Prisma mri scanner

An MRI examination was applied using a 3T Siemens Prisma MRI scanner equipped with a standard 20-channel head coil. The detailed scanning protocol was described in previous studies [29 (link),36 (link)] and comprised the following pulse sequences: a sagittal 3D T1 magnetization-prepared rapid acquisition gradient echo sequence; a contrast-enhanced, T1-weighted turbo inversion recovery magnitude dark-fluid sequence; a T2-weighted TIRM dark-fluid scan, as well as a fluid attenuation inversion recovery sequence. In addition, RS-fMRI was implemented using echo planar imaging.

For the present study, an MRI data set previously obtained and published [23 (link)] was used for the analyses. The detailed scanning protocol is therefore described in detail elsewhere [3 (link),10 (link),23 (link)] and comprised the following pulse sequences: a sagittal 3D T1 magnetization-prepared rapid acquisition gradient echo (MPRAGE) sequence; a contrast-enhanced, T1-weighted turbo inversion recovery magnitude (TIRM) dark-fluid sequence; a T2-weighted TIRM dark-fluid scan; a fluid attenuation inversion recovery (FLAIR); as well as an echo planar imaging (EPI) sequence, including 300 whole-brain functional volumes. Scanning was applied using a 3T Siemens Prisma MRI scanner equipped with a standard 20-channel head coil. (For a more detailed description please see Supplement S1).

Patients’ MRI scans were obtained parallel to the anterior commissure–posterior commissure line using 3.0-T MRI scanners. Of the 145 patients, 57 were scanned using an Achieva scanner (Philips Healthcare, Best, the Netherlands), 35 using a TrioTim scanner (Magnetom Trio, Tim System, Siemens), 36 using a Skyra scanner (Siemens), and 17 using a Prisma MRI scanner (Siemens, Erlangen, Germany). All MRI scans were obtained using T1-weighted magnetization-prepared rapid gradient-echo and fluid-attenuated inversion recovery (FLAIR) sequences. T1-weighted (T1W) scans were obtained with the following parameters: repetition time, 1900 ms; echo time, 2.6 ms; field-of-view, 220 mm; matrix size, 256 × 256; slice thickness, 1 mm; 176 coronal slices without a gap; voxels, 0.86 × 0.86 × 1 mm³; flip angle, 16°; and number of excitations, 1. The FLAIR scans were obtained with following parameters: repetition time, 9000 ms; field-of-view, 220 mm; matrix size, 384 × 278; slice thickness, 4 mm; and 31 coronal slices without a gap.

Subjects lay horizontally in the MR scanner and their arms rested beside their trunk. To reduce head motion, foam pads were placed around the participants’ head and we explicitly instructed participants to avoid head motion.
For 43 patients and 32 healthy controls, the MRI scans were acquired on a 3 T Prisma MRI scanner (Siemens, Germany). The MRI sequences acquired included the following: one T1-weighted MPRAGE scan (8 min 22 s covering 176 sagittal slices, 1 mm thick, TR = 5000 ms, TE = 2.98 ms, flip angle 1 = 4°, flip angle 2 = 5°, voxel size = 1 × 1 × 1 mm), and one rs-fMRI sequence using a multi-band echoplanar 2D (10 min and 11 s covering 600 volumes of 72 slices; 2.5 mm thick, TR = 1000 ms, TE = 37 ms, flip angle = 30°, voxel size = 2.5 × 2.5 × 2.5 mm FOV = 230 × 230 mm, GRAPPA = 1, multiband acceleration factor = 8).
For 46 patients and 44 healthy controls, the MRI scans were acquired on a 3 T TrioTim MRI scanner (Siemens, Germany). The MRI sequences acquired included the following: T1-weighted MDEFT scan (13 min 43 s covering 176 sagittal slices, 1 mm thick, TR = 7.92 ms, TE = 2.48 ms, flip angle = 16°, voxel size 1 × 1 × 1 mm), and one rs-fMRI sequence using a single-band echoplanar 2D (8 min and 40 s covering 256 volumes of 38 slices; TR = 2000 ms, TE = 30 ms, flip angle = 90°, voxel size = 3.6 × 3.6 × 3.0 mm, FOV = 230 × 230 mm, GRAPPA = 2).