2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) was prepared in-house using a fully automated cassette-based synthesizer (FASTlab, GE Healthcare, Uppsala, Sweden) within the clinical routine production at the Vienna General Hospital, Austria. [11C]SNAP-7941 was synthesized as reported elsewhere using an automated module (TRACERlab FC X Pro, GE Healthcare, Uppsala, Sweden) (25 (link)). All PET-tracers were physiologically formulated and quality-controlled prior to administration. The adrenergic receptor beta ligands carazolol, pindolol and (S)-propranolol hydrochloride were purchased from Sigma-Aldrich (St. Louis, USA). The ADRB3 agonist CL 316,243 was purchased from Tocris Bioscience (Bristol, UK). The unlabeled compounds FE@SNAP and SNAP-7941 were synthesized at the Department of Pharmaceutical Chemistry and at the Department of Organic Chemistry (University of Vienna, Austria). The radioligands 5,7-[3H](-)CGP-12177 and [125I](-)Iodocyanopindolol were purchased from PerkinElmer, Inc. (Waltham, USA). All other reagents and cell culture supplies were purchased from standard commercial sources.
Carazolol
Manufactured by Merck Group
Sourced in United States, France
Carazolol is a laboratory reagent used for analytical purposes. It is a beta-adrenergic antagonist, also known as a beta-blocker. Carazolol is commonly used in analytical techniques, such as chromatography and spectrophotometry, to monitor and quantify the presence of certain compounds in samples.
Automatically generated - may contain errors
Lab products found in correlation
Fastlab, by GE Healthcare (1 mentions)
S propranolol hydrochloride, by Merck Group (1 mentions)
Pindolol, by Merck Group (1 mentions)
Cl316 243, by Bio-Techne (1 mentions)
Fenoterol, by Merck Group (1 mentions)
Forskolin, by Merck Group (1 mentions)
Probenecid, by Merck Group (1 mentions)
Verapamil, by Merck Group (1 mentions)
Epinephrine, by Merck Group (1 mentions)
2 protocols using carazolol
1
Radiolabeled PET Tracers and Ligands Synthesis
2
Cellular Uptake and Transport Assay
Check if the same lab product or an alternative is used in the 5 most similar protocols
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Epinephrine, fenoterol, forskolin, methoxamine, phentolamine, carazolol, 551, -2-propenyl]amino]ethyl]-5-isoquinolinesulfonamide (H89), probenecid and verapamil were provided by Sigma-Aldrich (Saint-Quentin Fallavier, France).
8-bromo-cAMP (8-Br-cAMP), N 6 -benzoyladenosine-cAMP (6-Bnz-cAMP) and 8-(4chlorophenylthio)-2′-O-methyl-cAMP (8-pCPT-cAMP), used under its cell-permeable acetoxymethyl ester form, were from Tocris (Bristol, United Kingdom), whereas Gö 6983 was from Calbiochem (La Jolla, CA, USA). Germany) . Rabbit polyclonal antibodies raised against organic anion transporter polypeptide (OATP) 1B1 (SLCO1B1) or OATP2B1 (SLCO2B1) have been previously described (Huber et al., 2007) . All other compounds and reagents were commercial products of the highest purity available.
8-bromo-cAMP (8-Br-cAMP), N 6 -benzoyladenosine-cAMP (6-Bnz-cAMP) and 8-(4chlorophenylthio)-2′-O-methyl-cAMP (8-pCPT-cAMP), used under its cell-permeable acetoxymethyl ester form, were from Tocris (Bristol, United Kingdom), whereas Gö 6983 was from Calbiochem (La Jolla, CA, USA). Germany) . Rabbit polyclonal antibodies raised against organic anion transporter polypeptide (OATP) 1B1 (SLCO1B1) or OATP2B1 (SLCO2B1) have been previously described (Huber et al., 2007) . All other compounds and reagents were commercial products of the highest purity available.
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