Copper chloride dihydrate

Manufactured by Merck Group

Sourced in United States

Copper chloride dihydrate is an inorganic compound with the chemical formula CuCl2·2H2O. It is a blue crystalline solid that is soluble in water and other polar solvents. Copper chloride dihydrate is commonly used as a precursor for other copper compounds and in various laboratory applications.

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Close spelling variants of this product

Copper(II) chloride dihydrate (76 citations) Copper chloride (66 citations) Copper (II) chloride dihydrate (CuCl2.2H2O, (10 citations)

16 protocols using copper chloride dihydrate

Antioxidant and Cytotoxic Evaluation of Natural Oils

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Soy lecithin and neem oil were purchased from Galeno srl (Carmignano, Prato, Italy). Sodium hyaluronate was purchased by DSM Nutritional Products AG Branch Pentapharm (Dornacherstrasse 112 CH-4147 Aesch BL/Switzerland). Argan oil, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), gallic acid, ferrous sulphate, 1,1-diphenyl-2-picrylhydrazyl radical (DPPH), (±)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox), 2,4,6-tris(2-pyridyl)-1,3,5-triazine (TPTZ), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), neocuproine (2,9-dimethyl-1,10-phenanthroline) hydrochloride, Folin-Ciocalteu’s reagent, sodium carbonate, ferric chloride, ammonium acetate, copper chloride dihydrate, potassium persulphate, copper sulphate pentahydrate and all the other reagents were of analytical grade and were purchased from Sigma-Aldrich (Milan, Italy). Ultrapure water (18 MΩ·cm) was obtained with a Milli-Q Advantage A10 System apparatus (Millipore, Milan, Italy). Reagents and plastics for cell culture were purchased from Life Technologies Europe (Monza, Italy).

Manca M.L., Manconi M., Meloni M.C., Marongiu F., Allaw M., Usach I., Peris J.E., Escribano-Ferrer E., Tuberoso C.I., Gutierrez G., Matos M, & Ghavam M. (2021). Nanotechnology for Natural Medicine: Formulation of Neem Oil Loaded Phospholipid Vesicles Modified with Argan Oil as a Strategy to Protect the Skin from Oxidative Stress and Promote Wound Healing. Antioxidants, 10(5), 670.

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Synthesis and Characterization of Metal-Organic Composites

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Zinc acetate dihydrate (Zn(CH₃COO)₂·2H₂O, 99.99% purity), copper chloride dihydrate (CuCl₂·2H₂O), polyvinyl alcohol Mowiol 4–88 (88% hydrolysis/MW: 31 kDa), sodium hydroxide (NaOH pellets, ≥97.0%), methanol, D-(+)-glucose, ascorbic acid (AA), uric acid (UA), fructose, sucrose, maltose, and lactose were purchased from Sigma-Aldrich (St. Louis, MO, USA). They were of analytical grade and used as received, without further purification. Distilled water was used for the preparation of all aqueous solutions.

Mahmoud A., Echabaane M., Omri K., Boudon J., Saviot L., Millot N, & Chaabane R.B. (2021). Cu-Doped ZnO Nanoparticles for Non-Enzymatic Glucose Sensing. Molecules, 26(4), 929.

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Radiolabeled RGD Peptide for PET Imaging

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Copper chloride dihydrate (CuCl₂·2H₂O), poly(acrylic acid) (molecular weight, MW, 5000 g/mol), and hydrazine hydrate (50–60%) were purchased from Sigma-Aldrich. Au NMs were purchased from Nanopartz. Amine-poly(ethylene glycol)-thiol (MW 5000 g/mol) was purchased from Nanocs (New York, NY, USA). BS₃ cross-linker was purchased from Thermo Scientific. Arginine-glycine-aspartic acid peptide, c(RGDyK), was bought from Anaspec. 2,2′,2″-(10-(2-((2,5-Dioxopyrrolidin-1-yl)oxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid (DOTA-NHS-ester) was purchased from Fisher Scientific. ⁶⁴Cu was produced by the PET Department, NIH. Deionized (DI) water with a resistivity of 18.0 MΩ was from a Millipore Autopure system. All chemicals were of analytical grade and used without further purification.

