Non-compartmental pharmacokinetic analysis was performed using WinNonlin Version 2.1 (Pharsight Corporation, Mountain View, CA, USA) software. The area under the mean plasma concentration-time curve extrapolated to infinity (AUC) was calculated using a linear-up and log-down method. Maximum concentration and the time when it was observed (Cmax and tmax, respectively) were reported as observed. Terminal half-life (t1/2) was calculated as t1/2 = ln2/λz, where λz is the slope of the terminal phase of the plasma concentration-time curve in the semi-log plot calculated by linear regression. Mean residence time (MRT) was calculated as AUC/AUMC, where AUMC is the area under the first moment curve. Relative bioavailability Fr of NADES versus suspension was estimated as a ratio of AUC following the administration of NADES and AUC following the administration of the suspension.
Winnonlin version 2
Manufactured by Pharsight
Sourced in United States
WinNonlin Version 2.1 is a software application used for the analysis and modeling of pharmacokinetic and pharmacodynamic data. It provides a comprehensive set of tools for the analysis and interpretation of data related to the behavior of drugs in the body.
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Lab products found in correlation
2 protocols using winnonlin version 2
1
Noncompartmental Pharmacokinetic Analysis
2
Theophylline Pharmacokinetic Analysis
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Individual plasma concentration-time profiles were analyzed by non-compartmental pharmacokinetic analysis using WinNonlin version 2.1 (Pharsight, Mountain View, CA, USA).
Maximum plasma concentration (C max ) and corresponding sampling time (t max ) were recorded as observed. Half-life of the terminal phase (t 1/2,z ) was calculated as the natural logarithm of 2 divided by the slope ( z ) of the linear regression line of the terminal log-linear portion of the concentrationtime curve. Area under the plasma concentration curve from time 0 to the last measured concentration at 24 h (AUC 24 ) was calculated by the linear trapezoidal rule and extrapolated to infinite time (AUC ∞ ) by addition of the term C(24)/ z , where C( 24) is theophylline plasma concentration at 24 h. Mean residence time (MRT) was calculated as AUMC/AUC, where AUMC is the area under the first moment curve.
Maximum plasma concentration (C max ) and corresponding sampling time (t max ) were recorded as observed. Half-life of the terminal phase (t 1/2,z ) was calculated as the natural logarithm of 2 divided by the slope ( z ) of the linear regression line of the terminal log-linear portion of the concentrationtime curve. Area under the plasma concentration curve from time 0 to the last measured concentration at 24 h (AUC 24 ) was calculated by the linear trapezoidal rule and extrapolated to infinite time (AUC ∞ ) by addition of the term C(24)/ z , where C( 24) is theophylline plasma concentration at 24 h. Mean residence time (MRT) was calculated as AUMC/AUC, where AUMC is the area under the first moment curve.
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