Cobas c analyzer

Manufactured by Roche

Sourced in United States

The Cobas c analyzer is a clinical chemistry analyzer produced by Roche Diagnostics. It is designed to perform a variety of routine and specialized laboratory tests, including the measurement of analytes in biological samples such as blood, serum, and urine. The Cobas c analyzer utilizes advanced technology and automation to provide accurate and reliable results.

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Lab products found in correlation

Cobas e602 analyzer, by Roche (1 mentions) Xn20 analyzer, by Sysmex (1 mentions) Elecsys ferritin, by Roche (1 mentions) Enzymatic colorimetric assay, by Roche (1 mentions) Monovettes, by Sarstedt (1 mentions) Cobas e801 analyzer, by Roche (1 mentions) Cobas c 513 analyzer, by Roche (1 mentions) P modular system, by Roche (1 mentions) Modular p800 system, by Roche (1 mentions) Modular analytics e170, by Roche (1 mentions)

8 protocols using cobas c analyzer

Comprehensive Liver and Kidney Panel

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Serum aspartate aminotransferase (AST), bilirubin, sodium, potassium, urea, creatinine, and plasma ammonia were measured using a cobas® c analyzer (Roche Diagnostics, Indianapolis, U.S.A.); international normalized ratio (INR) with an STA® prothrombin time assay kit (Diagnostica Stago SAS, Asnières sur Seine Cedex, France); serum lactate with an ABL 800 flex blood gas analyser (Radiometer Medical ApS, Brønshøj, Denmark); and Lysine-vasopressin with a (Lys⁸) vasopressin ELISA kit (Sigma–Aldrich, St. Louis, U.S.A.).

Hammond J.S., Godtliebsen F., Steigen S., Guha I.N., Wyatt J., Revhaug A., Lobo D.N, & Mortensen K.E. (2019). The effects of terlipressin and direct portacaval shunting on liver hemodynamics following 80% hepatectomy in the pig. Clinical Science (London, England : 1979), 133(1), 153-166.

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Serum Uric Acid Measurement Protocol

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Serum uric acid was measured at the outpatient screening to determine study eligibility, as well as at baseline, at the 4-week check-up visit, and at the 8-week follow-up visit. The measurements were performed using the Roche Cobas c analyzer with a colorimetric uricase method (Roche Diagnostics, Indianapolis, IN) with an intra-assay coefficient of variation (CV) of 0.6% and an inter-assay CV of 1.3%.

Borgi L., McMullan C., Wohlhueter A., Curhan G.C., Fisher N.D, & Forman J.P. (2016). Effect of Uric Acid Lowering Agents on Endothelial Function: A Randomized, Double-Blind, Placebo-Controlled Trial. Hypertension (Dallas, Tex. : 1979), 69(2), 243-248.

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Biomarker Analysis of Blood Samples

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Hemoglobin, ferritin, and CRP concentrations were determined by Medlab Central Medical Testing Laboratory (Palmerston North, New Zealand) using standard procedures. Hemoglobin concentration was determined in EDTA-treated blood using the sodium lauryl sulfate method on an automated Sysmex XN20 analyzer. Ferritin concentration was determined in serum samples using an electrochemiluminescence immunoassay (Elecsys^® Ferritin, Roche Diagnostics International Ltd) on a Roche Cobas e602 analyzer. CRP concentration was determined in serum samples using the immunoturbidometric method (Roche Diagnostics International Ltd) on a Cobas C analyzer.

Henare S.J., Nur Singh N., Ellis A.M., Moughan P.J., Thompson A.K, & Walczyk T. (2019). Iron bioavailability of a casein-based iron fortificant compared with that of ferrous sulfate in whole milk: a randomized trial with a crossover design in adult women. The American Journal of Clinical Nutrition, 110(6), 1362-1369.

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Plasma Lactate Quantification by Cobas

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Quantitative determination of lactate in plasma from retro-orbital bleeding was assessed by Cobas C Analyzer (Lactate Gen. 2 – Roche Diagnostics).

