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Benazepril hydrochloride

Manufactured by Novartis
Sourced in China

Benazepril hydrochloride is a white crystalline powder used as a pharmaceutical ingredient. It is the hydrochloride salt of benazepril, an angiotensin-converting enzyme (ACE) inhibitor medication. Benazepril hydrochloride is primarily used in the treatment of hypertension and congestive heart failure.

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3 protocols using benazepril hydrochloride

1

Diabetic Kidney Disease Pathogenesis

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Experimental Materials STZ (Sigma, St. Louis, MO, USA), blood glucose meter (Sinocare Inc, Hunan, China), albumin and creatinine assay kits (Bioassay Systems, Hayward, CA, USA), insulin (Wanbang Biochemical Pharmaceutical Inc, Jiangsu, China), benazepril hydrochloride (Novartis Pharmaceutical Co. Ltd., Peking, China), hematoxylin and eosin (H&E) staining kit, Sirius red (SR) staining kit, and bovine serum albumin (BSA; Solarbio Life Sciences, Peking, China), rabbit polyclonal anti-mouse HMGN1, CD68, F4/80, α-SMA, and ED-1 antibody (MDL Biotech Application Co. Ltd., Peking, China), goat anti-rabbit horseradish peroxidase conjugate secondary antibody (Proteintech Group, Inc., Chicago, IL, USA), in situ hybridization (ISH) assay kit (Boster Biological Technology Co. Ltd., Wuhan, Hubei, China), and diaminobenzidine (DAB) staining kit (Zhongshan Jinqiao Biotechnology Co. Ltd., Beijing, China) were used.
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2

ADR-Induced Kidney Injury Pathway

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Adriamycin (ADR) was purchased from Shanghai Wokai Chemical Reagent Co., Ltd (shanghai, China); CA was purchased from Sigma-Aldrich, Inc (St. Louis, United States); Benazepril hydrochloride was purchased from Beijing Novartis Pharmaceutical Co., Ltd (beijing, China); Urea nitrogen kit and creatinine kit were purchased from CHANGCHUN HUILI BIOTECH CO., Ltd (changchun, China); Urinary protein quantitative kit was purchased from Nanjing Jiancheng Bioengineering Institute (nanjing, China); HE staining fluid was purchased from Wuhan Google Biotechnology Co. Ltd (wuhan, China); Primary antibody: p38 MAPK, p-p38 MAPK and GAPDH were purchased from Cell Signaling Technology, Inc. (Danvers, Massachusetts, United States); Secondary antibody was purchased from Beyotime Biotechnology Co., Ltd (shanghai, China).
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3

Extraction and Identification of A. mongolica

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The seeds of A. mongolica were collected from Alashan Yabulai Gobi (104°48′09″ E 40°11′24″N) and identified as A. mongolica by Professor Shi Song-li of School of Pharmacy, Baotou Medical College. Following reagents were purchased: benazepril hydrochloride (Beijing Novartis Pharmaceutical Co., Ltd., China); pentobarbital sodium (Merck, Germany); sodium carboxymethyl cellulose (Analytical Pure, Tianjin Kaitong Chemical Reagent Co., Ltd., China); penicillin sodium for injection (North China Pharmaceutical Co., Ltd., China, batch number: F7116323); HE and Masson dyeing kits (Nanjing Jiancheng Technology Co., Ltd., China); methanol (LC-MS grade, Honeywell, USA, 67-56-1); acetonitrile (LC-MS grade, Honeywell, 75-05-8); and formic acid (LC-MS grade, Sigma-Aldrich, USA, 64-18-6).
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