Magnetom tim trio 3 t mri scanner

All scans were acquired on a Siemens MAGNETOM® Tim Trio 3 T MRI scanner using a 32-channel head coil (Erlangen, Germany). Using a T1-weighted 3D magnetization-prepared rapid gradient-echo (MPRAGE) imaging sequence, high-resolution whole brain anatomical images were obtained sagittally with the following parameters: TR = 1900 ms, TE = 2.52 ms, 1 mm³.
isotropic voxels, imaging matrix = 256 × 256, FOV = 256 mm, flip angle = 9°, and number of slices = 192. A diffusion-weighted echoplanar imaging sequence was used to obtain whole brain DTI data in 64 diffusion directions, including a single reference volume (b₀ = 0 s/mm²), with the following parameters: TR = 6900 ms, TE = 86 ms, 1.5 × 1.5 × 2.0 mm voxels, imaging matrix = 128 × 128, FOV = 192 mm, parallel imaging (GRAPPA with acceleration factor of 3), b = 1000 s/mm², and number of contiguous slices = 56.

This research followed the Declaration of Helsinki doctrine and was approved by the Research Ethics Boards of both The Hospital for Sick Children and York University. Informed consent was obtained from all participants prior to testing and after explanation of the nature and possible consequences of the study.
A high resolution, T₁ weighted three-dimensional MPRAGE anatomical image was obtained for all participants using a Siemens MAGNETOM Tim Trio 3 T MRI scanner with a 32-channel head coil at the Sherman Health Sciences Research Centre at York University (Toronto, Canada). A scan of the entire head was acquired sagittally with the following parameters: rapid gradient echo, 1 mm³ isotropic voxels, TR = 1900 ms, TE = 2.52 ms, 256 × 256 matrix, and flip angle = 9°.