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5 hepe

Manufactured by Cayman Chemical
Sourced in United States

5-HEPE is a lipid compound that can be used for research purposes. It is a hydroxyeicosapentaenoic acid, a type of eicosanoid. The core function of 5-HEPE is to serve as a research tool for studying lipid metabolism and related biological processes.

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2 protocols using 5 hepe

1

Lipid Peroxidation Modulation Protocol

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AA and EPA were obtained from Nacalai Tesque (Kyoto, Japan). 5-HETE, 5-HEPE, and 5-oxo-ETE were purchased from Cayman Chemical (Ann Arbor, MI, USA). Both tertiary butylhydroquinone (tBHQ) and special grade methanol (MeOH) were purchased from Wako (Osaka, Japan). Alpha-tocopherol and tertiary butylhydroperoxide (TBHP) were obtained from Sigma-Aldrich (St. Louis, MO, USA) and Tokyo Chemical Industry Co., Ltd. (Tokyo, Japan), respectively.
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2

EPA Metabolites and Inhibitors Protocol

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Highly purified EPA (purity: 98%) ethyl ester was provided by Mochida Pharmaceutical Co., Ltd., which is used in animal and clinical studies27 (link). EPA metabolites (5-HEPE, 12-HEPE, 15-HEPE, 17(18)-EpETE and prostaglandin D3) were purchased from Cayman chemical. Inhibitors for EPA metabolism (Zileuton, Etodolac and Baicalein) and PSN375963 and TUG-891 were purchased from Sigma-Aldrich. GPR119 antagonist TM43718 was purchased as E897-0145 from ChemDiv (San Diego, CA, USA).
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