B6.129p2 il18tm1aki j

C57BL/6J mice, WBB6F₁-Kit^W/W-v (Kit^W/W-v) mice [and the corresponding control WBB6F₁-Kit^+/+ (Kit^+/+) mice], IL-1R1^−/− (B6.129S7-Il1r1^tm1Imx/J), IL-18^−/− (B6.129P2-Il18^tm1Aki/J) and iDTR^fl/fl mice (C57BL/6-Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/J) were purchased from Jackson Laboratories (Bar Harbor, Me). C57BL/6J (WT) mice were obtained from Jackson Laboratories and either bred at the Stanford University Research Animal Facility or used for experiments after maintaining the mice for at least two weeks in our animal facility. C57BL/6-Kit^W-sh/W-sh mice were originally provided by Peter Besmer (Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA); we then backcrossed these mice to C57BL/6J mice for more than 11 generations (7 (link)). Mcpt8^DTR/+ (and the corresponding control Mcpt8^+/+) mice (8 (link)), IL-1α^−/− (9 (link)), IL-1β^−/− (9 (link)), TNF^−/− (10 (link)) and Cpa3-Cre; Mcl-1^fl/fl mice (and the corresponding control Cpa3-Cre; Mcl-1^+/+ mice) (11 (link)) were all on the C57BL/6 background and bred and maintained at the Stanford University Research Animal Facility. We used age-matched male mice for all experiments. All animal care and experimentation were conducted in compliance with the guidelines of the National Institutes of Health and with the specific approval of the Institutional Animal Care and Use Committee of Stanford University.