Cobas t511

Manufactured by Roche

Sourced in United Kingdom

The Cobas t511 is a fully automated laboratory instrument designed for the measurement of coagulation parameters. It performs clotting, chromogenic, and immunologic coagulation tests. The Cobas t511 is capable of handling a wide range of sample types and provides reliable and consistent results.

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4 protocols using cobas t511

Coagulation Profiles in COVID-19 Severity

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The coagulation monitoring has done using the autoanalyzer Cobas t511 (Roche). The coagulation profile includes the determination of PT, aPTT, fibrinogen, d‐dimer, and the count of platelets. The laboratory results were obtained from the Sistema de Gestión del Laboratorio of the hospital where all clinical analysis reports are stored.
Data collection was conducted during the second wave of COVID‐19 in Peru from January to April 2021. Data analysis was initially descriptive to estimate the frequencies of the continuous variables and the mean and the standard deviation of the categorical variables. We used paired T‐test and ANOVA one‐way with Bonferroni post hoc test to determine the differences of the values of the coagulation profile and the severity of the COVID‐19. The analysis of association between the alterations of coagulation markers with the parameters of oxygen function and lung damage have been taken with the Spearman's test and Kendal−Tau b considering the p < 0.05 and the confidence interval of 95% as the significant. The data analysis has done in SPSS v24.0.

Moya‐Salazar J., Cóndor L.Y., Zuñiga N., Jaime‐Quispe A., Moya‐Salazar B., Chicoma‐Flores K., Cañari B, & Contreras‐Pulache H. (2023). Alterations in the coagulation markers did not show differences with the severity of COVID‐19 in Peruvian patients: A cross‐sectional single‐center study. Health Science Reports, 6(3), e1105.

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Comprehensive Hematological and Inflammatory Profiling

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The following parameters were measured using EDTA anti-coagulated whole blood:
Neutrophil granulocytes (*10⁹/L), RBCs (*10¹²/L), thrombocytes (*10⁹/L), relative numbers of eosinophils (%), leukocytes (*10⁹/L), RDW (%), Hct (%), Hb concentration (g/dL), MCH (pg), MCHC (g/dL), MCV (fl), C-reactive protein (CRP) (mg/L), ferritin (µg/L), D-dimers (mg/IU), and fibrinogen concentration (g/L). Parameters were determined and analyzed by clinical standards using the Sysmex XE-5000 analyzer (Sysmex, Hamburg, Germany) system (based on resistance measurement principle (impedance measurement, Coulter measurement principle), photometric measurement, differentiation in a flow cell by means of laser via VCSn technology (volume, conductivity, scatter)) as well as ECLIA (Roche Immunoassay Analyzer Cobas 8000, Cobas t 711 and Cobas t 511, Basel, Switzerland) and ELISA measurements.

Bizjak D.A., John L., Matits L., Uhl A., Schulz S.V., Schellenberg J., Peifer J., Bloch W., Weiß M., Grüner B., Bracht H., Steinacker J.M, & Grau M. (2022). SARS-CoV-2 Altered Hemorheological and Hematological Parameters during One-Month Observation Period in Critically Ill COVID-19 Patients. International Journal of Molecular Sciences, 23(23), 15332.

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Evaluation of COVID-19 in Pregnant Women

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The criterion for performing PCR was the identification of suggestive symptoms in the evaluation of emergency services, and blood samples were taken upon admission without taking into account the days of evolution of the symptoms. Medical data such as age, gestational age, pregestational body mass index (pBMI (kg/m²)), the status of chronic hypertension, pre-gestational diabetes, chronic renal disease, mean arterial pressure (MAP), oxygen saturation (SpO2), preeclampsia, threatened preterm labor, fetal growth restriction, stillbirth, pneumonia, viral sepsis, and mortality were collected from medical records. Rutinary blood samples were obtained at hospital admission. Troponin T and D-dimer serum levels were measured by an automated analyzer (Cobas-t511, Roche^®, Mexico City, Mexico), whereas C-reactive protein serum levels were measured using an automated analyzer (Cobas-501, Roche^®, Mexico City, Mexico) according to the manufacturer’s instructions.

Torres-Torres J., Martinez-Portilla R.J., Espino y Sosa S., Solis-Paredes J.M., Hernández-Pacheco J.A., Mateu-Rogell P., Cravioto-Sapien A., Zamora-Madrazo A., Estrada-Gutierrez G., Nares-Torices M.A., Becerra-Navarro N.P., Medina-Jimenez V., Villafan-Bernal J.R., Rojas-Zepeda L., Loya-Diaz D.H, & Casillas-Barrera M. (2022). Maternal Death by COVID-19 Associated with Elevated Troponin T Levels. Viruses, 14(2), 271.

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Coagulation Assays Validation Across Analyzers

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The study was conducted between January 2017 and April 2017 at three European teaching hospitals (Inselspital University Hospital, Bern, Switzerland; Erasmus University Medical Center, Rotterdam, The Netherlands; Sheffield Haemostasis and Thrombosis Centre, UK). Anonymized residual sodium citrate (3.2%/0.109 mol/l) plasma samples were evaluated on the cobas t 711 (high-throughput; max. 390 tests/h: all three centers) and cobas t 511 (mid-throughput; max. 195 tests/h: UK center only) analyzers, using a number of coagulation assays (aPTT, aPTT Lupus, aPTT Screen, AT, d-Dimer, Fibrinogen, PT-derived Fibrinogen, PT Owren, PT Rec and TT; Roche Diagnostics, Switzerland) described in detail previously [27 (link),29 (link)]. All assays and analyzers were used according to manufacturers’ instructions.
Independent ethics committee approval was obtained before study initiation and the study was performed according to the principles of the Declaration of Helsinki and International Council for Harmonisation Good Clinical Practice guidelines.

Kitchen S., de Maat M., Nagler M., Jones R., Lowe A., Burden J., Groneberg K, & Rozsnyai G. (2020). System performance evaluation of the cobas t 711 and cobas t 511 coagulation analyzers in routine laboratory settings. Blood Coagulation & Fibrinolysis, 31(7), 459-468.

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