Sun X., Huang X., Yan X., Wang Y., Guo J., Jacobson O., Liu D., Szajek L.P., Zhu W., Niu G., Kiesewetter D.O., Sun S, & Chen X. (2014). Chelator-Free 64Cu-Integrated Gold Nanomaterials for Positron Emission Tomography Imaging Guided Photothermal Cancer Therapy. ACS Nano, 8(8), 8438-8446.

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Synthesis of Nanocrystalline Materials

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Cadmium acetate dihydrate (Sigma-Aldrich,
98%), myristic acid (Sigma-Aldrich, 98%), selenium (Se, Sigma-Aldrich,
99.99%), tellurium (Te, SigmaAldrich, 99.99%), copper chloride dihydrate
(ACS reagent, 99.8%), zinc acetate trihydrate (Zn(CH₃COO)₂·2H₂O, Sigma-Aldrich, 98%), sodium borohydride
(NaBH₄, Sigma-Aldrich, 96%), trioctylphosphine (TOP, Sigma-Aldrich,
technical grade, 90%), 1-octadecene (ODE, Sigma-Aldrich, technical
grade, 90%), oleylamine (technical grade, 70%), sulfur (S, Sigma-Aldrich,
<99.5%), oleic acid (technical grade, Sigma-Aldrich, 90%), cadmium
oxide (Sigma-Aldrich, 99.9%), and lead oxide (Alfa Aesar, 99.9%).
Hexane (AR grade, 99%), 1,4-butanediol (90%, AR), dextrose (95% anhydrous,
AR), HCl (99%), and HNO₃ (98%) were purchased from SD Fine
Chemicals. All chemicals were used without further purification.

Mahadevu R, & Pandey A. (2018). Thermodynamic Model for Quantum Dot Assemblies Formed Because of Charge Transfer. ACS Omega, 3(1), 266-272.

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Synthesis of Copper-Cysteamine Nanoparticles

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Copper chloride dihydrate, cysteamine hydrochloride, sodium hydroxide (NaOH), p-nitrosodimethylaniline (RNO), and imidazole (ID) were bought from Sigma-Aldrich, USA.

Sah B., Wu J., Vanasse A., Pandey N.K., Chudal L., Huang Z., Song W., Yu H., Ma L., Chen W, & Antosh M.P. (2020). Effects of Nanoparticle Size and Radiation Energy on Copper-Cysteamine Nanoparticles for X-ray Induced Photodynamic Therapy. Nanomaterials, 10(6), 1087.

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Synthesis of Copper(II) Chloride Dihydrate Derivatives

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Copper chloride dihydrate (CuCl₂.2H₂O), cysteamine hydrochloride, sodium hydroxide (NaOH), polyethylene glycol 4000, dihydrorhodamine 123 (DHR), dihydroethidium (DHE) and coumarin were bought from Sigma-Aldrich, USA. All the chemicals were used as received.

Chang Y., Wu F., Pandey N.K., Chudal L., Xing M., Zhang X., Nguyen L., Liu X., Liu J.P., Chen W, & Pan Z. (2020). Combination of Disulfiram and Copper–Cysteamine Nanoparticles for an Enhanced Antitumor Effect on Esophageal Cancer. ACS applied bio materials, 3(10), 7147-7157.

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Chemical Treatments for Balsa Wood

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Balsa wood (O. pyramidale) of density 102 ± 5 kg/m³ was bought from Material
AB, Sweden. Samples of dimensions 15 × 15 × 5 mm³ (tangential × radial × axial) were cut for chemical treatment.
Sodium chlorite (NaClO₂, 80%), sodium hydroxide (NaOH,
≥98%), copper chloride dihydrate (CuCl₂·2H₂O, ≥99.0%), ethylenediaminetetraacetic acid (EDTA,
[(CH₂COOH)₂NCH₂]₂, 99.4–100.6%),
boric acid (H₃BO₃, ≥99.5%), and (dimethylamino)borane
(DMAB, (CH₃)₂NHBH₃, ≥97%)
were bought from Sigma-Aldrich, Sweden, and ethanol (96%) was bought
from VWR, Sweden.

