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Prisma mr scanner

Manufactured by Siemens
Sourced in Germany

The Prisma MR scanner is a magnetic resonance imaging (MRI) system manufactured by Siemens. It is designed to acquire high-quality images of the human body for medical diagnostics and research purposes. The Prisma MR scanner utilizes powerful superconducting magnets, advanced radiofrequency (RF) technology, and innovative software to generate detailed images of the body's internal structures.

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23 protocols using prisma mr scanner

1

MRI Scan for PET Data Co-Registration

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One structural MRI scan was performed in each subject using a 3 Tesla PRISMA MR Scanner (Siemens Medical, 0.85- x 0.87-mm voxel size, 0.85-mm slice thickness, 230 slices) for co-registration of PET data.
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2

Simultaneous CEST-SAGE-EPI Acquisition for pH and R2*

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Simultaneous acquisition of pH-sensitive information and relaxometry measures of R2′ were performed through modification of a previously described CEST EPI sequence (16 (link)) to include a SAGE-EPI readout (Fig 2). The SAGE-EPI readout consisted of two gradient echoes (TE1=14.0ms;TE2=34.1ms), an asymmetric spin echo (TE3=58.0ms), and a spin echo (TE4=92.4ms). All phantom and human CEST-SAGE-EPI data were acquired with a CEST saturation pulse train consisting of three (3×) 100-ms Gaussian pulses with amplitude B1=6μT, TR>10,000ms, FOV=240×217, matrix size=128×104, partial Fourier encoding =6/8, GRAPPA=3, bandwidth=1630 Hz/pixel, and 25 contiguous slices with a 4mm slice thickness. A total of 29 z-spectral points was acquired with data around +/− 3.0ppm and 0.0ppm with respect to water (from −3.5 to −2.5 in intervals of 0.1; from −0.3 to +0.3 in intervals of 0.1; and from +2.5 to +3.5 in intervals of 0.1). An additional reference S0 scan with identical parameters and no saturation pulse was acquired with NEX=4. The total acquisition time for CEST-SAGE-EPI was 7 minutes and 30 seconds benchmarked on a 3T Siemens Prisma MR scanner (Software Versions VE11A-C; Siemens Healthcare; Erlangen, Germany).
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3

Multimodal Neuroimaging: 3T Siemens Prisma

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Measurements were acquired at Cleveland Clinic Main Campus using 3T Siemens Prisma MR Scanner. T1-weighted anatomical images were obtained from a MPRAGE sequence (FoV = 240 × 256 mm2, 160 slices). FMRI data were obtained from an EPI sequence (TR/TE =2, 800/29 ms, 39 slices, slice thickness = 3.5 mm, 132 volumes). To limit the head motion scans at Cleveland Clinic were acquired with subjects fitted with a bite bar.
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4

High-resolution Multimodal Neuroimaging Protocol

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All imaging data were acquired on a 3T Siemens Prisma MR scanner at the Liverpool Magnetic Resonance Imaging Center (LiM-RIC). Scanning included a T1-weighted magnetization-prepared rapid acquisition gradient echo sequence (MPRAGE; 192 slices, repetition time [TR] = 2000 ms, inversion time [TI] = 912 ms, echo time [TE] = 2.25 ms, resolution = 1.0 × 1.0 × 1.0 mm3, flip angle = 8°, acquisition time = 7:30 min). An FBI sequence (TR = 4400 ms, TE = 100 ms, 46 axial slices, resolution = 2.7 × 2.7 × 2.7 mm3, b-values = 0, 5000 s/mm2, 128 directions) and a standard DKI scan (TR = 3200 ms, TE = 90 ms, 46 axial slices, resolution = 2.7 × 2.7 × 2.7 mm3, b-values = 0, 1000, 2000s/mm2, 60 directions) were also performed.
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5

