Recombinant human interferon gamma ifnγ

Manufactured by BioLegend

Recombinant human interferon gamma (IFNγ) is a cytokine produced by various immune cells. It plays a key role in the activation of the immune system and has been widely used in research and clinical applications.

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Lab products found in correlation

Cd137 41bb, by BioLegend (2 mentions) Pd l1, by BioLegend (1 mentions) Cd8 clone yts 169, by BioXCell (1 mentions) H 2kb h 2db, by BioLegend (1 mentions) Cd11b, by BioLegend (1 mentions) Hsp90, by Abcam (1 mentions)

2 protocols using recombinant human interferon gamma ifnγ

Immunological Profiling of Tumor Microenvironment

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Recombinant human interferon gamma (IFNγ; catalog no. 570206) and antibodies to human HLA-ABC (catalog no. 311404) and PD-L1 (catalog no. 329706) were obtained from Biolegend. The antibody for intracellular calreticulin was obtained from R&D Systems (catalog no. IC3898R), and the antibodies to TAP1, TAP2, LMP2, ERp57 were obtained from Abcam (catalog numbers ab83817, ab180611, ab190350, and ab13506, respectively). Pharmaceutical grade cisplatin was obtained from the veterinary pharmacy at NIH. Antibodies for in vivo mouse treatments specific for PD-L1 (clone 10F.9G2), PD-1 (clone RMP1-14), NK1.1 (clone PK136) and CD8 (clone YTS 169.4) were from BioXCell. Fluorescent-conjugated flow cytometry antibodies for mouse tumor experiments were obtained from eBioscience (CD137/41BB, catalog no. 46-1371-80) or Biolegend: CD8 (catalog no. 100712), CD45.2 (catalog no. 109806), CD80 (catalog no. 104721), CD11b (catalog no. 101211), CD11c (catalog no. 117307), CD107a (catalog no. 121619), Ly6G (catalog no. 127623), Ly6C (catalog no. 128017), and H-2Kb/H-2Db (catalog no. 114611).

Tran L., Allen C.T., Xiao R., Moore E., Davis R., Park S.J., Spielbauer K., Van Waes C, & Schmitt N.C. (2017). Cisplatin Alters Antitumor Immunity and Synergizes with PD-1/PD-L1 Inhibition in Head and Neck Squamous Cell Carcinoma. Cancer immunology research, 5(12), 1141-1151.

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Comprehensive Immune Checkpoint Modulatory Protocol

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Recombinant human interferon-gamma (IFN-γ) and antibodies to human MHC class I and PD-L1 were obtained from Biolegend. Antibodies to calreticulin (CRT), HSP70 and HSP90 were obtained from Abcam. The anti-PD-1 antibody for in vivo mouse treatments (clone RMP1–14) was from BioXCell. Fluorescent-conjugated flow cytometry antibodies for mouse tumor experiments were obtained from eBioscience (CD137/41BB) or Biolegend (CD8, CD45, CD80, CD11b, CD11c, CD107a, Ly6G, Ly6C, H-2Kb/H-2Db). Pharmaceutical grade chemotherapy was obtained from the veterinary pharmacy at NIH.

Park S.J., Ye W., Xiao R., Silvin C., Padget M., Hodge J.W., Waes C.V, & Schmitt N.C. (2019). Cisplatin and Oxaliplatin Induce Similar Immunogenic Changes in Preclinical Models of Head and Neck Cancer. Oral oncology, 95, 127-135.

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