Xu X., Garemark J., Ram F., Wang Z, & Li Y. (2024). Metallic Wood through Deep-Cell-Wall Metallization: Synthesis and Applications. ACS Applied Materials & Interfaces, 16(17), 22433-22442.

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Synthesis and Characterization of Multifunctional Nanoparticles

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Cetyltrimethylammonium chloride solution (CTAC), triethanolamine (TEA), tetraethoxysilane (TEOS), sodium citrate (3-mercaptopropyl)-trimethoxysilane (MPTES), concentrated HCl (37%), ammonia aqueous solution (NH₃·H₂O, 25wt %), bis[3-(triethoxysilyl)propyl]tetrasulfide (BTES), sodium sulfide nonahydrate (Na₂S·9H₂O), copper chloridedihydrate (CuCl₂·2H₂O), Gadolinium chloride hexahydrate (GdCl₃·6H₂O) were purchased from Sigma-Aldrich (MO, USA). The C18PMH-mPEG was purchased frommLaysan Bio Inc. (AL, USA). The PBS, DMEN medium, Fetal bovine serum (FBS) and 0.05% trypsin–EDTA were obtained from Gibco Laboratories (NY, USA). Human stomach normal epithelial cells (GES-1), human stomach cancer cells (HGC-27), human lung normal epithelial cells (BEAS-2B), primary spleen cells of mice (spleen cells) and human liver normal epithelial cells (LO2) were acquired from American Type Culture Collection (ATCC).

Guo W., Chen Z., Chen J., Feng X., Yang Y., Huang H., Liang Y., Shen G., Liang Y., Peng C., Li Y., Li G., Huang W., Zhao B, & Hu Y. (2020). Biodegradable hollow mesoporous organosilica nanotheranostics (HMON) for multi-mode imaging and mild photo-therapeutic-induced mitochondrial damage on gastric cancer. Journal of Nanobiotechnology, 18, 99.

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Synthesis of Organic Compounds using Common Reagents

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Analytical grade cobalt chloride hexahydrate (CoCl₂·6H₂O), zinc chloride (ZnCl₂, 99%), and copper chloride dihydrate (CuCl₂·2H₂O) were all bought from Sigma-Aldrich. Mesitylene (98%), tris(4-aminophenyl)amine (98%), 1,3,5-tris(4-aminophenyl)benzene (97%), 4-nitrophthalimide (98%), urea (American Chemical Society reagent, 99%), ethanol (Analytical Reagent, 99.7%), terephthalaldehyde (98%), DTBBQ (99%), acetic acid (99%), 1,4-dioxane (98%), tetrabutylammonium bromide (TBAB), and PO were purchased from Aladdin. 1,2-Epoxyethylbenzene, 2-ethylhexyl glycidyl ether, 4-tert-butylphenyl glycidyl ether, glycidyl phenyl ether, and butyl glycidyl ether were bought from TCI. Ultrapure water (18 megohms) was supplied using a Millipore system (Millipore Q). All the chemicals were used without further purification.

Zhang X., Liu H., An P., Shi Y., Han J., Yang Z., Long C., Guo J., Zhao S., Zhao K., Yin H., Zheng L., Zhang B., Liu X., Zhang L., Li G, & Tang Z. (2020). Delocalized electron effect on single metal sites in ultrathin conjugated microporous polymer nanosheets for boosting CO2 cycloaddition. Science Advances, 6(17), eaaz4824.

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Synthesis of Copper Oxalate Compounds

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All the abovementioned
chemicals
were of analytical grade and were used without any further purification.
Copper chloride dihydrate (CuCl₂·2H₂O),
sodium hydroxide (NaOH), and oxalic acid dihydrate were all purchased
from Sigma-Aldrich, Korea. During experiments, deionized water was
used to make up aqueous solutions of various components.

Nazim M., Khan A.A., Asiri A.M, & Kim J.H. (2021). Exploring Rapid Photocatalytic Degradation of Organic Pollutants with Porous CuO Nanosheets: Synthesis, Dye Removal, and Kinetic Studies at Room Temperature. ACS Omega, 6(4), 2601-2612.

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