Tim trio scanner

Manufactured by Siemens

Sourced in Germany, United States

The TIM Trio scanner is a medical imaging device developed by Siemens. It is a magnetic resonance imaging (MRI) system that provides high-quality imaging capabilities. The TIM Trio scanner is designed to capture detailed images of the body's internal structures, which can be used for diagnostic purposes.

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348 protocols using tim trio scanner

Harmonized T1-Weighted MRI Acquisition Protocols

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MRI acquisition was performed in every centre to acquire T₁-weighted images. The Montreal cohort underwent T₁-weighted imaging with a 3 T Siemens TIM Trio scanner with a 12-channel head coil, magnetization-prepared rapid acquisition gradient echo (MPRAGE) sequence with the following parameters: repetition time (TR): 2300 ms, echo time (TE): 2.91 ms, flip angle: 9°, and voxel size: 1 mm³ isotropic. The Paris cohort underwent T₁-weighted imaging with a 3 T Siemens TIM Trio scanner with a 12-channel head coil, MPRAGE sequence: TR: 2300 ms, TE: 4.18 ms, inversion time (TI): 900 ms, flip angle: 9°, and voxel size: 1 mm³ isotropic; or a 3 T PRISMA Fit scanner with a 64-channel head coil, MP2RAGE sequence: TR: 5000 ms, TE: 2.98 ms, TI: 700 and 2500 ms, flip angle: 4° and 5°, GRAPPA: 3, and voxel size: 1 mm³ isotropic. The Sydney cohort was imaged with a GE Discovery MR750 3 T scanner with an 8-channel head coil, BRAVO sequence: TR: 5800 ms, TE: 2.6 ms, flip angle: 12°, and voxel size: 1 mm³ isotropic. The Aarhus cohort was imaged with a 3 T Siemens MAGNETOM Skyra scanner with a 32-channel head coil, MPRAGE sequence: TR: 2420 ms, TE: 3.7 ms, TI: 960 ms, flip angle: 9°, and voxel size: 1 mm³ isotropic. The T₁-weighted images from the Parkinson’s Progression Markers Initiative cohort are described elsewhere.^{24 (link)}

Rahayel S., Tremblay C., Vo A., Misic B., Lehéricy S., Arnulf I., Vidailhet M., Corvol J.C., Gagnon J.F., Postuma R.B., Montplaisir J., Lewis S., Matar E., Ehgoetz Martens K., Borghammer P., Knudsen K., Hansen A.K., Monchi O., Gan-Or Z, & Dagher A. (2023). Mitochondrial function-associated genes underlie cortical atrophy in prodromal synucleinopathies. Brain, 146(8), 3301-3318.

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Multimodal Brain Imaging Protocol

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Each subject participated in a minimum of 5 sets of scans across multiple sessions and separate behavioral training sessions. In addition to the 4 fMRI experiments, high-resolution structural scans were collected to support anatomical reconstruction of the cortical hemispheric surfaces. Imaging was performed at the Center for Brain Science Neuroimaging Facility at Harvard University on a 3-T Siemens Tim Trio scanner with a 32-channel matrix coil. A high-resolution (1.0 × 1.0 × 1.3 mm) magnetization-prepared rapid gradient-echo sampling structural scan was acquired for each subject. The cortical surface of each hemisphere was computationally reconstructed from this anatomical volume using FreeSurfer software (http://surfer.nmr.mgh.harvard.edu/). For functional studies, T2*-weighted gradient echo, echo-planar images were collected using 42 3-mm slices (0% skip), oriented axially (time echo 30 ms, time repetition [TR] 2600 ms, in-plane resolution 3.125 × 3.125 mm). In the visual spatial task, 7 of 11 subjects were scanned on an identically equipped Siemens Tim Trio scanner at the Martinos Center for Biomedical Imaging at Massachusetts General Hospital.

Michalka S.W., Kong L., Rosen M.L., Shinn-Cunningham B.G, & Somers D.C. (2015). Short-term memory for space and time flexibly recruit complementary sensory-biased frontal lobe attention networks. Neuron, 87(4), 882-892.

