General electric mr750

Manufactured by GE Healthcare

Sourced in Germany

The General Electric MR750 is a magnetic resonance imaging (MRI) system designed for clinical use. It provides advanced imaging capabilities to support healthcare professionals in their diagnostic and treatment processes. The MR750 utilizes powerful magnetic fields and radio waves to generate detailed images of the body's internal structures without the use of ionizing radiation. The system's core function is to produce high-quality medical images that can be used for a variety of clinical applications.

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Lab products found in correlation

Prisma, by Siemens (3 mentions)

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MR750 (286 citations) General Electric Discovery MR750 (5 citations) 3T MR750 General Electric Scanner (2 citations)

3 protocols using general electric mr750

Multimodal Neuroimaging Protocol for Pregenual ACC and Striatal Analysis

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Participants were familiarized with the MRI settings and practiced the SST using a dummy scanner at T1. At T2, the task was practiced again if needed. The data were acquired from the three study locations, all using 3 Tesla scanners (Siemens Trio and Siemens Prisma, Siemens, Erlangen, Germany; Philips Achieva, Philips Medical Systems, Best, The Netherlands; General Electric MR750, GE Medical Systems, Milwaukee, Wi, USA). Structural T1-weighted scans were acquired based on the ADNI GO protocols (Jack et al., 2008 (link), Jack et al., 2010 ), which were used for registration of the functional scans and voxel placement for the ¹H-MRS.
Spectra were acquired using a point resolved spectroscopy sequence (PRESS) with a chemically selective water suppression (CHESS) (Haase et al., 1985 ) from the midline pregenual ACC and the left dorsal striatum covering caudate and putamen with an 8 cm³ voxel size (2 × 2 × 2). Voxel locations were adjusted to maximize the amount of grey matter (GM) and minimize the cerebrospinal fluid (CSF) content to keep the quality of the data as high as possible. The locations of all voxel placements are shown in the Supplementary material (Fig. S2 and S3). Details on the structural, functional and ¹H-MRS scan parameters can be found in Table S1 in the Supplementary material.

Hollestein V., Buitelaar J.K., Brandeis D., Banaschewski T., Kaiser A., Hohmann S., Oranje B., Gooskens B., Durston S., Williams S.C., Lythgoe D.J, & Naaijen J. (2021). Developmental changes in fronto-striatal glutamate and their association with functioning during inhibitory control in autism spectrum disorder and obsessive compulsive disorder. NeuroImage : Clinical, 30, 102622.

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Multisite Neuroimaging Protocol for Glutamate Quantification

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Participants were familiarized with the MRI settings and practice of the SST using a dummy scanner at T1. The data were acquired from the three study locations, all using 3 Tesla scanners (Siemens Trio and Siemens Prisma, Siemens, Erlangen, Germany; Philips 3 T Achieva, Philips Medical Systems, Best, The Netherlands; General Electric MR750, GE Medical Systems, Milwaukee, Wi, USA). Structural T1-weighted scans were acquired based on the ADNI GO protocols (36, (link)37) (link), which were used for registration of the functional scans and voxel placement for the 1 H-MRS. Details on the structural, functional and 1 H-MRS scan parameters can be found in Table 1.
Glutamate concentrations were measured using 1 H-MRS at the midline pregenual ACC and left dorsal striatum covering caudate and putamen, with a voxel size of 8cm 3 (2´2´2).
Voxel locations were adjusted to maximize the grey matter (GM) content and minimize the cerebrospinal fluid (CSF) content to keep the quality of the data as high as possible. The locations of all voxel placements are shown in Figure 2. Across all sites, the proton spectra were acquired using a point resolved spectroscopy sequence (PRESS) with the chemically selective suppression (CHESS) water suppression technique (38) (link), details can be seen in Table 1.

Hollestein V., Buitelaar J.K., Brandeis D., Banaschewski T., Kaiser A., Hohmann S., Oranje B., Gooskens B., Durston S., Lythgoe D.J., & Naaijen J. (2020). Longitudinal alterations in fronto-striatal glutamate are associated with functioning during inhibitory control in autism spectrum disorder and obsessive compulsive disorder.

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Resting-State fMRI Acquisition Protocol

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Participants were asked to refrain from using stimulant medication and caffeine from 48 hours before testing. On the testing day, they were first familiarized with the MRI context in a mock scanner. Resting state T2-weighted functional scans and reference T1-weighted anatomical scans were acquired on 3 Tesla MRI scanners (Nijmegen site: Siemens Prisma, Siemens, Erlangen, Germany; London site: General Electric MR750, GE Medical Systems, Milwaukee, WI, USA).
Either a 32-channel (Nijmegen) or 8-channel (London) head coil was used. For the anatomical scan the sequence was based on the ADNI GO protocols (Jack et al. 2008 ) and for the R-fMRI we used a multi-echo sequence (Kundu et al. 2012) . The scanning parameters are detailed in Supplementary Table 1 and were matched as closely as possible across the sites. During the R-fMRI scan, the light was dimmed, a fixation cross was placed on the screen, and children were asked to keep their eyes open.

Akkermans S.E.A., Rheinheimer N., Bruchhage M.M.K., Durston S., Brandeis D., Banaschewski T., Boecker-Schlier R., Wolf I., Williams S.C.R., Buitelaar J.K., van Rooij D, & Oldehinkel M. (2019). Frontostriatal functional connectivity correlates with repetitive behaviour across autism spectrum disorder and obsessive-compulsive disorder. Psychological medicine, 49(13).

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