Patients in the RRG were given the NSAIDs COX-2 inhibitor Celecoxib Capsule (200 mg, Pfizer, Inc., New York, NY, USA) orally bid. from the second day before surgery. Intravenous NSAIDs COX-2 inhibitor was administered Q12H for the first 3 days after the operation with Parichib Sodium for injection (Dynastat, 40 mg, Pfizer Inc.), followed by oral administration of Celecoxib Capsule on the fourth day (200 mg, bid).
Celecoxib capsule
Manufactured by Pfizer
Sourced in China, United States
Celecoxib capsules are a pharmaceutical product manufactured by Pfizer. They contain the active ingredient celecoxib, which is a selective COX-2 inhibitor. The capsules are designed for oral administration.
Automatically generated - may contain errors
Lab products found in correlation
Dynastat, by Pfizer (1 mentions)
Colorimetric assay kit, by Cayman Chemical (1 mentions)
Ripa lysis buffer, by Beyotime (1 mentions)
β actin antibody, by ABclonal (1 mentions)
P38 mapk antibody, by Cell Signaling Technology (1 mentions)
Isoflurane, by RWD Life Science (1 mentions)
Carrageenan, by Maclin Biochemical Technology (1 mentions)
Phosphatase inhibitor cocktail, by Beyotime (1 mentions)
Hrp goat anti rabbit igg h l, by ABclonal (1 mentions)
Sapk jnk antibody, by Cell Signaling Technology (1 mentions)
Phospho sapk jnk antibody, by Cell Signaling Technology (1 mentions)
Phenylmethylsulfonyl fluoride pmsf, by Beyotime (1 mentions)
Trios 3, by 3Shape (1 mentions)
Dexamethasone (dex), by Merck Group (1 mentions)
Formic acid, by Merck Group (1 mentions)
7 protocols using celecoxib capsule
1
Perioperative NSAID Celecoxib Protocol
2
Celecoxib for Osteoarthritis Pain
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Patients in the celecoxib group will orally take a celecoxib capsule (approval number J20030098, manufactured by Pfizer Pharmaceutical Co. Ltd., Beijing, China) at a daily dosage of 200 mg for 2 weeks. Patients in the placebo group will receive a placebo capsule (manufactured by pharmacy department of Affiliated Hospital of Chengdu University of TCM) with oral administration at the same dosage as celecoxib capsule once a day for 2 weeks. The placebo capsule is identical in appearance, smell, and texture to the celecoxib capsule. Patients in the waiting list group will be observed for 2 weeks without any medical or other interventions. After 2 weeks’ observation, patients in the waiting list group and placebo group could choose either 2 weeks’ celecoxib treatment or acupuncture treatments free of charge.
3
Sulfasalazine and Celecoxib for Rheumatoid Arthritis
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The control group receives basic treatment; sulfasalazine combined with celecoxib will be used. Sulfasalazine enteric-coated tablets (manufactured by Shanghai Zhongxisunve Pharmaceutical Co., Ltd.; national medicine permission number (NMPN:H31020557)) 1.0 g b.i.d. po; in combination with celecoxib capsule (repacked by Pfizer Pharmaceuticals; NMPN: J20140072) 200 mg q.d. po. The treatment group receives thunder-fire moxibustion three times a week plus basic treatment.
4
Investigating COX Enzyme Activity
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Acetic acid and formalin were purchased from El-Gomhouria for trading Pharmaceuticals, Chemicals and Medical Appliances, Alexandria, Egypt. Celecoxib capsules from Pfizer Pharmaceutical Company, Alexandria, Egypt, and neostigmine ampoules from Amriya Pharmaceutical industries, Alexandria, Egypt, and diclofenac sodium ampoules from NOVARTIS, Alexandria, Egypt were used in the experiment. All ELISA kits were purchased from MyBioSource, San Diego, USA. The activities of Cox-1 and Cox-2 were determined using colorimetric assay kit (Cayman Chemical Company; Ann Arbor, MI, USA).
5
Anti-inflammatory Mechanisms in Carrageenan-Induced Mice
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Male KM mice, weighing
16–18 g, were purchased from the Animal Laboratory Centre of
Jinzhou Medical University (Animal license number: SCXK [Liao] 2019-0007).
YXB (NO: 20210303) was supplied by China Resources in Liaoning Benxi
Third Pharmaceutical Co., Ltd. Celecoxib Capsules (Cele) (NO: DK1011)
were purchased from Pfizer. Carrageenan (NO: C804872) was purchased
from Shanghai Macklin Biochemical Co., Ltd. Isoflurane (NO: R510-22)
was purchased from RWD Life Science Co., Ltd. RIPA lysis buffer (NO:
P0013B), phosphatase inhibitor cocktail (NO: P1081), and phenylmethylsulfonyl
fluoride (PMSF) (NO: ST506) were purchased from Beyotime Biotechnology.