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CARE Study Diffusion MRI Acquisition

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The neuroimaging acquisition protocol and longitudinal MRI quality assurance/control followed the original CARE design described in previous publications.^{8 (link),9 (link),19 (link)} In brief, for diffusion MRI, scans were performed on participants on Siemens MAGNETOM 3T scanners across 3 study sites, including the University of North Carolina (UNC), the University of California Los Angeles (UCLA), and Virginia Tech (VT). Throughout the CARE study, a single 3T MRI scanner was used at each site. Both UNC and UCLA used Siemens Tim Trio scanners that were upgraded to Prisma in 2016; nevertheless, the MRI parameters were made identical before and after the upgrade. VT used a Siemens Tim Trio scanner for the duration of the study. A single-shot echo-planar imaging sequence with a twice-refocused spin echo was used. The diffusion-encoding scheme consisted of 30 directions at a b value of 1,000 s/mm² and 8 b₀ (b value = 0 s/mm²). One of the b₀ volumes was acquired with a reversed phase-encoding direction. Other MRI parameters were echo time = 98 milliseconds, repetition time = 7,900 milliseconds, field-of-view = 243 mm, matrix size = 90 × 90, whole brain coverage of 60 slices with a slice thickness of 2.7 mm, and isotropic resolution of 2.7 mm.

Wu Y.C., Wen Q., Thukral R., Yang H.C., Gill J.M., Gao S., Lane K.A., Meier T.B., Riggen L.D., Harezlak J., Giza C.C., Goldman J., Guskiewicz K.M., Mihalik J.P., LaConte S.M., Duma S.M., Broglio S.P., Saykin A.J., McAllister T.W, & McCrea M.A. (2023). Longitudinal Associations Between Blood Biomarkers and White Matter MRI in Sport-Related Concussion: A Study of the NCAA-DoD CARE Consortium. Neurology, 101(2), e189-e201.

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Multimodal MRI Acquisition Protocol

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Magnetic resonance imaging (MRI) was carried out with a 3 T Siemens Tim Trio scanner (Siemens Medical Solutions, Erlangen, Germany). This included acquisition of a T1-weighted structural MRI (magnetization prepared rapid gradient echo sequence, TE/TR = 3.37/1950 ms, 1 × 1 × 1.2 mm³), diffusion weighted images (single-shot echo planar imaging sequence, TE/TR = 86/8200 ms, 64 diffusion encoding directions at b = 1000 s/mm² and one image at b = 0 s/mm², 2 × 2 × 2 mm³) as well as 6 min functional MRI at resting-state with eyes closed (gradient-recalled echo planar imaging, TE/TR = 30/2000 ms, 3 × 3 × 3 mm³).

Hahn A., Strandberg T.O., Stomrud E., Nilsson M., van Westen D., Palmqvist S., Ossenkoppele R, & Hansson O. (2019). Association Between Earliest Amyloid Uptake and Functional Connectivity in Cognitively Unimpaired Elderly. Cerebral Cortex (New York, NY), 29(5), 2173-2182.

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High-Resolution Imaging of LGI1 Encephalitis

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A 3-dimensional, high-resolution T1-weighted sequence (Magnetization Prepared Rapid Acquisition Gradient Echo; MPRAGE, voxel size 1 × 1 × 1 mm³) and a 3D FLAIR/T2 sequence (Fluid-Attenuated Inversion Recovery; voxel size 1 × 1 × 1 mm³) were acquired for each participant on a 3T Siemens Tim Trio scanner (Siemens, Erlangen, Germany) at the Berlin Center for Advanced Neuroimaging. Eleven LGI1 encephalitis patients and matched controls were examined at the University Hospital Schleswig-Holstein in Kiel on a 3T Philips Achieva scanner using the same sequence. Study site was accounted for as a covariate in the general linear model.

Heine J., Prüß H., Scheel M., Brandt A.U., Gold S.M., Bartsch T., Paul F, & Finke C. (2020). Transdiagnostic hippocampal damage patterns in neuroimmunological disorders. NeuroImage : Clinical, 28, 102515.

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Structural MRI Acquisition Protocols

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Subjects for the Jena-1 sample underwent high–resolution T1-weighted MRI on a 3 Tesla Siemens Tim Trio scanner (Siemens, Erlangen, Germany) using a standard quadrature head coil and an axial 3-dimensional magnetization prepared rapid gradient echo (MP-RAGE) sequence (TR 2,300 ms, TE 3.03 ms, α 9°, 192 contiguous sagittal slices, FoV 256 mm, voxel resolution 1 × 1 × 1 mm; acquisition time 5:21 min).
Participants of the Jena-2 sample were scanned on a Siemens Prisma fit system (Siemens, Erlangen, Germany), which was based on the above Siemens Tim Trio scanner, after undergoing a significant upgrade (both hardware and software). The structural scan was acquired with an MP-RAGE sequence with similar parameters (TR 2,300 ms, TE 2.07 ms, α 9°, 192 contiguous sagittal slices, FoV 256 mm, voxel resolution 1 × 1 × 1 mm; acquisition time 5:21 min) as part of a 25 min imaging session.
The Verona-Milano sample MRI scans were acquired with a 3T Magnetom Allegra Syngo MR 2004A (Siemens, Erlangen, Germany) also using a standard head coil for radio frequency transmission and reception of the MRI signal. An MP-RAGE sequence was acquired (TR 2,060 ms, TE 3.93 ms, α 15°, 160 contiguous sagittal slices, FoV 256 mm, voxel resolution 1 × 1 × 1 mm, acquisition time 7:32 min). The scan was part of a MRI protocol of about 50 min total duration.
All scans were checked to exclude imaging artifacts.

