In house purification system

Manufactured by Merck Group

Sourced in United States

The In-house purification system is a laboratory equipment designed for the purification of various substances. It provides a reliable and efficient method for the separation and isolation of target compounds from complex mixtures. The core function of the system is to facilitate the purification process, ensuring the obtained samples meet the required purity standards for further analysis and research applications.

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Lab products found in correlation

Formic acid, by Biosolve (3 mentions) Propionic anhydride, by Merck Group (2 mentions) Ammonium acetate, by Biosolve (2 mentions) Ammonium hydroxide solution, by Merck Group (2 mentions) Hydrochloric acid (hcl), by Merck Group (2 mentions) Methanol, by Biosolve (2 mentions) Dipotassium hydrogen phosphate, by Merck Group (2 mentions) Acetonitrile lc ms grade, by Biosolve (2 mentions) Isopropanol, by Biosolve (2 mentions) Dopamine hcl, by Merck Group (1 mentions) Dl metanephrine hcl, by Merck Group (1 mentions) Dl normetanephrine hcl, by Merck Group (1 mentions) L dopa d3, by Merck Group (1 mentions) Stable deuterated isotopesfor dopamine d4 hcl, by CDN Isotopes (1 mentions) Norepinephrine d6 hcl, by CDN Isotopes (1 mentions) Epinephrine d3, by CDN Isotopes (1 mentions) 3 methoxytyramine d4 hcl, by Cambridge Isotopes (1 mentions) Dl metanephrine d3 hcl, by Cambridge Isotopes (1 mentions) 3 methoxytyramine, by Merck Group (1 mentions) L dopa, by Merck Group (1 mentions)

3 protocols using in house purification system

Quantification of Catecholamines and Metabolites

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LC-MS grade acetonitrile, isopropanol, methanol,
formic acid, and ammonium acetate were purchased from Biosolve BV
(Valkenswaard, The Netherlands). Glutathione (reduced), ascorbic acid,
dipotassium hydrogen phosphate, pyridine, and hydrochloric acid (32%)
were from Merck Millipore (Darmstadt, Germany). Ammonium hydroxide
solution (28–30%), propionic anhydride, K₂EDTA dihydrate, l-DOPA, dopamine-HCl, nor epinephrine, epinephrine, 3-methoxytyramine, dl-metanephrine-HCl, dl-normetanephrine-HCl, and l-DOPA-d₃, all of analytical purity,
were purchased from Sigma-Aldrich (MI, USA). Stable deuterated isotopes
for dopamine-d₄-HCl, nor epinephrine-d₆-HCl, and epinephrine-d₃ were from CDN Isotopes (Pointe-Claire, Canada), 3-methoxytyramine-d₄-HCl and dl-metanephrine-d₃-HCl from Cambridge Isotopes (MA, USA), and dl-normetanephrine-d₃-HCl from Medical
Isotopes (NH, USA). Ultrapure water was produced using an in-house
purification system (Merck Millipore, MA, USA).

van Faassen M., Bischoff R., Eijkelenkamp K., de Jong W.H., van der Ley C.P, & Kema I.P. (2020). In Matrix Derivatization Combined with LC-MS/MS Results in Ultrasensitive Quantification of Plasma Free Metanephrines and Catecholamines. Analytical Chemistry, 92(13), 9072-9078.

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Quantification of 6-Sulfatoxymelatonin in Biological Samples

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We obtained ULC-MS-grade methanol, acetonitrile, isopropanol, ammonium acetate, and formic acid from Biosolve BV (Valkenswaard, The Netherlands). Phosphate buffered saline (PBS; 0.01 M Na 2 HPO 4 , 1.8 mM KH 2 PO 4 , 0.138 M NaCl, 27 mM KCl, pH 7.4) was prepared by the Department of Pharmacy of the UMCG. 6-sulfatoxymelatonin sodium salt was purchased from Toronto Research Chemicals Inc. (Toronto, Canada), and the D 4 -labeled internal standard (IS) for 6-sulfatoxymelatonin was purchased from CacheSyn Inc. (Mississauga, Canada). Ultrapure water was produced using an in-house purification system (Merck Millipore, MA, USA).

van Faassen M., van der Veen A., van Ockenburg S., de Jong H., de Vries E.G.E, & Kema I.P. (2020). Mass spectrometric quantification of urinary 6-sulfatoxymelatonin: age-dependent excretion and biological variation. Clinical chemistry and laboratory medicine, 59(1).

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Quantitative LC-MS Analysis of Neurotransmitters

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LC-MS-grade acetonitrile, isopropanol, methanol, formic acid, and ammonium acetate were purchased from Biosolve. Ascorbic acid, dipotassium hydrogen phosphate, acetic acid (99%), and hydrochloric acid (32%) were obtained from Merck Millipore. Ammonium hydroxide solution (28%-30%), propionic anhydride, dipotassium EDTA dihydrate, glutathione (reduced), tryp- tophan, 5-HTP, serotonin, and 5-HIAA, all of analytical purity, were purchased from Sigma Aldrich. Ultrapure water was produced with an in-house purification system (Merck Millipore). Stable deuterated isotopes for tryptophan-d5, serotonin-d4 creatinine sulfate, and 5-HIAA-d2 were purchased from CDN Isotopes; 5-HTP-d4, from Toronto Research Chemicals.

van Faassen M., Bouma G., de Hosson L.D., Peters M.A.M., Kats-Ugurlu G., de Vries E.G.E., Walenkamp A.M.E, & Kema I.P. (2019). Quantitative Profiling of Platelet-Rich Plasma Indole Markers by Direct-Matrix Derivatization Combined with LC-MS/MS in Patients with Neuroendocrine Tumors. Clinical chemistry, 65(11).

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