Eudragit s100

Manufactured by Merck Group

Sourced in United States

Eudragit S100 is a coating material used in the pharmaceutical industry. It is a copolymer of methacrylic acid and methyl methacrylate. Eudragit S100 is designed to be resistant to gastric fluids and dissolve in the intestinal environment.

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Lab products found in correlation

4 protocols using eudragit s100

Fabrication of Polymeric Nanoparticles

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ELUX was purchased from Beijing Mesochem Technology Co., Ltd., China (PLGA)Poly(D,L-lactide-co-glycolide) (lactide:glycolide ratio of 75:25) were purchased from Lactel Absorbable Polymer (Pelham, AL, United States). Eudragit S100 and Poly(vinyl) alcohol were purchased from Sigma–Aldrich (St. Louis, MO, United States). All reagents/chemicals used in the experiment were analytical grade.

Anwer M.K., Al-Shdefat R., Ezzeldin E., Alshahrani S.M., Alshetaili A.S, & Iqbal M. (2017). Preparation, Evaluation and Bioavailability Studies of Eudragit Coated PLGA Nanoparticles for Sustained Release of Eluxadoline for the Treatment of Irritable Bowel Syndrome. Frontiers in Pharmacology, 8, 844.

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Chitosan-based Nanoparticle Encapsulation

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Chitosan (CH) (viscosity grade 200–400 mPas, MW = 190–310 kDa), tripolyphosphate (TPP), Eudragit^® S100 (an enteric polymer), and FITC were procured from Sigma-Aldrich, St. Louis, MO, USA. Dialysis semipermeable membrane (MWCO, 10–12 KDa) and trehalose dihydrate were bought from HiMedia, Mumbai, India. All other excipients, as well as solvents utilized in the experiment, were of analytical grade.

Sreeharsha N., Rajpoot K., Tekade M., Kalyane D., Nair A.B., Venugopala K.N, & Tekade R.K. (2020). Development of Metronidazole Loaded Chitosan Nanoparticles Using QbD Approach—A Novel and Potential Antibacterial Formulation. Pharmaceutics, 12(10), 920.

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Celecoxib-loaded Nanoparticles for Colon Cancer

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Celecoxib was supplied from SEDICO Pharmaceutical Company (Cairo, Egypt). Polyethyleneimine, Span 80, Eudragit S100, sodium carboxymethyl cellulose (MW: 90000 Da), 1,2-dimethylhydrazine, methanol (HPLC grade), Tween 80, and chloroform (HPLC grade) were purchased from Sigma-Aldrich (St. Louis, MO). Dialysis membrane (MW cut off: 12000 Da) was purchased from SERVA Electrophoresis GmbH (Heidelberg, Germany). Enzyme-linked immunosorbent assay (ELISA) kits for cyclooxygenase-2 (Catalog no. MBS266603) and Wnt-2 (Catalog no. MBS7700340) were procured from MyBioSource (San Diego, CA, USA) while that for β-catenin (Catalog number K3383–100) was obtained from BioVision (Waltham, MA, USA). Monoclonal antibody for CXCR-4 (Catalog no. PA1–21626) for immunohistochemistry assay and primers for TCF3 (Catalog no. PA5–20900) and LEF1 (Catalog no. PA5102851) for qRT-PCR were purchased from ThermoFisher (Inchinnan Business Park, Paisley, UK). Other ingredients and solvents utilized were of analytical grade.

El Menshawe S.F., Shalaby K., Elkomy M.H., Aboud H.M., Ahmed Y.M., Abdelmeged A.A., Elkarmalawy M., Abou Alazayem M.A, & El Sisi A.M. (2023). Repurposing celecoxib for colorectal cancer targeting via pH-triggered ultra-elastic nanovesicles: Pronounced efficacy through up-regulation of Wnt/β-catenin pathway in DMH-induced tumorigenesis. International Journal of Pharmaceutics: X, 7, 100225.

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Controlled-Release Mesalamine Formulation

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All chemicals were purchased in the analytical grades. Mesalamine, curcumin, SALG, chitosan, hydroxypropyl-β-cyclodextrin (HP-β-CD), and Eudragit^® S-100 were obtained from Sigma-Aldrich (St. Louis, MO, USA). Tri-ethyl citrate (TEC), liquid paraffin, span-80, acetic acid (99%), and sodium hydroxide were purchased from Sigma-Aldrich. Acetone, n-hexane, HCl, Mg-stearate, potassium dihydrogen phosphate, di-sodium-hydrogen-phosphate, methanol, and ethyl alcohol (99%) were procured from El-Nasr Pharmaceutical Co. for Chemicals (Cairo, Egypt). Anhydrous calcium chloride (Fine GRG 90%) was supplied by Fisher Scientific (Fairlawn, NJ, USA).

Heikal E.J., Kaoud R.M., Gad S., Mokhtar H.I., Alattar A., Alshaman R., Zaitone S.A., Moustafa Y.M, & Hammady T.M. (2023). Development of Novel pH-Sensitive Eudragit Coated Beads Containing Curcumin-Mesalamine Combination for Colon-Specific Drug Delivery. Gels, 9(4), 264.

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