Besteher B., Squarcina L., Spalthoff R., Bellani M., Gaser C., Nenadić I, & Brambilla P. (2018). Subclinical Agoraphobia Symptoms and Regional Brain Volumes in Non-clinical Subjects: Between Compensation and Resilience?. Frontiers in Psychiatry, 9, 541.

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Neuroimaging of Maze Navigation and Effort-based Decision Making

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Stimuli were presented via back-projection mirror, and participants completed the maze-navigation and effort-choice task using an MR-compatible 4-button box (Current Designs Inc). Inflatable pads (Multipad 01; Pearltec AG) placed around participants’ heads were used to minimize head motion.
Participants were scanned in a 3-Tesla Siemens TIM Trio scanner (Siemens AG) with a 32-channel head-coil using multiband structural and functional imaging^{56 (link)}. Each session began with a 3-plane localizer scan for slice alignment, and a single-shot, high-resolution structural MPRAGE sequence (TR/TE=1900/2.27ms; flip angle=9°; FoV=250×250mm; 192×1.0mm slices). Blood oxygen level dependent functional images were acquired with T2*-weighted EPI sequences with a multiband acceleration factor of 4 (TR/TE=1000/30.0ms; flip angle=65°; FoV=220×220mm; 52×3.00mm slices).

Suzuki S., Lawlor V.M., Cooper J.A., Arulpragasam A.R, & Treadway M.T. (2020). Distinct Regions of the Striatum Underlying Effort, Movement Initiation, and Effort Discounting. Nature human behaviour, 5(3), 378-388.

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3T fMRI Data Acquisition and Preprocessing

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MRI data was recorded using a 12-channel head coil on a 3T Siemens Tim Trio Scanner (Siemens, Erlangen, Germany). The structural image was acquired with a T1-weighted sequence (MPRAGE; 1-mm³ voxel size). To acquire functional data for the main experiment and the localizer run, we ran a T2*-weighted gradient-echo planar sequence (TR=2, TE=30 ms, 70° flip angle, 3-mm³ voxel size, 37 slices, 20% gap, 192-mm field of view, 64 × 64 matrix size, interleaved acquisition) on the entire brain. fMRI data was preprocessed using SPM8 (https://www._l.ion.ucl.ac.uk/spm/), involving realignment, coregistration and normalization to the structural MNI template brain. We smoothed functional data from the localizer run with an 8 mm FWHM Gaussian kernel, but the data from the main experiment were not smoothed.

Graumann M., Wallenwein L.A, & Cichy R.M. (2023). Independent spatiotemporal effects of spatial attention and background clutter on human object location representations. Neuroimage, 272, 120053.

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High-Resolution Multiband fMRI at 3T

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All MRI images were collected at the McLean Brain Imaging Center (Belmont, MA) on a 3.0 Tesla Siemens TIM Trio scanner (Siemens AG, Erlangen, Germany) using a 12-channel head coil. High-resolution structural images (TR=2.1 s, TE=3.3 ms, slices=128, matrix=256×256, flip angle=7°, resolution=1.0 mm×1.0 mm×1.33 mm) were used to register subjects’ imaging data to a standard space. Structural imaging data were read and interpreted by a clinical neuroradiologist to rule out neurological abnormalities.
To increase temporal resolution while ensuring sufficient spatial resolution, fMRI data were acquired using a multiband imaging technique. Each functional run had 32 3.5 mm axial slices with TR/TE=400 ms/30 ms, flip angle=30°, matrix=64×64 on a 220 mm×220 mm FOV, in plane resolution=3.44 mm × 3.44 mm, and multiband factor=8 (Feinberg, Moeller et al. 2010 (link); Tong and Frederick 2014 (link)).

Maher S., Ekstrom T, & Chen Y. (2015). Impaired visual cortical processing of affective facial information in schizophrenia. Clinical psychological science : a journal of the Association for Psychological Science, 4(4), 651-660.

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Neuroimaging of Maze Navigation and Effort-based Decision Making

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