Skf 83822

Manufactured by Bio-Techne

Sourced in United Kingdom, Spain, Germany

SKF 83822 is a synthetic, nonsteroidal cannabinoid receptor agonist. It acts as a full agonist at both cannabinoid CB1 and CB2 receptors. SKF 83822 is commonly used in research applications involving the endocannabinoid system.

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Lab products found in correlation

4 protocols using skf 83822

D1/D5 Receptor Agonists in Auditory Memory

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The D1/D5 dopamine receptor-selective agonists SKF38393 (Sigma), SKF83822 (Tocris) and SKF83959 (Sigma), and the D1/D5 dopamine receptor-selective antagonist SCH23390 (Sigma) were dissolved in 0.9% saline and adjusted to ≈ pH 7. The doses used – that is, 0.06 μg/μL = 0.2 mM SKF38393 and 0.5 μg/μL = 1.25 mM SKF83959 for intracortical injections, and 5 mg/kg SKF38393, 0.625 mg/kg SKF83822, 2.5 mg/kg SKF83959, and 0.1 mg/kg SCH23390 for intraperitoneal injections – were based on our previous studies on mechanisms of FM discrimination memory in the gerbil auditory cortex [21 (link),22 (link)] in conjunction with studies on the pharmacological efficacy of the agonists [27 (link)].

Reichenbach N., Herrmann U., Kähne T., Schicknick H., Pielot R., Naumann M., Dieterich D.C., Gundelfinger E.D., Smalla K.H, & Tischmeyer W. (2015). Differential effects of dopamine signalling on long-term memory formation and consolidation in rodent brain. Proteome Science, 13, 13.

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Dopamine Receptor Agonists Protocol

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Cabergoline, metoclopramide, bromocriptine, propylnorapomorphine, quinpirole, pergolide and A68930 were purchased from Sigma-Aldrich. SKF 83822 and SKF 83566 were purchased from Tocris (Bristol, UK).

Matsuo K., Sone M., Honda-Kohmo K., Toyohara T., Sonoyama T., Taura D., Kojima K., Fukuda Y., Ohno Y., Inoue M., Ohta A., Osafune K., Nakao K, & Inagaki N. (2017). Significance of dopamine D1 receptor signalling for steroidogenic differentiation of human induced pluripotent stem cells. Scientific Reports, 7, 15120.

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Pharmacological Reagents for Neuromodulation

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Aripiprazole, clozapine, haloperidol hydrochloride, H89 dihydrochloride, L 741,626, MDL 100907, paliperidone, risperidone, SKF 83822, SCH 39166, TCB-2, WAY 100635, 7-OH-DPAT and 8-OH-DPAT were purchased from Tocris Bioscience (Spain). Forskolin and selumetinib (AZD6244) were purchased from Selleckchem (Spain). Cholera toxin (CTX), pertussis toxin (PTX) and 12-O-tetradecanoylphorbol-13-acetate (TPA) were purchased from Sigma-Aldrich (MO, USA). YM-254890 was purchased from Adipogen Life Sciences (CA, USA). All were dissolved in dimethyl sulfoxide, except CTX and WAY 100635 that were dissolved in water.

Ruso-Julve F., Pombero A., Pilar-Cuéllar F., García-Díaz N., Garcia-Lopez R., Juncal-Ruiz M., Castro E., Díaz Á., Vazquez-Bourgón J., García-Blanco A., Garro-Martinez E., Pisonero H., Estirado A., Ayesa-Arriola R., López-Giménez J., Mayor F J.r., Valdizán E., Meana J., Gonzalez-Maeso J., Martínez S., Vaqué J.P, & Crespo-Facorro B. (2019). Dopaminergic control of ADAMTS2 expression through cAMP/CREB and ERK: molecular effects of antipsychotics. Translational Psychiatry, 9, 306.

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Pharmacological Modulation of Cocaine Effects

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Cocaine hydrochloride (20 mg/ml/kg, Laboratorios Verardo y Cia., Argentina); the dopamine D1R antagonist SCH 23390 hydrochloride (1.5 μg/μl, Sigma-Aldrich, Germany); and GABAA receptor agonist muscimol (0.1 μg/μl, Sigma-Aldrich, Germany) were all dissolved in sterile 0.9% physiological saline. The dopamine D1R agonist SKF 38393 hydrochloride (12.5 μg/μl, Sigma-Aldrich, Germany); SKF 83822 (1 μg/μl, Tocris Bioscience, UK); and selective inhibitor of MEK U0126 (0.8 μg/μl, Sigma-Aldrich, Germany) were dissolved in sterile 0.9% physiological saline supplemented with DMSO (10% final concentration, Ernesto van Rossum y Cia., Buenos Aires, Argentina). The doses used were determined based on previous studies showing the effect of each compound on learning or behavioral performance [12, (link)13] .

Castillo Díaz F., Hernandez M.A., Capellá T, & Medina J.H. (2019). Dopamine Neurotransmission in the Ventral Tegmental Area Promotes Active Forgetting of Cocaine-Associated Memory. Molecular neurobiology, 56(9).

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