Melatonin (Mw: 232,28, λmax: 278 nm) was purchased from Tokyo Chemical Industry (Tokyo, Japan). The new polymers (neat PLA, PLA/PEAd [90/10], PLA/PEAd [75/25], PLA/PBAd [90/10], and PLA/PBAd [75/25]) were kindly donated from the Laboratory of Professor Dimitrios Bikiaris, which is part of the Laboratory of Chemistry and Technology of Polymers and Dyes, in the Department of Chemistry of Aristotle University of Thessaloniki, Greece. HPMC K15M was supplied from Sigma-Aldrich (Steinheim, Germany). Alginic acid sodium salt (low viscosity) and Avicel PH 102 were obtained from Alfa Aesar GmbH & Co. KG (Karlsruhe, Germany). Lactose monohydrate was purchased from Merck (Darmstadt, Germany), whereas magnesium stearate was obtained from Riedel-De Haen (Hannover, Germany). All chemicals were of reagent grade and were used in the study without further purification.
Hpmc k15m
Manufactured by Merck Group
Sourced in Germany
HPMC K15M is a hydroxypropyl methylcellulose (HPMC) product manufactured by Merck Group. It is a water-soluble polymer used as an excipient in pharmaceutical and personal care applications. HPMC K15M is primarily used as a thickening, binding, and stabilizing agent.
Automatically generated - may contain errors
Lab products found in correlation
Magnesium stearate, by Honeywell (3 mentions)
Acetonitrile, by Merck Group (2 mentions)
Lactose monohydrate, by Merck Group (1 mentions)
Pluronic f 127, by Merck Group (1 mentions)
Tween 80, by Merck Group (1 mentions)
Potassium dihydrogen phosphate, by Merck Group (1 mentions)
Dimethyl sulfoxide (dmso), by Merck Group (1 mentions)
Dichloromethane, by Merck Group (1 mentions)
Hpmc k4m, by Merck Group (1 mentions)
Carbopol, by Lubrizol (1 mentions)
Milli q device, by Merck Group (1 mentions)
Hplc grade methanol, by Merck Group (1 mentions)
Hydrochloric acid (hcl), by Merck Group (1 mentions)
Guar gum, by Merck Group (1 mentions)
Chitosan, by Merck Group (1 mentions)
6 protocols using hpmc k15m
1
Melatonin Polymer Characterization
2
Mangiferin Extraction and Characterization
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Mangiferin was acquired from Xi’an Sgonek Biological Technology Co., Ltd., Beijing, China. Pluronic F127, HPMC K15M, and tween 80 of analytical grade were purchased from Sigma-Aldrich GmbH-Darmstadt, Germany. DMSO, acetonitrile, potassium dihydrogen phosphate, and dichloromethane were obtained from Merck-Darmstadt, Germany. All chemicals were of analytical grade.
3
Etamsylate Formulation and Characterization
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Etamsylate was purchased from Sigma–Aldrich Co., St. Louis, MO, USA. Dicynone® tablets (500 mg etamsylate) was purchased from local market (OM Pharma, Geneva, Switzerland). Carbopol was obtained from Lubrizol Advanced Materials, India. Microcrystalline cellulose (MCC) from Hercules Inc., Wilmington, MA, USA. HPMC K4M and HPMC K15M were purchased from Sigma Aldrich, Germany. Sodium alginate and xanthan gum were obtained from Loba Chemicals, Mumbai, India. Magnesium stearate, starch and talc were purchased from Triveni Interchem, India.
4
Formulation and Characterization of BUP-NTX Tablets
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BUP·HCl (MW: 276.20, pKa = 8.22, >98.0% purity) and NTX·HCl (MW: 377.87 g/mol, pKa = 9.35, >98.0% purity) were purchased from Tokyo Chemical Industry (Tokyo, Japan). HPMC K15M and PEO (MW: 7 × 106 g/mol) were purchased from Sigma-Aldrich (Steinheim, Germany). Eudragit® L100-55 was obtained from Rohm GmbH Pharma Polymers (Darmstadt, Germany). Magnesium stearate was supplied by Riedel-De Haen (Hannover, Germany). HPLC-grade methanol, acetonitrile, potassium dihydrogen phosphate monohydrate and hydrochloric acid (1 M), were obtained from Sigma-Aldrich (Steinheim, Germany). HPLC-grade water was obtained from a Millipore Milli-Q device (Merck S.A. Hellas, Athens, Greece).
5
Formulation and Characterization of Extended-Release Bupropion and Naltrexone
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NTX·HCl (MW: 377.87 g/mol, >98.0% purity) and BUP·HCl (MW: 276.20, >98.0% purity) were purchased from Tokyo Chemical Industry (Japan). Wellbutrin® XR 150 mg (Lot.No. 19F007, GlaxoSmithKline, Industrial & Commercial S.A.) and Wellbutrin® XR 300 mg (Lot.No. F78H, GlaxoSmithKline, Industrial & Commercial S.A.), were donated from a community pharmacy store (T. Papasandas, Athens, Greece). HPMC K15M and PEO (MW: 7 × 106 g/mol) were supplied from Sigma-Aldrich (Steinheim, Germany). Eudragit® L100-55 was obtained from Rohm GmbH Pharma Polymers (Darmstadt, Germany). Ulvan (Cat. No. YU11689) was purchased from Carbosynth® Ltd. (Berkshire, UK) and magnesium stearate was supplied by Riedel-De Haen (Hannover, Germany). All chemicals were of reagent grade and used in this study without further purification.
6
Ondansetron Hydrogel Formulation
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Ondansetron was obtained as a gift from Aurobindo Pharma Ltd. Gaddapotharam, Andhra Pradesh. HPMC K 15 M, Chitosan & Guar gum were procured from Sigma Aldrich. All other substances were of analytical grade. All chemicals were pure and of analytical grade.
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