Dutasteride

Stearic and oleic acid were purchased from Tokyo Chemical Industry (Oxford, UK). Dutasteride (purity > 98.0%) was obtained from Carbosynth (Compton, UK). Ethanol (96% v/v analytical grade) and Sephadex G-50 was obtained from Sigma-Aldrich (Dorset, UK). Phosal^® 53 MCT and Lutrol^® micro 68 were supplied by Lipoid GmbH (Ludwigshafen, Germany) and BASF Group (Ludwigshafen, Germany), respectively. Water (HPLC grade) was purchased from Fisher Scientific (Loughborough, UK). Deionised water was prepared in-house (PURELAB, ELGA, London, UK).

Lauric acid and stearic acid were purchased from Tokyo Chemical Industry (UK). Chitosan oligomer (CSO; MW < 3000 Da) and dutasteride (purity >98.0%) were obtained from Carbosynth (Newbury, UK). Ethanol (96% v/v analytical grade), acetic acid-d₄ (99.9 atom %D)_, 1-ethyl-3-(3-dimethylaminopropyl), carbodiimide hydrochloride (EDC.HCl), and Sephadex G-50 were obtained from Sigma-Aldrich (Dorset, UK). Acetic acid glacial (analytical reagent), water (HPLC grade), and acetone were purchased from Fisher Scientific (Loughborough, UK). Deuterium oxide (99.9 atom %D) was purchased from Cambridge Isotope Lab. Inc. (Tewksbury, MA, USA). Phosal^® 53 MCT and Lutrol^® micro 68 were gifted by Lipoid GmbH (Ludwigshafen, Germany) and the BASF Group (Ludwigshafen, Germany), respectively. Deionised water was produced in-house (PURELAB, ELGA, High Wycombe, UK).