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P methyl bha mbha resin

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P-methyl-BHA (MBHA) resin is a solid-phase synthesis resin used in organic chemistry. It is designed for the preparation of peptides and other organic compounds. The resin consists of a polystyrene-divinylbenzene copolymer matrix with pendant 4-methylbenzhydrylamine (MBHA) groups, which serve as the functional groups for chemical reactions.

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Lab products found in correlation

Triisopropylsilane, by Merck Group (2 mentions) N dimethylformamide, by Merck Group (2 mentions) P cresol, by Merck Group (2 mentions) Tris 2 carboxyethyl phosphine tcep, by Merck Group (1 mentions) Acetonitrile, by Merck Group (1 mentions) Dspe peg2000, by Xi’an Ruixi (1 mentions) Guanidine hydrochloride guhcl, by Merck Group (1 mentions) Hplc grade acetonitrile, by Merck Group (1 mentions) Methanol, by Merck Group (1 mentions) N n dimethylformamide dmf dichloromethane, by Merck Group (1 mentions) 4 mercaptophenylacetic acid, by Merck Group (1 mentions) Glutathione (gsh), by Merck Group (1 mentions) Dichloromethane, by Merck Group (1 mentions) Ultra pure guanidine hydrochloride, by Merck Group (1 mentions) N diisopropylethylamine, by Merck Group (1 mentions)

3 protocols using p methyl bha mbha resin

1

Synthesis of Lipid-Peptide Conjugates

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Soybean lecithin, DSPE-PEG2000 and DSPE-PEG2000-Maleimide was purchased from Xi’an Ruixi Biological Technology Co., Ltd, oridonin from MCE®, and DCM from Sigma-Aldrich®. TLR2 pep-Cys was chemically synthesized on solid phase. P-methyl-BHA (MBHA) resin was purchased from Applied Biosystems®, Boc protected amino acids were purchased from Peptides Institute®. Other reagents for peptide synthesis and cleavage, including GSH, dichloromethane (DCM), N, N-dimethylformamide (DMF), acetonitrile, Tris-(2-carboxyethyl) phosphine (TCEP), triisopropylsilane (TIPS), N, N-diisopropylethylamine (DIEA), p-cresol and guanidine hydrochloride (GuHCl) were purchased from Sigma-Aldrich®. Trifluoroacetic acid (TFA) was purchased from Halocarbon®.
Liu Y., Wang X., Feng H., Li X., Yang R., Zhang M., Du Y., Liu R., Luo M., Li Z., Liu B., Wang J., Wang W., An F., Niu F, & He P. (2024). Glutathione-depleting Liposome Adjuvant for Augmenting the Efficacy of a Glutathione Covalent Inhibitor Oridonin for Acute Myeloid Leukemia Therapy. Journal of Nanobiotechnology, 22, 299.
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2

Solid-Phase Peptide Synthesis of Natural Compounds

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Boc-amino acids were purchased from Peptides
Institute. Boc-Leu–OCH2–PAM resin and p-methyl-BHA (MBHA) resin were purchased from Applied Biosystems
(Foster City, CA). N,N-Dimethylformamide
(DMF), dichloromethane (DCM), N,N-diisopropylethylamine (DIEA), dimethyl sulfoxide (DMSO), methanol,
4-mercaptophenylacetic acid (MPAA), tris(2-carboxyethyl) phosphine
(TCEP), p-cresol, and HPLC grade acetonitrile were
purchased from Sigma-Aldrich (St. Louis, MO). Hydrogen fluoride (HF)
was purchased from APK (Shanghai, China). Trifluoroacetic acid (TFA)
was purchased from HaloCarbon (River Edge, NJ). Tanshinone IIA, dihydrotanshinone
1, tanshinone 1, and cryptotanshinone were purchased from Nature Standard
(Shanghai, China). Ammonium glycyrrhizinate, astragaloside A, baicalein,
curculigoside, ginsenoside Rb, ginsenoside Re, osthol, panaxadiol,
quercetin, and dihydrotanshinone were provided as generous gifts by
Dr. Sha Liao of Northwestern University of China. All natural herbal
compounds were prepared in DMSO (5–10 mM) and stored in the
dark at room temperature for no more than 1 month.
Feng C., Huang Y., He W., Cheng X., Liu H., Huang Y., Ma B., Zhang W., Liao C., Wu W., Shao Y., Xu D., Su Z, & Lu W. (2019). Tanshinones: First-in-Class Inhibitors of the Biogenesis of the Type 3 Secretion System Needle of Pseudomonas aeruginosa for Antibiotic Therapy. ACS Central Science, 5(7), 1278-1288.
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3

Peptide Synthesis and Purification

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Boc amino acids were obtained from Peptides Institute; p‐methyl‐BHA (MBHA) resin was purchased from Applied Biosystems; Tris‐(2‐carboxyethyl) phosphine (TCEP), glutathione (GSH), dichloromethane (DCM), N, N‐dimethylformamide (DMF), acetonitrile, triisopropylsilane (TIPS), N, N‐diisopropylethylamine (DIEA), p‐cresol and ultrapure guanidine hydrochloride (GuHCl) were obtained from Sigma‐Aldrich; and trifluoroacetic acid (TFA) was purchased from Halocarbon.
Ma B., Fan Y., Zhang D., Wei Y., Jian Y., Liu D., Wang Z., Gao Y., Ma J., Chen Y., Xu S, & Li L. (2022). De Novo Design of an Androgen Receptor DNA Binding Domain‐Targeted peptide PROTAC for Prostate Cancer Therapy. Advanced Science, 9(28), 2201859.
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