Aldh1l1 cre ert2 mice

All experiments were approved by the Vanderbilt University Institutional Animal Care and Use Committees and were conducted in accordance with the National Institute of Health guidelines for the Care and Use of Laboratory Animals. 5–16 week-old male and female C57BL/6J mice obtained from Jackson Labs or bred in-house and were used for experiments throughout the manuscript. 10–18 week-old male and female Cnr1^flx/flx mice bred in-house were used for experiments in Figure 3. Aldh1l1-Cre/ERT2 mice and Ai95D mice were obtained from Jackson Labs and crossed in-house to obtain Aldh1l1-Cre:Ai95D mice. 10–18 week-old male and female Aldh1l1-Cre:Ai95D mice were used for experiments in Figure 3. SOM-IRES-Cre mice and Ai14 mice were obtained from Jackson labs and crossed in-house to obtain SOM:Ai14 mice. 10–20 week-old male and female SOM:Ai14 mice were used for experiments in Figure 2. SOM:Ai14 mice were used over SOM-IRES-Cre mice due to the phenotype observed in homozygous SOM-IRES-Cre mice^{39 (link)} and the availability of this line within our laboratory, as the Ai14 reporter construct should not interfere with our experimental strategy. Sex differences were not a primary analysis variable in this study and no overt sex differences were observed, thus all data are pooled from both sexes.