Participants underwent a 60-minute dynamic scan with 11[C] Pittsburgh Compound B (PIB) [43 (link)]. PET imaging was performed with a Siemens 962 HR+ ECAT PET or Biograph 40 scanner (Siemens/CTI, Knoxville KY). Structural magnetic resonance imaging (MRI) using MPRAGE T1-weighted images was also acquired. Structural MRIs were processed using FreeSurfer [44 (link)] (http://freesurfer.net/ ) to derive cortical and subcortical regions of interest used in the PET processing [45 (link), 46 (link)]. Regional PIB values were converted to standardized uptake value ratios (SUVRs) using cerebellar grey as a reference and partial volume corrected using a regional spread function approach [45 (link), 46 (link)]. Values from the left and right lateral orbitofrontal, medial orbitofrontal, precuneus, rostral middle frontal, superior frontal, superior temporal, and middle temporal cortices were averaged together to represent a mean cortical SUVR. PIB positivity was defined as a mean cortical SUVR>1.42 [42 (link)], which is commensurate with a mean cortical binding potential of 0.18 that have previously been used to define PIB positivity [45 (link)].
962 hr ecat pet
Manufactured by Siemens
Sourced in Cayman Islands
The 962 HR+ ECAT PET is a positron emission tomography (PET) scanner developed by Siemens. It is designed to capture detailed images of the body's biochemical and physiological processes. The core function of this equipment is to provide high-resolution imaging for various medical applications.
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3 protocols using 962 hr ecat pet
1
PET Imaging of Amyloid Deposition
2
PiB PET Imaging for Amyloid-Beta Quantification
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Participants received a single intravenous bolus injection of 11[C] PiB (between 4.7 and 19.0 mCi). PET imaging [24 (link)] was conducted with a Siemens 962 HR+ ECAT PET or Biograph 40 scanner (Siemens/CTI, Knoxville KY), and magnetic resonance imaging (MRI) using MPRAGE T1-weighted images (1 mm×1 mm×1.25 mm) was obtained for anatomic reference as described previously [25, 26 (link)]. Participants underwent a 60-min dynamic scan with 11[C] PiB, and PET data was processed using regions of interest (ROIs) derived from structural MRIs using Freesurfer [25, 26 (link)]. Regional time-activity curves were extracted for each ROI, and binding potentials were calculated using Logan graphical analysis [27 (link)] with cerebellar gray matter as the reference region. The mean cortical binding potential (MCBP) was calculated based on a set of selected cortical regions known to have high levels of deposition in AD [28 (link)], including precuneus, rostral middle frontal cortex, superior frontal cortex, superior temporal cortex, middle temporal cortex, lateral orbitofrontal cortex, and medial orbitofrontal cortex [25 (link)]. A MCBP cutoff of >0.18 for positivity was chosen to be consistent with prior studies [9, 28–30 (link)].
3
PET Imaging of Amyloid Burden
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