Ca 7000 system

Manufactured by Sysmex

Sourced in Japan

The Sysmex CA 7000 system is a fully automated coagulation analyzer designed for clinical laboratory settings. It is capable of performing a wide range of coagulation and hemostasis tests, providing accurate and reliable results. The core function of the Sysmex CA 7000 system is to analyze coagulation parameters in patient samples.

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Lab products found in correlation

7600 clinical analyzer, by Hitachi (3 mentions) Lightcycler 480, by Roche (1 mentions) Modular evo, by Roche (1 mentions) Xe 2100 autoanalyzer, by Sysmex (1 mentions) Elecsys 2010, by Roche (1 mentions) Dimension rxl max, by Siemens (1 mentions) 5431 autoanalyzer, by Olympus (1 mentions) Xe 5000, by Sysmex (1 mentions) 7600 020 automatic biochemical analyzer, by Hitachi (1 mentions) Automatic analyzer 7600, by Hitachi (1 mentions) Cobas e602, by Roche (1 mentions) Xn 9000, by Sysmex (1 mentions)

Close spelling variants of this product

CA‐7000 System Coagulation Analyzer CA-7000

13 protocols using ca 7000 system

Automated Coagulation Assay Protocol

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Assays were performed for each sample using an automatic coagulative instrument (Sysmex CA-7000 System) according to the instructions provided by the biological reagent provider (Siemens Healthcare Diagnostics Products Gmbh).
Fresh whole blood (50 ml), collected in sodium citrate coagulation test tubes, was donated by the first author of this paper, which was approved by the ethics committee of Puai Hospital. After centrifugation (3000 rpm, 8 min), the supernatants (270 μL) were divided into containers. Compounds 1–8 were diluted for use with normal saline (with 1% DMSO) at 1 mg/ml. Then, all of the isolates (30 μL) were added into the plasma sequentially. After incubation in a 37 °C thermostatic water bath for 10 minutes, all of the samples were analysed with the automatic coagulative instrument, which had been supplied with activated partial Thromborel S, Throbin, Dade Actin Activated Cephaloplastin Reagent (Siemens Healthcare Diagnostics Products Gmbh) and calcium-chloride solutions. All of the tests were performed in an automated environment.

Lei L., Xue Y.B., Liu Z., Peng S.S., He Y., Zhang Y., Fang R., Wang J.P., Luo Z.W., Yao G.M., Zhang J.W., Zhang G., Song H.P, & Zhang Y.H. (2015). Coumarin derivatives from Ainsliaea fragrans and their anticoagulant activity. Scientific Reports, 5, 13544.

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Retrospective Analysis of Hepatic Biomarkers

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The laboratory data of all patients were reviewed retrospectively and included 1) biochemical tests reflecting hepatocytic damage: serum alanine transaminase (ALT), aspartate transaminase (AST), albumin (ALB), and total bilirubin, all assayed by colorimetric method (MODULAR EVO; Hoffmann-La Roche Ltd, Basel, Switzerland); 2) international standardized ratio for prothrombin time, determined according to the manufacturer’s instructions (CA-7000 System; Sysmex, Kobe, Japan); 3) HBV markers: HBV antigens (HBeAg) and antibodies (HBeAb), detected by commercially available enzyme immunoassays (Alisei Quality System; RADIM, Rome, Italy); and 4) HBV DNA, determined by fluorescent quantifying polymerase chain reaction with a low detection limit of 10³ copies/mL (LightCycler 480; Hoffmann-La Roche Ltd).

Liang L.B., Chen L.L., Chen E.Q., Liao J, & Tang H. (2015). Genotypic resistance profiles in Chinese patients with chronic hepatitis B virus infection and the efficacy of nucleoside analog rescue therapy. Therapeutics and Clinical Risk Management, 11, 417-423.

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Liver Disease Severity Evaluation

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For each patient, demographic information and laboratory data were collected on admission. Laboratory parameters, including alanine aminotransferase, aspartate aminotransferase, total protein, albumin, creatinine, total bilirubin, INR, platelet count, hemoglobin, and blood urea nitrogen, were collected. Biochemical analyses were conducted using a Hitachi 7600 Clinical Analyzer (Hitachi, Tokyo, Japan), Sysmex CA-7000 System (Sysmex, Kobe, Japan), and Sysmex XE-2100 Auto-Analyzer (Sysmex, Kobe, Japan) using standard methods. PTAR was calculated as INR divided by albumin (g/dL). Hepatic disease severity was evaluated by the Model for End-Stage Liver Disease (MELD) score as previously described [8 (link)].

