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2 protocols using pseudoephedrine

1

Quantitative Analysis of Fentanyl Analogs

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Legally exempt, certified reference standards (fentanyl, carfentanil oxalate, acrylfentanyl, 4‐fluoro‐isobutyryl fentanyl (FIBF), furanylfentanyl, heroin, acetaminophen, chlorpheniramine maleate, and pseudoephedrine) and isotopically labeled internal standards (fentanyld5, carfentanil‐d5 oxalate, acetaminophend4, chlorpheniramine‐d6 maleate, and pseudoephedrined3 HCl) were purchased from Cerilliant Corporation (Round Rock, TX, USA). Caffeine and Caffeined3 were purchased from Sigma‐Aldrich (St. Louis, MO, USA). The structures of all drugs used in this study are given in Figure S1. HPLC grade methanol was obtained from VWR International (Mississauga, ON, Canada). ACS grade formic acid was acquired from GFS Chemicals (Columbus, OH, USA). Deionized (DI) water was prepared using a water purification system (18.4 MΩ·cm Facility Scale Reverse Osmosis/Ion Exchange Water Purification System; Applied Membranes Inc, Vista, CA, USA). All standards were prepared gravimetrically, with w/w concentrations represented as ng of analyte per g of total mass.
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2

Comprehensive Synthetic Cathinone Analysis

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The stock standard solutions of amphetamine (A), methamphetamine (MA), phenylpropanolamine (PHPR), ephedrine, pseudoephedrine (PSE), 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxy-N-ethylamphetamine (MDEA), phentermine (PHRM), methylphenidate (MPHD), bupropion, hydroxybupropion, methcathinone (ephedrone), methedrone (PMMC), mephedrone (4-MMC), methylone (MDMC), ethylone (MDEC), 3,4-methylenedioxypyrovalerone (MDPV), and alpha-pyrrolidinopentiophenone (alpha-PVP) at a concentration of 1.0 mg mL -1 for each analyte in methanol were purchased from Cerilliant (Round Rock, Texas, USA). Stock standard solutions of the internal standards (ISTDs), namely amphetamine-d11, methamphetamine-d11, ephedrine-d3, pseudoephedrine-d3, norpseudoephedrine-d3, MDA-d5, MDMA-d5, MDEA-d5, phentermine-d5, methylphenidate-d9, bupropion-d9, hydroxybupropion-d6, mephedrone-d3, and methylone-d3, were also purchased from Cerilliant (Round Rock, TX, USA) at a concentration of 100 µg mL -1 in methanol.
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