Interleukin il 1β

Manufactured by BioLegend

Sourced in United States

Interleukin (IL)-1β is a pro-inflammatory cytokine that plays a crucial role in the regulation of immune and inflammatory responses. It is involved in the activation of various cell types, including T cells, B cells, and macrophages, and can promote the production of other inflammatory mediators.

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Lab products found in correlation

Tumor necrosis factor α, by BioLegend (2 mentions) Occludin, by Affinity Biosciences (2 mentions) Claudin 3, by Affinity Biosciences (2 mentions) P erk, by Affinity Biosciences (1 mentions) P jnk, by Affinity Biosciences (1 mentions) P ikbα, by Affinity Biosciences (1 mentions) Dextran sulfate sodium salt dss, by MP Biomedicals (1 mentions) Gapdh, by Affinity Biosciences (1 mentions) Neomycin, by Merck Group (1 mentions) Vancomycin, by Merck Group (1 mentions) Metronidazole, by Merck Group (1 mentions) β actin, by Affinity Biosciences (1 mentions) Ampicillin, by Merck Group (1 mentions)

2 protocols using interleukin il 1β

Inflammatory Bowel Disease Protocol

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Dextran Sulfate Sodium Salt (DSS) (Cat#9011-18-1) was purchased from MP Biomedicals (Irvine, CA). Specific antibodies including ZO-1 (1:1000; #AF5145; RRID:AB_2837631), Occludin (1:1000; #DF7504; RRID:AB_2841004), Claudin-3 (1:1000; #AF0129; #RRID:AB_2833313), p65 (1:1000; #BF8005:AB_2846809), p-p65 (1:1000; AB_2834435:AF2006), IKBα (1:1000; #AF5002:AB_2834792), p-IKBα (1:1000; #AB_2834433:AF2002), ERK (1:1000; #AB_2833336:AF0155), p-ERK (1:1000; #AB_2834432:AF1015), JNK (1:1000; #AF6318:AB_2835177), p-JNK (1:1000; #AF3318:AB_2834737), p38 (1:1000; #BF8015:Q16539), p-p38 (1:1000; #AF4001:AB_2835330) and GAPDH (1:1000; #AF7021; AB_2839421) were purchased from Affinity Biosciences (OH, USA). Tumor necrosis factor (TNF)-α (Cat# 430915), interleukin (IL)-1β (Cat# 432615), and interleukin (IL)-6 (Cat# 431307) enzyme-linked immunosorbent assay (ELISA) kits were obtained from Biolegend (San Diego, California, USA). Myeloperoxidas (MPO) (A044-1-1), Superoxide Dismutase (T-SOD) (A001-3-2), Malondialdehyde (MDA) (A003-1-2), Glutathione Peroxidase (GSH-PX) (A005-1-2), and Catalase (CAT) (A007-1-1) assay kit was bought from Nanjing Jiancheng Bioengineering Institute (Nanjing, China).

Yu F., Hu X., Ren H., Wang X., Shi R., Guo J., Chang J., Zhou X., Jin Y., Li Y., Liu Z, & Hu P. (2024). Protective effect of synbiotic combination of Lactobacillus plantarum SC-5 and olive oil extract tyrosol in a murine model of ulcerative colitis. Journal of Translational Medicine, 22, 308.

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Inflammatory Bowel Disease Treatment Protocol

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Inulin was obtained from Yuanyebio Biotechnology Co., Ltd, (S11143, Shanghai, China). Ampicillin (Cat# A5354), neomycin (Cat# N6386), metronidazole (Cat# 16677), vancomycin (Cat# V2002) were bought from Sigma Aldrich (St. Louis, MO, USA). Specific antibodies including ZO-1 (1:1000; #AF5145; RRID: AB_2837631), Occludin (1:1000; #DF7504; RRID: AB_2841004), Claudin-3 (1:1000; #AF0129; RRID: AB_2833313) and β-actin (1:1000; #AF7018; RRID: AB_2839420) were purchased from Affinity Biosciences (OH, USA). S100A8 (#70802) and HDAC3 (#60538) antibody were bought from Cell Signaling Technology (Boston, USA). Acetylated-H3 antibody (Cat# ab47915; RRID: AB_873860) was purchased from Abcam (Cambridge, England). Tumor necrosis factor (TNF)-α (Cat# 430915) and interleukin (IL)-1β (Cat# 432615) enzyme-linked immunosorbent assay (ELISA) kits were obtained from Biolegend (San Diego, California, USA). Myeloperoxidase (MPO) (A044-1-1) assay kit was bought from Nanjing Jiancheng Bioengineering Institute (Nanjing, China,).

Zhao C., Bao L., Zhao Y., Wu K., Qiu M., Feng L., Zhang N., Hu X, & Fu Y. (2023). A fiber-enriched diet alleviates Staphylococcus aureus-induced mastitis by activating the HDAC3-mediated antimicrobial program in macrophages via butyrate production in mice. PLOS Pathogens, 19(1), e1011108.

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