TRAIL was commercially supplied (SuperKiller, Enzo Life Sciences, Farmingdale, NY, USA) or produced from 293T cells as described30 (link). Caspase inhibitors (BD Pharmingen, San Diego, CA, USA) were: Z-VAD-FMK (general caspase inhibitor), Z-FA-FMK (negative control). Bcl-2, Bcl-xL inhibitors ABT-263 and WEHI-539 were purchased from Cayman Chemicals (Ann Arbor, MI, USA). FasL and N-acetyl-L-cysteine (NAC) were purchased from Sigma-Aldrich (MO, USA). NUTLIN-3a was purchased from MedChemExpress (NJ, USA). Doxycycline was purchased from Sigma-Aldrich (Cat. No: D9891). D-luciferin was purchased from Biotium (CA, USA). Chaetocin was purchased from two sources (C9492–1mg, Sigma-Aldrich, MO, USA) and (S8068, Selleckchem, Houston, TX, USA). The epigenetic tool library was constructed as described31 (link).
Wehi 539
Manufactured by Cayman Chemical
Sourced in United States
WEHI-539 is a small molecule that inhibits the activity of the B-cell lymphoma 2 (BCL-2) family of proteins. It is commonly used in scientific research to study the role of BCL-2 proteins in various biological processes.
Automatically generated - may contain errors
Lab products found in correlation
Doxycycline, by Merck Group (1 mentions)
N acetyl l cysteine, by Merck Group (1 mentions)
D luciferin, by Biotium (1 mentions)
Z vad fmk, by BD (1 mentions)
Chaetocin, by Merck Group (1 mentions)
Z fa fmk, by BD (1 mentions)
Nutlin 3a, by MedChemExpress (1 mentions)
Torin1, by Bio-Techne (1 mentions)
Cycloheximide (chx), by Merck Group (1 mentions)
Rapamycin, by Merck Group (1 mentions)
Actinomycin d, by Merck Group (1 mentions)
Abt 199, by Selleck Chemicals (1 mentions)
Q vd oph, by Cayman Chemical (1 mentions)
S63845, by Selleck Chemicals (1 mentions)
Abt 263, by Selleck Chemicals (1 mentions)
Azd2014, by Selleck Chemicals (1 mentions)
Rapalink 1, by MedChemExpress (1 mentions)
2 protocols using wehi 539
1
Apoptosis Induction and Inhibition Assays
2
Compound Evaluation Across Cell Models
Check if the same lab product or an alternative is used in the 5 most similar protocols
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The following compounds were used at the specified concentrations: ABT-263 (SelleckChem #S1001 for cell culture studies; MedChem Express #HY-10087 for mouse studies), S63845 (SelleckChem, #S8383), rapamycin (EMD Millipore, #553210 for cell culture studies; LC Laboratories, #R-500 for mouse studies), Torin1 (Tocris, #4247), AZD-2014 (SelleckChem, #S2783), Rapalink-1 (MedChem Express, # HY-111373), Q-VD-OPh (Cayman Chemicals, #15260), ABT-199 (SelleckChem. #S8048), WEHI-539 (Cayman Chemicals, #21478), cycloheximide (Sigma, #01810) and actinomycin D (Sigma, #A9415).
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