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31 protocols using copper 1 iodide

1

Synthesis of Colloidal Semiconductor Nanocrystals

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Copper (I) iodide (CuI, 99.99%), indium acetate (In (AC)3, 99.99%), zinc acetate (Zn (ac)2, 99.99%), 1-octadecence (ODE, 90%), 1-octanethiol (OT, 98%), zinc stearate (Zn-St, 99.99%), oleic acid (OA, 90%) and 2-Ethylhexanoic acid (EHA, 99%) were purchased from Sigma-Aldrich. Octane, ethanol and acetone were purchased from Aladdin. All the chemicals were used without further purification.
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2

Synthesis and Characterization of Nanoparticles

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Copper(I) iodide (CuI, 99.9%), indium(III) acetate (In(OA)3, 99.9%), zinc stearate (ZnO, 12.5–14%), 1-dodecanethiol (DDT, 98%), oleylamine (97%), oleic acid (OA, 90%), 1-octadecene (ODE, 90%), calcein-AM, propidium iodide (PI), p-nitrosodimethylaniline, and 2′,7′-dichlorodihydrofluorescein diacetate (DCFH-DA) were purchased from Sigma-Aldrich and used as received without further purification. DSPE-PEG-2K was purchased from Yarebio (Shanghai, China). Deionized water (18.2 MΩ·cm resistivity at 25 °C) was used for all tests.
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3

Evaluating Abraxane® and free PTX

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Abraxane® (nab-PTX- NPs containing albumin-bound PTX) was purchased from Celgene (Uxbridge, UK) and PTX was purchased from Mylan (Saint-Priest, France) for treatment efficacy study using free PTX. Triethylamine (≥99.5%), copper (I) iodide (99.999%), Nile Red (NR) for microscopy, BSA and bovine liver catalase were all obtained from Sigma-Aldrich (Prague, Czech Republic) and were used without further purification. AlexaFluor® 647 was purchased from Life Technologies (Carlsbad, CA, USA). For NP encapsulation, PTX was purchased from Aurisco (Yangzhou, People’s Republic of China). Polymethylmethacrylate (PMMA) standards were purchased from Polymer Source (Canada). All solvents, unless otherwise stated, were used without further purification.
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4

Synthesis of Tribromobenzene Derivative

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1,3,5‐tribromobenzene (98%), tetrakis(triphenylphosphine)palladium (0) (99%), copper(I) iodide (≥99.5%), trimethylsilyl acetylene (≥98.0%), sodium hydroxide (≥99.0%), methyl alcohol (HPLC, ≥99.9%), hexane (99%), poly (methyl methacrylate), sodium molybdate (≥98.0%), optiPrep density gradient medium were purchased from Sigma‐Aldrich Inc. and used without purifications. The details synthesis processes are in Supporting Information.
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5

Synthesis of Functionalized Organic Compounds

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1,3,5-Tribromobenzene (98%), trimethylsilyl-acetylene (98%), trimethylsilyl azide (94%), and diethylamine (99%) were purchased from Alfa Aesar (Ward Hill, MA, USA). Sodium nitrite (97%), phosphate buffered saline (PBS) tablets, and copper(II) chloride dihydrate were obtained from EMD Chemicals (Gibbstown, NJ, USA). Glutathione (98%) was purchased from AMRESCO (Solon, OH, USA). Low molecular weight chitosan (96% deacetylated) and copper(I) iodide (99.5%) were purchased from Sigma-Aldrich (St. Louis, MO, USA). Deionized water (18.2 MΩ·cm) was obtained from a Millipore Direct-Q water purification system (EMD Millipore, Billerica, MA, USA). Ultrahigh purity nitrogen and oxygen gases were supplied by Airgas (Denver, CO, USA). Bis(triphenylphosphine)-palladium(II) dichloride (98%) was purchased from TCI America (Portland, OR, USA). All materials were used as received without any further purification.
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6

Synthesis of Conjugated Polymers

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Toluene
(anhydrous, 99.8%),
mEthanol (anhydrous, 99.8%), borane–tetrahydrofuran complex
solution 1 M in tetrahydrofuran (BH3OC4H8, 1 M in tetrahydrofuran), 1,4-diethynylbenzene (C8H6, 96%), 1-octene (C10H6, 96%),
silica-gel [(40–63) μm], magnesium sulfate (MgSO4, anhydrous, >99.0%), 2,5-dibromo-3-hexylthiophene (97%),
bis(triphenylphosphine)palladium(II) dichloride (Pd(PPh3)2Cl2, 98%), copper(I) iodide (CuI, >98.0%),
and triethylamine (TEA) (N(C2H5)3, 99.0%) were purchased from Sigma-Aldrich. Ethanol (C2H5OH, 99.5%), n-hexane (C7H16, 95%), mEthanol (CH3OH, 99.5%), and chloroform
(CHCl3, 99.7%) were purchased from Dae-Jung (South Korea),
and hydrofluoric acid [(48–51)%] was purchased from J.T. Baker.
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7

Synthesis of Colloidal Metal-Chalcogenide Nanocrystals

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Copper(i) iodide (CuI, 99.99%), indium(iii) acetate (In(OAc)3, 99.99%), zinc(ii) acetate (Zn(OAc)2, 99.99%), 1-dodecanethiol (99.9%), 1-octadecylamine (97%), 1-octadecene (90%), and γ-(mercaptopropyl)trimethoxysilane (95%) were purchased from Sigma-Aldrich Corp. (USA) and used without further purification.
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8

Colloidal Copper Sulfide Synthesis

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Copper(i) iodide (CuI, 99.5%), copper(i) acetate (CuOAc, 97%), oleylamine (OAm, 70%), sulfur powder (99.98%), tetrachloroethylene (TCE, spectroscopy grade Uvasol), and diphenylether (DPE, 99%) were purchased from Sigma-Aldrich; toluene (99.5%) and methanol (>99.9%) were purchased from VWR, and acetone (99%) was purchased from Th. Geyer. Chemicals were used as received without additional purification.
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9

Synthesis of Diverse Chemical Compounds

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Urea was purchased from Merck; thioUrea was purchased from Apolda (DDR); diethyl ethylmalonate was purchased from J&K (Germany); sodium azide, sodium hydride, copper(I) iodide, and potassium tert-butoxide were purchased from Sigma Aldrich (Germany); diethyl malonate, 10-bromo-1-decene, 5-cloro-1-pentyne, and diisopropylethylamine were purchased from TCI (Belgium). All chemicals listed here were used without any purification unless otherwise stated. Solvents handling and the chemicals that are not mentioned here can be found in the Supplementary Materials.
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10

Synthesis of Colloidal Nanocrystals

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Copper(I) iodide (CuI, ≥ 99.5%), iron(III)
acetylacetonate (Fe(acac)3, ≥ 99.9%), 1-octadecene
(ODE, technical grade, 90%), oleylamine (OLAM, technical grade, 70%),
and 1-dodecanethiol (DT, ≥ 98%) were purchased from Sigma-Aldrich.
Tri-n-octylphosphine (TOP, 97%) was procured from Strem Chemicals.
α-Methoxy-ω-mercapto polyethylene glycol (SH-PEG-OCH3, MW: 2000 g mol–1) was purchased from Rapp
Polymere. Anhydrous chloroform, methanol, and isopropanol were purchased
from Carlo Erba reagents. All chemicals were used as received. A Milli-Q
Millipore system was used for the purification of water (resistivity
≥ 18 MΩ cm).
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