Cai M., Han Z., He X, & Zhang J. (2021). Usefulness of International Normalized Ratio to Albumin Ratio for Evaluation of Mortality in Hepatitis B Virus-Associated Decompensated Cirrhosis. BioMed Research International, 2021, 6664574.

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Cardiac Biomarker Measurement Protocols

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D-dimer, TnI, N-terminal pro-B-type natriuretic peptide (NT-proBNP), C-reactive protein (CRP) were measured as cardiac biomarkers. D-dimer was measured with immunoturbidimetric assay using CA-7000 system (Sysmex, Kobe, Japan), and the reference value is < 0.5 mg/L. TnI was measured using electrochemiluminescence sandwich immunoassay method using Dimension RxL-Max (Siemens), and the reference value is < 0.05 ng/mL. NT-proBNP was measured using an electrochemiluminescence sandwich immunoassay method for NT-proBNP with an Elecsys 2010 analyzer (Roche Diagnostics, Mannheim, Germany). The analytic range of the NT-proBNP assay extends from 5 to 35,000 pg/mL. The reference value varies according to age and gender, and < 88 pg/mL for men and < 153 pg/mL for women in our institution. High-sensitivity C-reactive protein (hsCRP) was measured by the immunoturbidimetric CRP-Latex (II) assay using an Olympus 5431 autoanalyzer (Olympus America Inc., Center Valley, PA, USA) with reference range of < 0.5 mg/dL.

Kim J.Y., Kim K.H., Cho J.Y., Sim D.S., Yoon H.J., Yoon N.S., Hong Y.J., Park H.W., Kim J.H., Ahn Y., Jeong M.H., Cho J.G, & Park J.C. (2019). D-dimer/troponin ratio in the differential diagnosis of acute pulmonary embolism from non-ST elevation myocardial infarction. The Korean Journal of Internal Medicine, 34(6), 1263-1271.

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Comprehensive Blood Analysis Protocol

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A peripheral venous blood sample (6 mL) was collected from each
patient within the first 24 hours after admission to the ER. Blood
samples were used to analyze the hematological index and biochemical values.
Laboratory parameters measured included: white blood cells (WBC), platelets,
hemoglobin, red blood cell distribution width (RDW), neutrophil-lymphocyte
ratio (NLR), prothrombin time, total protein, albumin, alanine aminotransferase
(ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), creatine
kinase (CK), creatinine, potassium, pH, PaCO₂, and PaO₂.
All biochemical analyses were conducted using a Hitachi 7600 Clinical Analyzer
(Hitachi, Tokyo, Japan), Sysmex CA-7000 System (Sysmex, Kobe, Japan), and
Sysmex XE-2100 Automated Analyzer (Sysmex) using standard methods.

Zhang J., Zhao Y., Bai Y., Lv G., Wu J, & Chen Y. (2015). The significance of serum uric acid level in humans with acute paraquat poisoning. Scientific Reports, 5, 9168.

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Plasma D-dimer and Serum NSE Assays

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Fasting blood was collected from an antecubital vein into vacutainer tubes containing anticoagulant citrate buffer (1:9, buffer:blood; 3 mL of blood) and clotting agent (3.5 mL of blood), respectively, within 1 week prior to chemotherapy or radiotherapy. Plasma (for D-dimer assay) was obtained by centrifugation at 400 × g for 25 minutes. D-dimer levels were determined by immunoturbidimetric assay (Siemens Healthcare Diagnostics Products GmbH, Marburg, Germany) using a SYSMEX CA-7000 system (Sysmex Corp., Kobe, Japan). The cut-off value for plasma D-dimer levels used by the hospital laboratory was 0.55 mg/L fibrinogen equivalent units (FEU), based on the manufacturer’s recommendations. Serum (for neuron-specific enolase [NSE] assay) was obtained by centrifugation at 2860 × g for 15 minutes. Serum NSE levels were measured within 7 days before chemotherapy using a solid-phase radioimmunoassay method (SRL Inc., Tokyo, Japan). The cut-off value for plasma NSE levels was 16.3 ng/mL, based on the manufacturer’s recommendations.

Fan S., Zhao G, & An G. (2018). High pretreatment plasma D-dimer levels are associated with shorter overall survival in patients with small cell lung cancer. The Journal of International Medical Research, 47(1), 215-224.

