The fluid dynamics on the iBAC were simulated using COMSOL Multiphysics to verify and optimize the swing frequency and swing angle for desired shear stress. Finally, the relative stable fluid flow rate (180 μL/min) and shear force (0.22 dyne/cm2) could be achieved when the swing angle was 30 degrees and the swing frequency was 1 circle/min (
Multiphysics simulation
COMSOL Multiphysics is a simulation software that allows users to model and analyze multiphysics problems. It provides a unified environment for defining geometry, material properties, and boundary conditions, as well as obtaining numerical solutions and visualizing results.
Lab products found in correlation
2 protocols using multiphysics simulation
Development of Kidney Microphysiological System
The fluid dynamics on the iBAC were simulated using COMSOL Multiphysics to verify and optimize the swing frequency and swing angle for desired shear stress. Finally, the relative stable fluid flow rate (180 μL/min) and shear force (0.22 dyne/cm2) could be achieved when the swing angle was 30 degrees and the swing frequency was 1 circle/min (
Computational Fluid Dynamics Analysis of Blood Flow
Where P, μ and ρ are the pressure, dynamic viscosity,y and density of the fluid respectively. u is the velocity vector, t is time and g is the gravitational acceleration, and I is the identity matrix.
Blood is a non-Newtonian fluid, but it is represented in our simulations as a Newtonian fluid. The corresponding dynamic viscosity μ in Eq.
And
with
Where m, n and are the fluid consistency coefficient, flow behaviour index, and lower shear rate limit respectively.
To verify the numerical method, each model was implemented 3 times under equal simulated conditions and the differences between the results obtained were examined. In the next step, we increased the input speed to the chip at a constant rate in 4 steps and evaluated the results. If the trend of the results is proportional to the rate of acceleration rate, the accuracy of the simulations performed is supported.
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