Immediately postoperative, anteroposterior, and lateral X-rays were performed to confirm the space between the proximal and distal ends of the tibia. Each experimental group was given radiographic followup at weeks 4, 7, and 10. Five radiographic images of each animal at different observation times were obtained. 3D computerized tomography (CT) scan was performed in postmortem specimens of the injured bones from each animal. The bone segments were arrayed in the experimental groups abs immobilized in vertical position on a cardboard surface and were analyzed with a General Electric Light Speed VCT™ system using the following protocol: 100.0 kV, 100 mA, and 0.6 mm. This study was performed to study bone shapes, transversal structure and density, and bone regeneration.
Lightspeed vct system
Manufactured by GE Healthcare
Sourced in United States
The Lightspeed VCT system is a computed tomography (CT) imaging device designed and manufactured by GE Healthcare. The system utilizes a volume computed tomography (VCT) approach to capture high-resolution, three-dimensional images of the body. The Lightspeed VCT system is capable of rapid image acquisition and data processing to support a variety of clinical applications.
Automatically generated - may contain errors
Lab products found in correlation
6 protocols using lightspeed vct system
1
Radiographic Assessment of Bone Regeneration
2
CT Imaging of Anatomical Structures
3
Quantitative CT Imaging of Pulmonary Vasculature
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Within 30 minutes of MRI examination, CT scans were acquired post-bronchodilator
after inhalation of 1.0 L of nitrogen from functional residual capacity, with
use of a 64-slice Lightspeed VCT system (GE Healthcare; parameters = 64 ×
0.625 collimation, 120 peak kilovoltage, 100 mA, tube rotation time = 500 msec,
pitch = 1.25, standard reconstruction kernel, section thickness = 1.25 mm, field
of view = 40 cm2), as previously described (22 (link)).
Pulmonary vascular measurements included total blood volume, volume of pulmonary
blood vessels of 5 mm2 or smaller (BV5), between 5–10
mm2 (BV5–10), and greater than 10 mm2 (BV10),
as detailed inAppendix
E1 (online). CT data were qualitatively
evaluated by a single chest CT radiologist (M.S.A., with >10 years of
experience) for diagnostic and incidental findings. The qualitative reader was
not blinded. CT data were also quantitatively evaluated by a single experienced
observer (A.M.M., with 4 years of experience) who was blinded to participant
identification and clinical measurements with use of automated software (Chest
Imaging Platform, Brigham and Women’s Hospital) (23 ).
Data generated or analyzed during the study are available from the corresponding
author by request and will be deposited athttps://apilab.ca/our_code.html under data version
20220401.
after inhalation of 1.0 L of nitrogen from functional residual capacity, with
use of a 64-slice Lightspeed VCT system (GE Healthcare; parameters = 64 ×
0.625 collimation, 120 peak kilovoltage, 100 mA, tube rotation time = 500 msec,
pitch = 1.25, standard reconstruction kernel, section thickness = 1.25 mm, field
of view = 40 cm2), as previously described (22 (link)).
Pulmonary vascular measurements included total blood volume, volume of pulmonary
blood vessels of 5 mm2 or smaller (BV5), between 5–10
mm2 (BV5–10), and greater than 10 mm2 (BV10),
as detailed in
E1
evaluated by a single chest CT radiologist (M.S.A., with >10 years of
experience) for diagnostic and incidental findings. The qualitative reader was
not blinded. CT data were also quantitatively evaluated by a single experienced
observer (A.M.M., with 4 years of experience) who was blinded to participant
identification and clinical measurements with use of automated software (Chest
Imaging Platform, Brigham and Women’s Hospital) (23 ).
Data generated or analyzed during the study are available from the corresponding
author by request and will be deposited at
20220401.
4
CT Brain Scans for Traumatic Injury
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The CT scans were acquired using a GE LightSpeed VCT system with a voxel resolution of 0.488 mm × 0.488 mm (512 × 512 voxel matrix). Axial slices (44 to 64) were obtained, with slice thickness ranging from 2 mm to 5 mm. Every patient underwent three CT brain scans at intervals of 3 (T=), 30 (T1), and 90 (T2) days following the brain injury (Figure 1 ).
5
Hyperpolarized Gas MRI and CT Ventilation Imaging
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All imaging was completed at the Robarts Research Institute (Western University, London, Canada). 1H and inhaled hyperpolarised gas (3He and/or 129Xe) MR images (3×3×15 mm3) were acquired within 5 min of one another using a 3T MR system (General Electric Health Care, Milwaukee, WI, USA) as previously described [23 (link)]. For all acquisitions, participants were coached to inhale 1 L of gas from functional residual capacity (FRC), and coronal slices were acquired under breath-hold conditions at FRC+1 L. Thoracic computed tomography (CT) was performed at a similar lung volume using a 64-slice Lightspeed VCT system (GE Healthcare) as previously described [23 (link)]. Quantitative MRI analysis was performed by a single trained observer who was blinded to intervention allocation (MM) using semi-automated segmentation and registration software to generate the MRI ventilation defect per cent (VDP) at baseline [31 (link)]. The observer segmented each baseline MRI dataset twice (coefficient of variation 14.9%; intraclass correlation coefficient 0.97, 95% CI 0.93–0.99), and the mean VDP of the two rounds was reported.
6
Multi-Modal Pulmonary Imaging Protocol
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Anatomical proton ( 1 H) and hyperpolarised 3 He ventilation magnetic resonance images were acquired within 5 min of one another using a 3T MRI system (General Electric Healthcare, Milwaukee, WI, USA), as previously described [24] . Subjects were instructed to inhale 1.0 L of gas (100% N 2 for 1 H MRI and a 3 He/N 2 mixture for 3 He MRI) from FRC, and coronal images were acquired under breath-hold conditions. He gas was polarised to 40% (Polarean; HeliSpin, Durham, NC, USA) and diluted with nitrogen gas to 5 mL per kilogram of body weight.
Thoracic computed tomography (CT) volumes were acquired with a 64-slice Lightspeed VCT system (General Electric Healthcare, Milwaukee, WI, USA) with subjects in breath-hold after inhalation of 1.0 L of nitrogen gas from FRC as previously described [25] . Using the manufacturer's settings and the ImPACT CT patient dosimetry calculator (based on the UK Health Protection Agency NRPB-SR250 software), the total effective dose was 1.8 mSv.
Thoracic computed tomography (CT) volumes were acquired with a 64-slice Lightspeed VCT system (General Electric Healthcare, Milwaukee, WI, USA) with subjects in breath-hold after inhalation of 1.0 L of nitrogen gas from FRC as previously described [25] . Using the manufacturer's settings and the ImPACT CT patient dosimetry calculator (based on the UK Health Protection Agency NRPB-SR250 software), the total effective dose was 1.8 mSv.
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