D’Alterio C., Buoncervello M., Ieranò C., Napolitano M., Portella L., Rea G., Barbieri A., Luciano A., Scognamiglio G., Tatangelo F., Anniciello A.M., Monaco M., Cavalcanti E., Maiolino P., Romagnoli G., Arra C., Botti G., Gabriele L, & Scala S. (2019). Targeting CXCR4 potentiates anti-PD-1 efficacy modifying the tumor microenvironment and inhibiting neoplastic PD-1. Journal of Experimental & Clinical Cancer Research : CR, 38, 432.

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Automated Lipid Quantification in Plasma

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TC and HDL-C were measured from heparin-coated Monovettes (Sarstedt Monovette orange). Analyses were performed using in vitro assays (enzymatic colorimetric assays, Roche, Mannheim, Germany) for the quantitative determination of blood lipids in human plasma on a Roche/Hitachi Cobas C Analyzer (Roche, Mannheim, Germany). The inter-and intra-assay CVs were ≤ 1.2% and ≤ 2.5%, respectively.

Auer A., Semmer N.K., von Känel R., Thomas L., Zuccarella-Hackl C., Wiest R, & Wirtz P.H. (2024). Taking appreciation to heart: appreciation at work and cardiovascular risk in male employees. Frontiers in Public Health, 12, 1284431.

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Biochemical Analyses in Clinical Care

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Glucose, TC, TAG, HDL-C, LDL-C, HbA₁c, and IL-6 were analyzed by routine hospital methods in the Laboratory of Analysis of the Complejo Hospitalario of Jaén. Particularly, glucose, TC, TAG, and HDL-C were measured by a spectrophotometric procedure using a Cobas c analyzer (Roche/Hitachi). LDL-C levels were estimated indirectly with the Friedewald equation. The percentage of HbA₁c was determined by a turbidimetric inhibition immunoassay (TINIA) of hemolyzed blood samples on a Cobas c-513 analyzer (Roche). IL-6 was quantified by an electrochemiluminescence immunoassay on a Cobas e-801 analyzer (Roche).

Naranjo Á., Álvarez-Soria M.J., Aranda-Villalobos P., Martínez-Rodríguez A.M., Martínez-Lara E, & Siles E. (2024). Hydroxytyrosol, a Promising Supplement in the Management of Human Stroke: An Exploratory Study. International Journal of Molecular Sciences, 25(9), 4799.

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Fasting Glucose and Lipid Profile

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Participants were requested to fast overnight before 3 mL of blood samples were collected from the median cubital vein. Serum blood glucose and lipid profile analysis were done using Roche/Hitachi Cobas C Analyzer (Roche Diagnostics GmbH, D-68298 Mannheim) with the protocol of GLUC3 for glucose, TRIGL for triglycerides, and HDLC3 for HDL analysis.

Utami N., Lestari L.A., Nurliyani N., & Harmayani E. (2021). Consumption of jelly dessert containing porang (Amorphophallus oncophyllus) glucomannan and inulin along with low-calorie diet contributes to glycemic control of obese adults: a randomized clinical trial. Food Research, 5(3), 152-162.

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Iron Deficiency Diagnosis Protocol

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Blood was drawn in the morning. Transferrin was measured using an immunoturbidimetric assay (Cobas c analyzer, Modular P system, Roche diagnostics, Mannheim, Germany). Serum ferritin concentrations were determined using the electrochemiluminescence immunoassay (Modular analytics E170, Roche diagnostics, Mannheim, Germany). Serum iron was measured using photometry (Modular P800 system; Roche diagnostics, Mannheim, Germany). Transferrin saturation [TSAT (%)] was calculated as 100 × serum iron (μmol/l)/25 × transferrin (g/l) 12. ID was defined as TSAT <20% and ferritin <300 μg/l. Anemia was defined as Hb<13 g/dl (M) or <12 g/dl (F).

Eisenga M.F., Minović I., Berger S.P., Kootstra-Ros J.E., van den Berg E., Riphagen I.J., Navis G., van der Meer P., Bakker S.J, & Gaillard C.A. (2016). Iron deficiency, anemia, and mortality in renal transplant recipients. Transplant international : official journal of the European Society for Organ Transplantation, 29(11).

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