Caerulein hy a0190

Caerulein (HY-A0190) and ML385 (HY-100523) were obtained from MedChem Express (Shanghai, China). Lipopolysaccharide (LPS; L2880) was purchased from Sigma-Aldrich (MO, USA). The antibodies against phospho-nuclear factor-kappa B (p-NF-κB) (3033s), NOD-like receptor protein 3 (NLRP3) (1510s), cleaved interleukin 1β (IL-1β) (52718s), caspase-1 p20 (52718s), and histone H3 (14269s) were purchased from Cell Signaling Technology (MA, USA). The antibodies against nuclear factor E2-related factor 2 (Nrf2) (A0674) and β-tubulin (AC008) were purchased from Abclonal (Wuhan, China).

Sitagliptin (SIT; cat. No. HY-13749) and caerulein (HY-A0190) were obtained from MedChemExpress (Princeton, NJ, USA). Lipopolysaccharide (LPS; from E. coli O127: B8) was purchased from Sigma (St. Louis, MO, USA). Antibodies against LC3-ll (4108), Beclin1 (3738), Atg5 (2630), and NQO1 (62262) were purchased from Cell Signaling Technology Inc. (Beverly, MA, USA); MPO (ab9535), 4-HNE (ab46545), DPP4 (ab187048), and Lamin B1(ab16048) were purchased from Abcam Inc. (Cambridge, MA, USA); and β-actin (66009-1-Ig), Nrf2 (16396-1-AP), Keap1 (10503-2-AP), Ho-1 (10701-1-AP), and p62 (18420-1-AP) were purchased from Proteintech Inc. (Shanghai, China).