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Ssr149415

Manufactured by Sanofi
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Sourced in France

SSR149415 is a laboratory equipment product. It is a chemical compound that can be used in various research and analytical applications. The core function of SSR149415 is to serve as a tool for scientific investigation, without any specific interpretation or extrapolation on its intended use.

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Lab products found in correlation

Mecamylamine, by Merck Group (1 mentions) Nicotine, by Merck Group (1 mentions) Pentobarbital, by Merck Group (1 mentions) Bromodeoxyuridine (brdu), by Merck Group (1 mentions) Phorbol 12 myristat 13 acetate pma, by Merck Group (1 mentions) Ddavp, by Bachem (1 mentions)

2 protocols using ssr149415

1

Pharmacological Modulation of V1b Receptors

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Nicotine, mecamylamine, and pentobarbital were purchased from Sigma-Aldrich (St. Louis, MO, USA) and dissolved in sterile saline (0.9% sodium chloride). The V1b receptor antagonists SSR149415 ((2S,4R)-1-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3- dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide, isomer (−); Sanofi, Paris, France)[36 (link)] was dissolved in a mixture of dimethyl sulfoxide (DMSO) (5% v/v), Cremophor EL (5% v/v), and saline. Drug doses are expressed as salt with the exception of the Nicotine dose which is expressed as free base.
Qi X., Guzhva L., Ji Y, & Bruijnzeel A.W. (2015). Chronic treatment with the vasopressin 1b receptor antagonist SSR149415 prevents the dysphoria associated with nicotine withdrawal in rats. Behavioural brain research, 292, 259-265.
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2

Chemical Procurement for Research

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Most standard chemicals were purchased from Sigma (St. Louis, MO), Roche Molecular Biochemicals (Mannheim, Germany), or Merck and Co. (Darmstadt, Germany) unless otherwise indicated. Bromodeoxyuridine (BrdU) and phorbol 12-myristat 13-acetate (PMA) were from Sigma (Lisle d'Abeau Chesne, France). G € o6976 was from Merck Chemistry (Fontenay-sous-Bois, France). AVP and dDAVP were from Bachem (Bubendorf, Switzerland). SSR49059, SSR121463B, SSR126768A, and SSR149415 were kindly provided by Sanofi (Toulouse, France).
Hus-Citharel A., Bouby N., Corbani M., Mion J., Mendre C., Darusi J., Tomboly C., Trueba M., Serradeil-Le Gal C., Llorens-Cortes C, & Guillon G. (2021). Characterization of a functional V1B vasopressin receptor in the male rat kidney: evidence for cross talk between V1B and V2 receptor signaling pathways. American journal of physiology. Renal physiology, 321(3).
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