TGF-β signaling was inhibited in live embryos by introducing the indicated concentration of SB505124 (Selleckchem, solubilized in DMSO) directly into their growth media at 52 hpf. For inhibition of Ctsk, embryos were also treated with the indicated concentration of Odanacatib (Selleckchem, solubilized in DMSO) at 52 hpf. Embryos were treated for 1–2 days. In all cases, WT control embryos were treated with an equivalent amount of DMSO (0.1%). For all treatment experiments, embryos were staged and synchronized by age within the first hours after fertilization and again before 24 hpf.
Odanacatib
Manufactured by Selleck Chemicals
Odanacatib is a laboratory equipment product. It functions as a cathepsin K inhibitor.
Automatically generated - may contain errors
Lab products found in correlation
2 protocols using odanacatib
1
Inhibiting TGF-β and Ctsk in Embryonic Development
2
Characterizing Odanacatib's Inhibitory Effects
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CtsK inhibitor Odanacatib (10 nM and 100 nM; MK0822; Catalog number S1115, Selleckchem; CAS No. 603139–19-1).
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