Labrasol

Manufactured by Merck Group

Sourced in United States

Labrasol is a non-ionic surfactant that is used as a solubilizing and emulsifying agent in the formulation of various pharmaceutical and cosmetic products. It is a polyethoxylated mono- and diglyceride of caprylic/capric acid. Labrasol is designed to improve the solubility and bioavailability of poorly water-soluble drugs.

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Lab products found in correlation

Tween 80, by Merck Group (1 mentions) Span 80, by Merck Group (1 mentions) Compritol 888 ato, by Merck Group (1 mentions) Poloxamer 188, by Merck Group (1 mentions) Capryol 90, by Merck Group (1 mentions) Coq10, by Merck Group (1 mentions) Analytical grade chemicals, by Merck Group (1 mentions) Chloroform, by Merck Group (1 mentions) Lps from escherichia coli 0111 b4, by Merck Group (1 mentions) Dicetyl phosphate, by Merck Group (1 mentions) Bromelain, by Merck Group (1 mentions)

3 protocols using labrasol

Pioglitazone Hydrochloride Formulation Development

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Pioglitazone hydrochloride (PGZ) drug was received as a gift sample from Xellia Pharmaceuticals. Methanol, Tween 80, poloxamer 188, Span 80, Compritol^® 888 ATO, and Labrasol^® were procured from Sigma-Aldrich (St. Louis, MO, United States). Analytical-grade quality was assured for all chemicals.

Ilyas U., Asif M., Wang M., Altaf R., Zafar H., Faran Ashraf Baig M.M., Paiva-Santos A.C, & Abbas M. (2022). Nanostructured Lipid Carrier-Based Delivery of Pioglitazone for Treatment of Type 2 Diabetes. Frontiers in Pharmacology, 13, 934156.

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Coenzyme Q10 and Rosuvastatin Protocol

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CoQ10 was obtained from Sigma-Aldrich (St. Louis, MO, United States), whereas rosuvastatin (RUS) and CoQ10 solubilizing agents that include [Labrasol, Labrafil (M1944 CS), and Capryol 90] were generously gifted from the Global Napi for Pharmaceutical industry (Cairo, Egypt) and Gattefosse (Lyon, France), respectively.

Abd El-Aal S.A., Abd El-Fattah M.A, & El-Abhar H.S. (2017). CoQ10 Augments Rosuvastatin Neuroprotective Effect in a Model of Global Ischemia via Inhibition of NF-κB/JNK3/Bax and Activation of Akt/FOXO3A/Bim Cues. Frontiers in Pharmacology, 8, 735.

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Anti-inflammatory Activity Assessment

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All the chemicals used in this study were purchased from Sigma Aldrich and Merck, unless otherwise noted. The Span (40, 60, 80) , Labrasol, dicetyl phosphate, and chloroform used were also purchased from Sigma Aldrich. Bromelain was purchased from Merck, while the LPS from Escherichia coli (0111:B4) was purchased from Sigma Aldrich. The TNF-α kit (Catalogue Number RAB0476) and the IL-6 kit (Catalogue Number RAB0307) were purchased from Sigma Aldrich (USA). The analytical grade chemicals used in this study were purchased from Sigma Aldrich.
The mice were purchased from Universiti Kebangsaan Malaysia.

Chermahini S.H. (2020). Niosome Encapsulated Bromelain Reduced IL-6 and TNF-α in LPS Induced in Mice. Archives in Neurology & Neuroscience, 6(3).

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