Cobas c701

Manufactured by Roche

Sourced in Switzerland, Germany, China, France, Japan

The Cobas c701 is a clinical chemistry analyzer designed for use in medical laboratories. It is capable of performing a wide range of diagnostic tests on patient samples to assist in the diagnosis and monitoring of various medical conditions. The Cobas c701 is engineered to deliver accurate and reliable results, supporting healthcare professionals in making informed decisions about patient care.

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Lab products found in correlation

Cobas e602, by Roche (3 mentions) Cobas 8000 e602, by Roche (2 mentions) Gm 1000, by Seca (2 mentions) Arkray4030, by Sysmex (2 mentions) Xe 2100, by Sysmex (2 mentions) Uf 1000i, by Sysmex (2 mentions) Ids isys, by Immunodiagnostic Systems (2 mentions) Auto ga immulite 2000, by Siemens (2 mentions) Cobas e601, by Roche (2 mentions) Au2700, by Olympus (2 mentions) Cobas c701 702, by Roche (2 mentions) Cobas e801, by Roche (2 mentions) Solid phase sandwich enzyme linked immunosorbent assay kit, by Cusabio (2 mentions) Hba1c, by Bio-Rad (2 mentions) Cobas c501, by Roche (2 mentions) Cobas c702, by Roche (2 mentions) Elisa kit, by EUROIMMUN (1 mentions) Enzymatic colorimetric assay kit, by Roche (1 mentions) Model hem 752 fuzzy, by Omron (1 mentions) Quantikine, by R&D Systems (1 mentions)

63 protocols using cobas c701

Rituximab for Idiopathic Membranous Nephropathy

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Patients’ clinical and laboratory parameters were collected before RTX administration, and were repeated on every visit in month 3 and 6 after RTX administration. A follow-up period greater than 6 months was required for all patients. Follow up ended when patients received other immunosuppressive agents or received dialysis.
Prior to RTX administration, general clinical parameters including gender, age, blood pressure, previous treatment regimens, and current combination therapies were collected. At subsequent 3 months intervals after RTX administration, laboratory variables related with nephrotic syndrome and renal function were collected.
Anti-PLA2R antibodies were detected using a commercial enzyme-linked immunosorbent assay (ELISA) kit (EUROIMMUN AG, Lübeck, Germany). Blood urea nitrogen (BUN), and serum albumin were measured by colorimetry using Cobas c 701 (Roche, Basel, Switzerland). Serum creatinine was measured by Enzymatic methods using Cobas c 701 (Roche, Basel, Switzerland). The amount of proteinuria was evaluated by 24-h urine protein. The estimated glomerular filtration rate (eGFR) was calculated using the Chronic Kidney disease Epidemiology Collaboration (CKD-EPI) formula.

Guo Y., Wang L., Wang Y., Li X., Zhai Z., Yu L., Liang Y., Liu P, & Tang L. (2022). Rituximab in patients with membranous nephropathy and kidney insufficiency. Frontiers in Pharmacology, 13, 1002117.

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Standardized Calcium Measurement Protocol

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Blood samples were collected and centrifuged at 2000 g for 10 min at 4°C within 1 h after venipuncture. All biochemical measurements of calcium were performed in the same laboratory (Laboratory of Clinical Biochemistry, University Hospital of Nantes) using a photometric CalciumGen.2 assay on the basis of photometric measurements of the calcium–NM-BAPTA complex on Cobasc701 (Roche Diagnostics) according to the manufacturer’s instructions. All other biochemical parameters such as total 25 OH vitamin D on LIAISONXL (DiaSorin), total protein and magnesium on Cobasc701(Roche Diagnostics) and intact parathyroid hormone (PTH) on Cobase602 (Roche Diagnostics) were measured according to the manufacturer’s instructions. Protein-corrected calcium (pcCa) levels were estimated as follows: corrected calcium (mmol/L) = measured calcium (mmol/L)/(0.55 + total protein (g/L)/160) as described previously (19 (link)).

Duval M., Bach-Ngohou K., Masson D., Guimard C., Le Conte P, & Trewick D. (2018). Is severe hypocalcemia immediately life threatening?. Endocrine Connections, 7(10), 1067-1074.

