3.0 tesla signal scanner

All the patients were in the “ON” state before and during scanning. Image data were acquired using a Siemens 3.0-Tesla signal scanner (Siemens, Verio, Germany). Subjects were instructed to stay awake and close their eyes, and to try not to think of anything. Functional imaging data were collected transversely by using a gradient-recalled echo-planar imaging (GRE-EPI) pulse sequence with the following settings: TR/TE = 200 ms/30 ms, flip angle = 90°, matrix = 64 × 64, FOV = 220 mm × 220 mm, thickness/gap = 3.5 mm/0.6 mm, in-plane resolution = 3.4 mm × 3.4 mm, slices = 31. For each subject, a total of 140 volumes were obtained, resulting in a total scan time of 280 s. High resolution anatomical images were acquired using a T1 fluid attenuated inversion recovery (FLAIR) sequence (TR/TE = 2530 ms/3.34 ms, flip angle = 7°, matrix = 256 × 192, FOV = 256 mm × 256 mm, slice thickness/gap = 1.33 mm/0.5 mm, 128 slices covered the whole brain).

Image data were acquired using a Siemens 3.0-Tesla signal scanner (Siemens, Verio, Germany) in the department of radiology within Nanjing Brain Hospital. Functional imaging data were collected transversely by using a gradient-recalled echo-planar imaging (GRE-EPI) pulse sequence with the following configurations: TR/TE = 200 ms/30 ms, flip angle = 90°, matrix = 64 × 64, FOV = 220 × 220 mm, thickness/gap = 3.5/0.6 mm, in-plane resolution = 3.4 × 3.4 mm, slices = 31. For each subject, a total of 140 volumes were obtained, resulting in a total scan time of 280 s. High resolution anatomical images were acquired using a T1 fluid attenuated inversion recovery (FLAIR) sequence (TR/TE = 2530/3.34 ms, flip angle = 7°, matrix = 256 × 192, FOV = 256 × 256 mm, slice thickness/gap = 1.33/0.5 mm, 128 slices covered the whole brain). The subjects were instructed to keep their eyes closed, relax their minds and remain as motionless as possible during the data acquisition. Rubber earplugs were used to reduce noise, and foam cushioning was used to fix the head to reduce motion artifacts. The MR images were retrieved from the archive by two experienced neuroradiologists (QH and XW).

All the patients were in the “on” state before and during MRI. MRI data were acquired using a Siemens 3.0-Tesla signal scanner (Siemens, Verio, Germany). Participants were instructed to remain as still as possible, close their eyes, remain awake and not to think of anything. Axial anatomical images were acquired using a T1-FLAIR sequence (TR/TE = 2530ms/3.34ms, flip angle = 7°, matrix = 256×192, FOV = 256mm×256mm, slice thickness/gap = 1.33 mm/0.5mm, 128 slices covered the whole brain) for image registration and functional localization. Functional images were subsequently collected in the same slice orientation with a gradient-recalled echo-planar imaging (GRE-EPI) pulse sequence (TR/TE = 2000ms/30 ms, flip angle = 90°, matrix = 64×64, FOV = 220 mm×220 mm, thickness/gap = 3.5 mm/0.6mm, in-plane resolution = 3.4 mm×3.4 mm, slices numbers = 31). 140 volumes were obtained in this acquisition sequence and each functional resting-state session lasted 280s.