A Pierce Rapid Gold BCA Protein Assay Kit (NO: A53227) was purchased
from Thermo Scientific. SAPK/JNK Antibody (NO: 9252), Phospho-SAPK/JNK
Antibody (NO: 9251), and p38 MAPK Antibody (NO: 8690) were purchased
from Cell Signaling Technology. p-p38 Antibody (NO: WLP1576), ERK1/2
Antibody (NO: WL02371), p-ERK1/2 Antibody (NO: WLP1512), NF-κB
p65 Antibody (NO: WL01273b), p-NF-κB p65 Antibody (NO: WL02169),
and COX-2 Antibody (NO: WL01750) were purchased from Wanleibio Co.,
Ltd. β-actin Antibody (NO: AC026) and HRP Goat Anti-Rabbit IgG
(H + L) (NO: AS014) were purchased from ABclonal. An Ultra-High Sensitivity
ECL Kit (NO: BL523A) was purchased from Biosharp. Mouse TNF-α,
IL-1β, and IL-6 ELISA kits were purchased from R&D.
16–18 g, were purchased from the Animal Laboratory Centre of
Jinzhou Medical University (Animal license number: SCXK [Liao] 2019-0007).
YXB (NO: 20210303) was supplied by China Resources in Liaoning Benxi
Third Pharmaceutical Co., Ltd. Celecoxib Capsules (Cele) (NO: DK1011)
were purchased from Pfizer. Carrageenan (NO: C804872) was purchased
from Shanghai Macklin Biochemical Co., Ltd. Isoflurane (NO: R510-22)
was purchased from RWD Life Science Co., Ltd. RIPA lysis buffer (NO:
P0013B), phosphatase inhibitor cocktail (NO: P1081), and phenylmethylsulfonyl
fluoride (PMSF) (NO: ST506) were purchased from Beyotime Biotechnology.
A Pierce Rapid Gold BCA Protein Assay Kit (NO: A53227) was purchased
from Thermo Scientific. SAPK/JNK Antibody (NO: 9252), Phospho-SAPK/JNK
Antibody (NO: 9251), and p38 MAPK Antibody (NO: 8690) were purchased
from Cell Signaling Technology. p-p38 Antibody (NO: WLP1576), ERK1/2
Antibody (NO: WL02371), p-ERK1/2 Antibody (NO: WLP1512), NF-κB
p65 Antibody (NO: WL01273b), p-NF-κB p65 Antibody (NO: WL02169),
and COX-2 Antibody (NO: WL01750) were purchased from Wanleibio Co.,
Ltd. β-actin Antibody (NO: AC026) and HRP Goat Anti-Rabbit IgG
(H + L) (NO: AS014) were purchased from ABclonal. An Ultra-High Sensitivity
ECL Kit (NO: BL523A) was purchased from Biosharp. Mouse TNF-α,
IL-1β, and IL-6 ELISA kits were purchased from R&D.
6
Dental Implant Placement and Restoration
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Following materials and instruments have been used in this study: Nikon D90 SLR camera (Nikon Co., Ltd., Japan), Trios 3 (3Shape, Denmark), CBCT (KaVo, Germany), Geomagic Studio 2013 (Geomagic, USA), Geomagic qualify 2013 (Geomagic, USA), Minimally invasive elevator (Luxator, Sweden), Ankylos implant (Dentsply Sirona, Germany), Nobel Active implant and temporary titanium abutment (Nobel Biocare, Sweden), Bio-oss bone powder (Geistlich Pharma AG, Switzerland), 3M Z350 flow resin (3M Company, USA), DMG Luxatemp star temporary crown material (DMG, Germany), 1.7 mL × 1 dose of articaine epinephrine injection (ACTEON, France), Amoxicillin capsules 0.5 g × 24 tablets (Federal Pharmaceutical Company, China), Roxithromycin 0.15 g × 12 tablets (Zhenyuan Pharmaceutical Co., China), Tinidazole 0.5 g × 8 tablets (Hubei Guangji Pharmaceutical Co., Ltd., China), Celecoxib capsules 0.2 g × 6 tablets (Pfizer, USA), Ibuprofen sustained release capsules 0.3 g × 20 tablets (GlaxoSmithKline, UK), and Compound chlorhexidine gargle 500 mL (Jiangsu Chenpai Bond Pharmaceutical Co., Ltd., China).
7
Simultaneous Quantification of Celecoxib, Dezocine, and Dexmedetomidine
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CEL (purity more than 98.0%), DEZ (purity more than 98.0%), and DEX (purity more than 98.0%) were purchased from Sigma-Aldrich Chemical Co. (St. Louis, MO, USA). MDZ (purity more than 98.0%, IS) were obtained from China Academy of pharmaceutical and biological products. Celecoxib capsules (product batch number: DX7405, package lot number: ED5001) were purchased from Pfizer Pharmaceuticals Ltd. Dezocine Injection (product batch number: 18042731) were purchased from Yangtze River Pharmaceutical Group Co., Ltd. DEXmedetomidine Hydrochloride Injection (product batch number: 180222BP) was obtained from Hengrui medicine Co., Ltd. Methanol and acetonitrile of HPLC-grade were provided by Tianjin Kermel Chemical Reagent Co., Ltd. Formic acids were procured from Sigma-Aldrich Chemical Co. (St. Louis, MO, USA).
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