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Serum Lipid and Liver Enzyme Profiling

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Blood samples were collected from each individual after overnight fasting. After centrifugation at 3500 rpm for 8 min, sera were collected and stored at 80 °C for follow-up experiments. Serum levels of alanine aminotransferase (ALT, IFCC method), aspartate transaminase (AST, colorimetry), total cholesterol (Chol, enzymatic colorimetry), triglycerides (TG, colorimetry), total bilirubin (TBI, Diazo method) and direct bilirubin (DBI, Diazo method) were assessed using Roche Cobas c 701 (Roche, Switzerland). The levels of apolipoprotein A1 (ApoA1) and apolipoprotein B (ApoB) were examined using immunoturbidimetric method, and the serum levels of high-density lipoproteins cholesterol (HDL-C), low-density lipoproteins cholesterol (LDL-C) were detected using surfactant clearance method, and lipoprotein a (Lpa) was examined using latex immunoturbidimetry method in Roche Cobas c 701 (Roche, Switzerland).

Cui Y., Cui X.D., Xu M., Fang M, & Cai M.J. (2019). Serum apolipoprotein C3 levels are negatively associated with hepatitis B virus DNA in HBeAg-negative chronic hepatitis B patients. Lipids in Health and Disease, 18, 138.

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Comprehensive Anthropometric and Biomarker Assessment

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Anthropometric measurements, including height, weight and body mass index (BMI), were obtained from an automatic electronic meter (SECA GM-1000, Seoul, Korea). Blood tests were processed by a hematology automated analyzer (SYSMEX XE-2100, Kobe, Japan). Urine tests were determined using an automated urine chemistry analyzer (ARKRAY4030, Tokyo, Japan) and a urinary tract infection analyzer (SYSMEX UF-1000i, Kobe, Japan). Biochemical detection was performed by an automatic modular analyzer (Cobas C701, Basel, Switzerland). Tumor markers such as alpha fetoprotein (AFP) and carcinoembryonic antigen (CEA) were measured by an immunology modular analyzer (Cobas 8000 e602, Basel, Switzerland).

Wu Z., Jiang Z., Li T., Xie C., Zhao L., Yang J., Ouyang S., Liu Y., Li T, & Xie Z. (2021). Structural variants in the Chinese population and their impact on phenotypes, diseases and population adaptation. Nature Communications, 12, 6501.

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Anthropometric and Biomarker Measurements

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Anthropometric measurements, including height, weight and body mass index (BMI), were obtained from an automatic electronic meter (SECA GM-1000, Seoul, Korea). Blood tests were processed by a hematology automated analyzer (SYSMEX XE-2100, Kobe, Japan). Urine tests were determined using an automated urine chemistry analyzer (ARKRAY4030, Tokyo, Japan) and a urinary tract infection analyzer (SYSMEX UF-1000i, Kobe, Japan). Biochemical detection was performed by an automatic modular analyzer (Cobas C701, Basel, Switzerland).
Tumor markers such as alpha fetoprotein (AFP) and carcinoembryonic antigen (CEA) were measured by an immunology modular analyzer (Cobas 8000 e602, Basel, Switzerland).

Wu Z., Jiang Z., Li T., Xie C., Zhao L., Yang J., Ouyang S., Liu Y., Li T., & Xie Z. (2021). Structural variants in Chinese population and their impact on phenotypes, diseases and population adaptation.

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Lipid Profile Determination in Plasma

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Blood samples were centrifuged at 1,000 rpm for 10 min and the serum was separated. 200 µL plasma samples were collected for lipid analysis, including low-density lipoprotein cholesterol (LDL-c), triglycerides (TG), high-density lipoprotein cholesterol (HDL-c), and total cholesterol (TC), using an automated biochemical analysis machine (Cobas c701, Roche) with an enzymatic colorimetric assay kit (Roche). All methods were operated based on the instructions of the assay kit.

Xie Z., Cheng Y., Zhang Q., Hao H., Yin Y., Zang L., Wang X, & Mu Y. (2021). Anti-obesity effect and mechanism of mesenchymal stem cells influence on obese mice. Open Life Sciences, 16(1), 653-666.

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Automated Measurements of Cardiovascular Risk

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BP measurements were obtained using an automated electronic device (Omron Model HEM-752 Fuzzy; Omron, Tokyo, Japan). HDL cholesterol, LDL cholesterol, and triglycerides were measured at the central laboratory using enzymatic methods with an autoanalyzer (cobas c 701; Roche, Mannheim, Germany).

