrophic, and matrix size = 256 × 256.
4
Resting-state fMRI Acquisition Protocol
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All MRI scans were obtained on a Philips 3T Achieva Quasar Dual scanner (Philips Medical Systems, Best, The Netherlands) located at the Neuroscience Research Australia, Sydney. For the resting-state scan, participants were required to ‘keep their eyes closed but not fall asleep and think of nothing in particular’. For each participant, we used a T2*-weighted echo planar imaging (EPI) sequence with the following parameters: repetition time/echo time = 2000/30 ms, flip angle = 90°, field of view (FOV) = 240 × 130.5 × 240 mm3, 29 continuous axial slices with slice thickness = 4.5 mm without interslice gap, matrix size = 128 × 128, yielding voxel size = 1.9 × 1.9 × 4.5 mm3. During about 7-min scan of fMRI, we acquired 208 volumes per participant. Acquisition parameters for T1-weighted structural MRI scans: TR = 6.39 ms, TE = 2.9 ms, flip angle = 8°, matrix size = 256 × 256, FOV = 256 × 256 × 190, and slice thickness = 1 mm with no gap in between, yielding 1 × 1 × 1 mm3 isotropic voxels.
5
Resting-state fMRI Acquisition Protocol
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Magnetic resonance imaging scans were conduct on a Philips 3T Achieva Quasar Dual scanner (Philips Medical Systems, Best, Netherlands), at NeuRA (Neuroscience Research Australia), Sydney. All participants were instructed to keep their eyes closed and think nothing when receiving resting-state fMRI scans. A T2∗-weighted echo planar imaging (EPI) sequence was used, with the following parameters: repetition time (TR)/echo time (TE) = 2000/30 ms, flip angle = 90°, field of view (FOV) = 240 × 130.5 × 240 mm3, 29 continuous axial slices, slice thickness = 4.5 mm without interslice gap, matrix size = 128 × 128, resulting in voxel size = 1.9 × 1.9 × 4.5 mm3. During the 7-min scan of fMRI, we required 208 volumes per subject. A 3D T1-weighted structural MRI was acquire d during the same scanning session with TR/TE = 6.39/2.9 ms, flip angle = 8°, FOV = 256 × 256 × 190 mm3, slice thickness = 1.0 without interslice gap, resulting an isotropic voxel size = 1 × 1 × 1 mm3.
6
Multimodal Brain Imaging Analysis
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Two hundred and forty of the 466 scans were acquired from a Philips 3 T Intera Quasar scanner (Philips Medical Systems, The Netherlands), whereas the remaining 226 participants were scanned on a Philips 3 T Achieva Quasar Dual scanner. A dummy variable indicating scanner has been used in all statistical analyses to account for any scanner differences. The two scanners were set to the same scanning parameters:
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