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Serum HMGB1 Levels in ER Patients

Cited 1 time

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Each patient provided a peripheral venous blood sample (5 mL) during the first 24 hours after admission to the ER. Sera were isolated, frozen, and stored at −80 °C until use. Serum HMGB1 levels were measured using an enzyme-linked immunosorbent assay kit according to the manufacturer’s instructions (Yanhui Biotech, Shanghai, China).
Baseline hematological and laboratory parameters, including white blood cell (WBC), neutrophil, lymphocyte, and platelet counts, hemoglobin, prothrombin time, total bilirubin, albumin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, serum amylase, troponin I (cTnI), pH, partial pressure of carbon dioxide (PaCO2), and partial pressure of oxygen (PaO2) were measured using a Hitachi 7600 Clinical Analyzer (Hitachi, Tokyo, Japan), Sysmex CA-7000 System (Sysmex, Kobe, Japan), and Sysmex XE-5000 (Sysmex)^{8 (link)}, according to standard protocols.

Chen F., Liu Z., Li W., Li D, & Yan B. (2019). The significance of serum HMGB1 level in humans with acute paraquat poisoning. Scientific Reports, 9, 7448.

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Pretreatment Plasma D-dimer and Albumin Levels in ESCC

Cited 2 times

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As a part of clinical routine examinations, pretreatment plasma D-dimer levels, serum albumin levels, and CRP levels were measured 24 h to 1 week before surgery. Plasma D-dimer values were analyzed by a latex-enhanced immunoturbidimetric assay and a Sysmex CA 7000 system (Sysmex Corporation, Japan) according to the manufacturer’s instructions. Serum albumin levels and CRP levels were measured by using a Hitachi 7600-020 automatic biochemical analyzer (Hitachi, Japan). The optimal cutoff values of D-dimer and albumin in our study were verified using Youden’s index (YI) from the receiver operating characteristic (ROC) curve for ESCC prediction. The survival status was inserted into the YI to define the cutoff value as described by Huang et al. [22 (link)] and Liu et al. [23 (link)]. A high level of preoperative plasma D-dimer was defined as ≥0.5 μg/mL, and a low level of preoperative serum albumin was defined as <43.8 g/L.

Liu D.Q., Li F.F, & Jia W.H. (2016). Cumulative scores based on plasma D-dimer and serum albumin levels predict survival in esophageal squamous cell carcinoma patients treated with transthoracic esophagectomy. Chinese Journal of Cancer, 35, 11.

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Multicenter Coagulation Assay Validation

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The study was carried out in two laboratories, including the First Affiliated Hospital of Zhejiang University (Center 1) and The First People's Hospital of Hangzhou (Center 2). Both Centers, 1 and 2, used the same blood collection system (Becton Dickinson, Franklin Lakes, USA), Sysmex CA7000 system (Sysmex, Kobe, Japan), Siemens reagents (Siemens, Marburg, Germany), and International Sensitivity Index (ISI, ISI = 0.99).

Feng L., Zhao Y., Zhao H, & Shao Z. (2014). Effects of storage time and temperature on coagulation tests and factors in fresh plasma. Scientific Reports, 4, 3868.

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Comprehensive Biomarker Assessment in Hospitalized Patients

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When the patients were admitted to hospital, venous blood was collected into the procoagulant tube and the EDTA-K2 anticoagulant tube. Serum was separated from the procoagulant tube and stored in the refrigerator at − 80 °C. A Siemens Advia 2400 automatic biochemical analyser (Siemens, Erlangen, Germany) and its supporting reagents were used to determine Lp(a), ApoB, ApoA-Ι, total cholesterol (TC), triglycerides (TG), TP (total protein), ALB (albumin), urea, Cr (creatinine), UA (uric acid), eGFR, Glu (glucose), HDL-C, LDL-C, sdLDL and hs-CRP (high-sensitivity C-reactive protein). Among them, a microparticle-enhanced transmission immunoassay was used to detect the concentration of Lp(a), and a polyethylene glycol (PEG)-enhanced immunoturbidimetric assay was used to determine the level of ApoA-Ι and ApoB. A SysmexCA-7000 system (Sysmex, Kobe, Japan) was used to detect the red blood cell (RBC) count, haematocrit (HCT) as well as haemoglobin (Hb) concentration. We used the CKD-EPI 2009SCr equation to calculate eGFR.

Tao J., Dai W., Ye C., Yao Q., Zhou M, & Li Y. (2021). Preprocedural Lp(a) level and ApoB/ApoA-Ι ratio and the risk for contrast-induced acute kidney injury in patients undergoing emergency PCI. Lipids in Health and Disease, 20, 130.

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