Li M., Li J., Xu Y., Gao J., Cao Q., Ding Y., Xin Z., Lu M., Li X., Song H., Shen J., Hou T., He R., Li L., Zhao Z., Xu M., Lu J., Wang T., Wang S., Lin H., Zheng R., Zheng J., Baker C.J., Lai S., Johnson N.A., Ning G., Twigg S.M., Wang W., Liu Y, & Bi Y. (2024). Effect of 5:2 Regimens: Energy-Restricted Diet or Low-Volume High-Intensity Interval Training Combined With Resistance Exercise on Glycemic Control and Cardiometabolic Health in Adults With Overweight/Obesity and Type 2 Diabetes: A Three-Arm Randomized Controlled Trial. Diabetes Care, 47(6), 1074-1083.

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Biochemical Markers in Rat Sera

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The levels of ALT, AST, and Alb in rat sera were determined using an automatic biochemical analyzer (Cobas C701; Roche Biotechnology, Basel, Switzerland). The serum levels of HA, LN, PC, and IV-C were detected by radioimmunoassay using the corresponding kits.

Li D., Li W., Chen Y., Liu L., Ma D., Wang H., Zhang L., Zhao S, & Peng Q. (2018). Anti-fibrotic role and mechanism of Periplaneta americana extracts in CCl4-induced hepatic fibrosis in rats. Acta Biochimica et Biophysica Sinica, 50(5), 491-498.

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Biomarker Quantification from Fasted Samples

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Blood samples were collected between 08:00 and 10:00 h following an overnight fast. Samples were allowed to clot at room temperature for 30 min, centrifuged at 1008 g for 10 min and stored at −80°C until analysis. Calcium, albumin, PTH, glucose, insulin, 25-hydroxyvitamin D (25OHD), collagen type 1 C-telopeptide (CTX) and type I procollagen N-terminal peptide (PINP) were measured with autoanalysers (Cobas c701, c702, e411 and e602, Roche Diagnostics). The inter-assay precision was <6.0% for all tests. Insulin-like growth factor (IGF1) was measured by automated CLIA (IDS-iSYS, Immunodiagnostic Systems, Boldon, UK; inter-assay CV all <6.0%). Leptin and adiponectin were measured with manual ELISA (Quantikine, R&D Systems; inter-assay CV 3.8% for leptin and 2.8% for adiponectin). Sclerostin and periostin were measured by manual ELISA (Biomedica, Vienna, Austria) with inter-assay CV 9.1% and 6.0%, respectively.

Vilaca T., Evans A., Gossiel F., Paggiosi M., Eastell R, & Walsh J.S. (2022). Fat, adipokines, bone structure and bone regulatory factors associations in obesity. European Journal of Endocrinology, 187(6), 743-750.

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Glucose and Insulin Measurement Validation

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At T 0 , FG was assessed either with capillary blood from finger prick or with venous blood from venipuncture using a point-of-care analyser (Cholestech LDX, Cholestech Corp.) which reports plasma equivalent glucose concentrations/venous plasma glucose concentrations. In T 3 , an enzymatic UV test (Cobas c701, Roche Diagnostics GmbH) was used for FG analysis from NaF plasma. At T 0 , serum insulin concentrations were measured by luminescence immunoassay in a central laboratory. We used an AUTO-GA Immulite 2000, Siemens, Eschborn, Germany. At T 3 , serum insulin was analysed (at the University of Bremen, Centre for Biomolecular Interactions Bremen) by multiplex analysis with electrochemiluminescence technology from Meso Scale discovery (MSD) using a MULTI-SPOT® Assay System; Human Leptin, Insulin Assay Kit. The HbA 1c was analysed in K2-EDTA venous blood by high-performance liquid chromatography (AUTOGA variant, Biorad) in a central laboratory at both T 0 and T 3 . HOMA-IR was calculated as fasting insulin (μIU ml -1 ) � FG (mg/dl)/405.

Nagrani R., Foraita R., Wolters M., De Henauw S., Marild S., Molnár D., Moreno L.A., Russo P., Tornaritis M., Veidebaum T., Ahrens W, & Marron M. (2022). Longitudinal association of inflammatory markers with markers of glycaemia and insulin resistance in European children. Diabetes/metabolism research and reviews, 38(3).

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