Ammonium format

Ammonium format and dimethyl sulfoxide (DMSO) were purchased from Sigma-Aldrich (Buchs, Switzerland). Gradient grade methanol, water, formic acid (FoA, 98–100%), isopropyl alcohol, and acetonitrile were products of Merck (Darmstadt, Germany). Human blank blood, stabilised by citrate-phosphate-derivative with adenine, was obtained from the local blood donation centre.
Ivermectin and ritonavir as well as the internal standard Ivermectin-d₂ were purchased from Toronto Research Chemicals (Toronto, Canada). Rifampicin, ketoconazole, and piperonyl butoxide were obtained from Sigma-Aldrich.

The following terpenoid standards were purchased from Supelco: α-pinene, camphene, β-pinene, myrcene, 3-carene, α-terpinene, p-cymene, limonene, γ-terpinene, fenchone, terpinolene, linalool, camphor, isoborneol, borneol, menthol, α-terpineol, β-citronellol, neryl acetate, geranyl acetate, α-cedrene, β-caryophyllene, α-humulene, cis-nerolidol, geranyl isobutyrate, caryophyllene oxide, β-eudesmol, α-bisabolol, and phytol. Cannabinoid standards were purchased from Sigma Aldrich (1 mg/mL): cannabidiolic acid (CBD-A), cannabigerolic acid (CBG-A), cannabigerol (CBG), cannabidiol (CBD), cannabinol (CBN), Δ-9-tetrahydrocannabinol (Δ-9-THC), Δ-8-tetrahydrocannabinol (Δ-8-THC), cannabichromene (CBC), Δ-9-tetrahydrocannabinolic acid (Δ-9-THC-A), and cannabichromenic acid (CBC-A). Acid standards were dissolved in acetonitrile, and nonacid standards were dissolved in methanol. Hexane, ammonium format, and acetonitrile were purchased from Sigma Aldrich, methanol was purchased from J. T. Baker and formic acid was purchased from Scharlau. Chemical structures of essential oils and cannabinoids are presented in Supplementary Materials [37 ,38 ,39 ].

LC–MS grade acetonitrile and gradient solvents including isopropanol, methanol, dichloromethane and ethyl acetate were provided by Thermo-Fisher (Thermo Fisher Scientific, USA). Formic acid 98%, ammonium hydroxide, ammonium format and ammonium acetate were purchased from Sigma-Aldrich (Sigma-Aldrich Co. Louis St., MO, USA).