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Ms436

Manufactured by Cayman Chemical
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The MS436 is a laboratory instrument designed for mass spectrometry analysis. It provides precise measurement and detection of chemical compounds.

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Lab products found in correlation

Mouse monoclonal caspase 8, by Cell Signaling Technology (1 mentions) Survivin, by Cell Signaling Technology (1 mentions) Soluble recombinant human trail, by Thermo Fisher Scientific (1 mentions) Gapdh antibody, by Merck Group (1 mentions) Bcl 2 antibody, by Santa Cruz Biotechnology (1 mentions) Cycloheximide (chx), by Merck Group (1 mentions) Mg132, by Merck Group (1 mentions) C myc, by Cell Signaling Technology (1 mentions) Otx015, by Cayman Chemical (1 mentions) Mouse monoclonal caspase 3 antibody, by Novus Biologicals (1 mentions) Pfi 1, by Merck Group (1 mentions) Unc0642, by Cayman Chemical (1 mentions) Furin inhibitor 1, by Merck Group (1 mentions)

2 protocols using ms436

1

Detailed Reagents and Antibodies Protocol

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(+)-JQ1 was purchased from ApexBio (Houston, TX). OTX015 and MS436 were purchased from Cayman Chemical (Ann Arbor, MI). Soluble recombinant human TRAIL was purchased from PeproTech, Inc. (Rocky Hill, NJ). MG132, cycloheximide (CHX) and PFI-1 were purchased from Sigma Chemical Co. (St. Louis, MO). Monoclonal anti-FLIP antibody (NF6) was obtained from Alexis Biochemicals (San Diego, CA). Mouse monoclonal caspase-8, PARP, survivin and c-Myc antibodies were purchased from Cell Signaling Technology, Inc. (Danvers, MA). Mouse monoclonal caspase-3 antibody was purchased from Imgenex (San Diego, CA). Rabbit polyclonal DR5 antibody was obtained from ProSci Inc. (Poway, CA). Mouse monoclonal DR4 antibody (B-N28) was purchased from Diaclone (Stamford, CT). Rabbit polyclonal Mcl-1 and Bcl-XL/S and mouse monoclonal Bcl-2 antibody were purchased from Santa Cruz Biotechnology, Inc. (Santa Cruz, CA). Tubulin and GAPDH antibodies were purchased from Sigma Chemical Co. and Trevigen Inc. (Gaithersburg, MD), respectively.
Yao W., Yue P., Khuri F.R, & Sun S.Y. (2015). The BET bromodomain inhibitor, JQ1, facilitates c-FLIP degradation and enhances TRAIL-induced apoptosis independent of BRD4 and c-Myc inhibition. Oncotarget, 6(33), 34669-34679.
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2

Epigenetic Screening Compound Library Protocol

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The epigenetic screening compound Library (96-well format) was purchased from Cayman Chemical (item# 11076, batch# 0479267), each compound was provided in DMSO at a concentration of 10 mM. The library consists of 146 compounds from four major categories according to their enzyme targets, including 18 histone acetyltransferase (HAT) inhibitors, 55 histone deacetylase (HDAC) inhibitors, 32 histone lysine methyltransferase (KMT) inhibitors, 13 histone lysine demethylases (KDM) inhibitors, and 28 other epigenetic compounds. Compound hits UNC0642, CAY10433, and MS436 were repurchased from Cayman Chemical. BRD4 degrader dBET1 (cat# SML2687) and Furin inhibitor I (cat# 344930) were purchased from Sigma-Aldrich. BRD4 degrader MZ-1 (cat# S8889) and HBV replication inhibitor lamivudine (3TC) (cat# S1706) were purchased from Selleck Chemicals.
Yu X., Long Q., Shen S., Liu Z., Chandran J., Zhang J., Ding H., Zhang H., Cai D., Kim E.S., Huang Y, & Guo H. (2023). Screening of an epigenetic compound library identifies BRD4 as a potential antiviral target for hepatitis B virus covalently closed circular DNA transcription. Antiviral research, 211, 105552.
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