All participants were scanned on the same MRI and PET cameras, a Philips (Best, the Netherlands) Achieva 3.0T scanner and a Discovery RX VCT 64 PET‐CT device (GE Healthcare, Chicago, IL), respectively. A high‐resolution T1‐weighted anatomical volume was acquired using a 3‐dimensional (3D) fast‐field echo sequence (sagittal, repetition time = 20 milliseconds, echo time = 4.6 milliseconds, flip angle = 10°, 180 slices with no gap, slice thickness = 1mm, field of view = 256 × 256mm2, in‐plane resolution = 1 × 1mm2). Resting‐state functional volumes were obtained using an interleaved 2D T2*SENSitivity Encoding (SENSE) echo planar imaging (EPI) sequence designed to reduce geometric distortions using parallel imaging, short echo time, and small voxels (axial, SENSE = 2, repetition time = 2,382 milliseconds, echo time = 30 milliseconds, flip angle = 80°, 42 slices with no gap, slice thickness = 2.8mm, field of view = 224 × 224mm2, in plane resolution = 2.8 × 2.8mm2, 280 volumes, acquisition time = 11.5 minutes).
Discovery rx vct 64
Manufactured by GE Healthcare
Sourced in United States, France
The Discovery RX VCT 64 is a computed tomography (CT) imaging system manufactured by GE Healthcare. It is a 64-slice CT scanner that can capture high-resolution images of the body. The device is designed to support a range of clinical applications, including diagnostic imaging and image-guided procedures.
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4 protocols using discovery rx vct 64
1
Multimodal Neuroimaging Protocol for Resting-State fMRI
2
Florbetapir PET Imaging of Amyloid Deposition
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The PET scans with florbetapir ([18F]AV45) were acquired on a Discovery RX VCT 64 PET-CT scanner (General Electric Healthcare, United States) at the Cyceron Center (Caen, France) with a resolution of 3.76 × 3.76 × 4.9 mm3 (field of view = 157 mm) to measure Aβ deposition within the brain. Approximately 4 MBq/kg of AV45 were injected intravenously and 47 planes with a voxel size of 1.95 × 1.95 × 3.2 mm3 were obtained at 50–70 min post-injection. A transmission scan was performed for attenuation correction before the PET acquisition.
The AV45-PET images were linearly co-registered to the corresponding T1-weighted MRI image and warped onto the MNI template, using the deformation matrices derived from the “Segment” procedure (described under MRI analyses). Standardized uptake value ratios (SUVR) were computed by dividing the cerebral tracer uptake by the tracer uptake of the whole cerebellum serving as a reference region. Mean SUVR values were extracted from brain regions typically affected in AD, using a modality-specific AD meta-signature mask, including all neocortical regions, but excluding para-hippocampi, pre- and post-central gyri, and occipital cortices (Besson et al., 2015 (link)). For the current analyses, the first available timepoint with a valid measurement of Aβ-PET SUVR was selected: n = 77 at T1 and n = 18 at T2.
The AV45-PET images were linearly co-registered to the corresponding T1-weighted MRI image and warped onto the MNI template, using the deformation matrices derived from the “Segment” procedure (described under MRI analyses). Standardized uptake value ratios (SUVR) were computed by dividing the cerebral tracer uptake by the tracer uptake of the whole cerebellum serving as a reference region. Mean SUVR values were extracted from brain regions typically affected in AD, using a modality-specific AD meta-signature mask, including all neocortical regions, but excluding para-hippocampi, pre- and post-central gyri, and occipital cortices (Besson et al., 2015 (link)). For the current analyses, the first available timepoint with a valid measurement of Aβ-PET SUVR was selected: n = 77 at T1 and n = 18 at T2.
3
Neuroimaging Examination Standardization
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All neuroimaging examinations were performed at the Cyceron Center (Caen, France) on the same MRI and PET cameras (Philips Achieva 3T and a GE Healthcare Discovery RX VCT 64 PET-CT scanners, respectively).
4
Multi-modal Neuroimaging of Brain Lesions
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All participants underwent a brain MRI scan using a 1.5 T imager at one center (Tours) and 3 T imagers at the other two centers (Caen and Toulouse). T2-weighted images from each subject were used to investigate brain lesions. 3D T1-weighted volume (SPGR sequence, TE/TR/TI = 3.5/10.76/600 ms, bandwidth = 97 Hz/px, flip angle = 10°, and voxel size: 1.1 × 1.1 × 1.2 mm3) was used for volumetric analysis.
PET-CT scans with 18F-FDG were performed on a hybrid tomograph, operating in 3D detection mode (Dual Gemini, Philips Medical Systems, Discovery RX VCT 64, General Electric, and Biograph 6 TruePoint HiRez, Siemens Medical Solutions, resp., in Tours, Caen, and Toulouse). Capillary glycaemia was checked prior to 18F-FDG PET. PET scans were acquired 30 minutes after an injection of 185 MBq of 18F-FDG (mean value). A dynamic PET acquisition was performed, lasting 30 minutes with six 5 min frames. All PET sinograms were reconstructed by adapting the parameters to those of the tomograph with the lowest spatial resolution (Dual Gemini), with corrections for randomness, scatter, photon attenuation, and decay, which produced images with an isotropic voxel of 2 × 2 × 2 mm3. The six frames were averaged into a single image.
PET-CT scans with 18F-FDG were performed on a hybrid tomograph, operating in 3D detection mode (Dual Gemini, Philips Medical Systems, Discovery RX VCT 64, General Electric, and Biograph 6 TruePoint HiRez, Siemens Medical Solutions, resp., in Tours, Caen, and Toulouse). Capillary glycaemia was checked prior to 18F-FDG PET. PET scans were acquired 30 minutes after an injection of 185 MBq of 18F-FDG (mean value). A dynamic PET acquisition was performed, lasting 30 minutes with six 5 min frames. All PET sinograms were reconstructed by adapting the parameters to those of the tomograph with the lowest spatial resolution (Dual Gemini), with corrections for randomness, scatter, photon attenuation, and decay, which produced images with an isotropic voxel of 2 × 2 × 2 mm3. The six frames were averaged into a single image.
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