Elecsys e411

Manufactured by Roche

Sourced in Germany

The Elecsys e411 is a compact and fully automated immunoassay analyzer developed by Roche. It is designed for routine diagnostic testing in clinical laboratories. The Elecsys e411 performs a wide range of immunoassay tests accurately and efficiently.

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Lab products found in correlation

Architect c8000, by Abbott (2 mentions) Advia 1800, by Siemens (1 mentions) Advia centaur, by Siemens (1 mentions) Dpc immulite 2000, by Siemens (1 mentions) Vacuette z serum clot activator, by Greiner (1 mentions)

Spelling variants of this product

Elecsys modular analytics Cobas e411 (7 citations) ELECSYS Cobas e411 (4 citations) Elecsys cobas® e411 analyzer (2 citations)

5 protocols using elecsys e411

Biomarkers of Metabolic Health

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All study participants received 20-cc whole blood sampling after overnight fast. Insulin-like growth factor-1 (IGF-1, ng/mL) and total testosterone (ng/dL) were analyzed by chemiluminescence immunoassay analyzer (DPC Immulite 2000, Siemens, USA and ADVIA Centaur, Siemens, USA respectively). SHBG and dehydroepiandrosterone sulfate (DHEA-S, ug/dL) were measured by electrochemiluminometry (Roche Elecsys e411; Roche, Indianapolis, IN). Free androgen index (FAI) was defined as total testosterone (nM/L) divided by sex hormone binding globulin (SHBG, nM/L).
High-sensitivity C-reactive protein (hsCRP, mg/dL) was measured by an automatic analyzer (ADVIA 1800, Siemens, USA). Serum level of insulin (uIU/mL) and 25-OH vitamin D(25-OH VitD, ng/mL) were analyzed by chemiluminescence immunoassay (ADVIA Centaur, Siemens, USA, and Diasorin Liaison, Italy respectively). Insulin resistance was estimated by the Homeostatic model assessment model (HOMA-IR) and was calculated as (glucose (mg/dL) × insulin (uIU/mL))/405.

Hwang A.C., Zhan Y.R., Lee W.J., Peng L.N., Chen L.Y., Lin M.H., Liu L.K, & Chen L.K. (2016). Higher Daily Physical Activities Continue to Preserve Muscle Strength After Mid-Life, But Not Muscle Mass After Age of 75. Medicine, 95(22), e3809.

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Biomarker Analysis of Blood Samples

Cited 1 time

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Blood samples were obtained at admission to the hospital. The blood was collected in 6 mL tubes, VACUETTE^® Z Serum Clot Activator (Greiner Bio-one GmbH, Kremsmuenster, Austria). Beckman Coulter instrument AU 2700, 2007 (Brea, CA, SAD) and Architect c8000, Abbott 2013 (Chicago, IL, SAD) were used for analysis of serum albumin, creatinine, urea, CRP, total plasma cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides. GFR was calculated as previously described35 (link). Electrochemiluminescence immunoassay with Elecsys e411 (Roche Diagnostics GmbH, Mannheim, Germany) was used for NT-proBNP quantification.

Potočnjak I., Degoricija V., Trbušić M., Pregartner G., Berghold A., Marsche G, & Frank S. (2017). Serum Concentration of HDL Particles Predicts Mortality in Acute Heart Failure Patients. Scientific Reports, 7, 46642.

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Comprehensive Blood Analysis Protocol

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Whole blood samples were drawn by venepuncture, and blood analysis (including complete blood count, blood gas analysis, metabolic and electrolyte panel, urea nitrogen, creatinine, lipid profile, C-reactive protein, urinalysis and NT-proBNP) was done at the time of admission. Serum electrolyte, creatinine, urea, total plasma cholesterol, LDL cholesterol, HDL cholesterol and triglycerides were measured using a Beckman Coulter instrument AU 2700, 2007 (Brea, CA, US) and Architect c8000, Abbott 2013 (Chicago, IL, US). Total blood count was automatically counted by Coulter:Counter S plus junior (Coulter Electronics Limited, Luton, England). Nt-proBNP was determined by electrochemiluminescence immunoassay (ECLIA) with Elecsys e411 (Roche Diagnostics GmbH, Mannheim, Germany). The results were shown in pg/mL.

Radulović B., Potočnjak I., Terešak S.D., Trbušić M., Vrkić N., Malogorski D., Starčević N., Milošević M., Frank S, & Degoricija V. (2016). Hypochloraemia as a predictor of developing hyponatraemia and poor outcome in acute heart failure patients. International journal of cardiology, 212, 237-241.

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Diagnostic Biomarkers in Emergency Care

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At first encounter in emergency department, sociodemographic status, past medical history, signs and symptoms, as well as chest radiography and electrocardiography were obtained in each patient. Echocardiography was performed on the first day post admission. Blood samples were obtained from medial cubital vein for routine laboratory assays at admission (complete blood count, metabolic and electrolyte panel, blood urea nitrogen, creatinine, lipid profile, and NT-proBNP). Standard serum electrolytes, renal panel and serum lipids were tested on Beckman Coulter instrument AU 2700, 2007 (Brea, CA, US) and Architect c8000, Abbott 2013 (Chicago, IL, US). Elecsys e411 (Roche Diagnostics GmbH, Mannheim, Germany) measured the level of Nt-proBNP. Admission chloride, total plasma cholesterol, LDL-c, HDL-c and triglycerides were defined as values obtained on presentation at emergency department. Hypochloremia was defined as serum concentration of chloride lower than 98 mmol/L. Total cholesterol lower than 5 mmol/L was considered normal, and so was the value of LDL-c lower than 3 mmol/L. HDL-c concentration higher than 1.2 mmol/L in women and higher than 1.00 mmol/L in men was set as normal. Serum concentration of triglycerides higher than 1.7 mmol/L was a high value.
All data were recorded on days 2, 3 and 7 of hospital stay, and follow up measurements were performed at three months.

Radulović B., Potočnjak I., Dokoza Terešak S., Trbušić M., Vrkić N., Huršidić Radulović A., Starčević N., Milošević M., Degoricija V, & Frank S. (2019). CHOLESTEROL AND CHLORIDE IN ACUTE HEART FAILURE. Acta Clinica Croatica, 58(2), 195-201.

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Serum Thyroid Hormone Measurement

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TSH and free T4 were measured in serum obtained from five animals per experimental group by electrochemiluminescence immunoassay (ECLIA) direct sandwich assay, and competitive assay, respectively, automated in an Elecsys e411 (Roche Diagnostics GmbH, Sandhofer Strasse 116, D-68305 Mannheim). Overall intra-assay and inter-assay coefficients of variation were <3% and <7%, and <6% and <10%, respectively. Assay sensitivity was 0.014 microUI/ml and 0.42 ng/dl, respectively.

Vidal V., Puente A., García-Cerro S., García Unzueta M.T., Rueda N., Riancho J, & Martínez-Cué C. (2021). Bexarotene Impairs Cognition and Produces Hypothyroidism in a Mouse Model of Down Syndrome and Alzheimer’s Disease. Frontiers in Pharmacology, 12, 613211.

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