Multimodal Neuroimaging Protocol for Cognitive Responses

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In experiment 1, responses were collected using a generic keyboard; in the MRI scanner, responses were collected with a standard MR‐compatible button box (Current Designs, 8‐button response device, HHSC‐2x4‐C, Philadelphia, USA). With a 3 Tesla Siemens Prisma MR scanner, structural (high resolution T1‐weighted MPRAGE; isotropic voxel resolution 1 × 1 × 1 mm3; 192 sagittal slices) and functional whole‐brain (Gradient‐Echo‐EPI‐sequence; multiband acceleration factor of 2; TR = 1,000 ms; TE = 29 ms; FOV = 216 mm; flip angle = 62°; distance factor = 15%; 603 volumes per run) images were acquired. Thirty‐two oblique transversal slices of 3.0 × 3.0 × 3.0 mm voxels, tilted 30° relative to the anterior‐posterior commissural plane, were obtained to avoid signal dropout in frontal areas (Deichmann, Gottfried, Hutton, & Turner, 2003).
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6

Multimodal Brain Imaging Protocol

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All patients and controls were scanned at the Liverpool Magnetic Resonance Imaging Centre (LiMRIC) using a 3 T Siemens Prisma MR scanner. Scanning included a T1‐weighted magnetization‐prepared rapid acquisition gradient echo sequence (MPRAGE; 192 slices, repetition time [TR] = 2,000 ms, inversion time [TI] = 912 ms, echo time [TE] = 2.25 ms, resolution = 1.0 × 1.0 × 1.0 mm3, flip angle = 8°, acquisition time = 7:30 min). In order to calculate FBI and FBWM parameters, two diffusion‐weighted scans were performed: (a) an FBI sequence (TR = 4,400 ms, TE = 100 ms, 46 axial slices, resolution = 2.7 × 2.7 × 2.7 mm3, b‐values = 0, 5,000 s/mm2, 128 directions) to calculate ζ and FAA; (b) a DKI sequence that was parameter‐matched to the FBI scan (b‐values = 0, 1,000, 2000 s/mm2, 30 directions) which, along with the FBI scan, allows for the calculation of Da, MDe, De,⊥, De,II, FAE, and AWF. A standard DKI scan was also performed in order to calculate standard DTI metrics of FA and MD (TR = 3,200 ms, TE = 90 ms, 50 axial slices, resolution = 2.5 × 2.5 × 2.5 mm3, b‐values = 0, 1,000, 2,000 s/mm3, 64 directions).
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7

Structural MRI Acquisition: Prisma 3T Scanner

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Neuroimaging data were acquired using a 3 Tesla Prisma MR Scanner (Siemens Medical Systems, Erlangen, Germany) located in the Medical Faculty of RWTH Aachen University. T1-weighted structural images were acquired by means of a 3-dimensional magnetization-prepared rapid acquisition gradient echo imaging sequence (4.12 min; 176 slices, TR = 2300 ms, TE = 1.99 ms, TI = 900 ms, FoV = 256 × 256 mm2, flip angle = 9°, voxel resolution = 1 × 1 × 1 mm3). All images were inspected for structural abnormalities, scanner artifacts, and motion artifacts. In case of the latter two, imaging acquisition was repeated.
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8

High-resolution Multimodal Neuroimaging Protocol

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All imaging data were acquired on a 3T Siemens Prisma MR scanner at the Liverpool Magnetic Resonance Imaging Center (LiM-RIC). Scanning included a T1-weighted magnetization-prepared rapid acquisition gradient echo sequence (MPRAGE; 192 slices, repetition time [TR] = 2000 ms, inversion time [TI] = 912 ms, echo time [TE] = 2.25 ms, resolution = 1.0 × 1.0 × 1.0 mm3, flip angle = 8°, acquisition time = 7:30 min). An FBI sequence (TR = 4400 ms, TE = 100 ms, 46 axial slices, resolution = 2.7 × 2.7 × 2.7 mm3, b-values = 0, 5000 s/mm2, 128 directions) and a standard DKI scan (TR = 3200 ms, TE = 90 ms, 46 axial slices, resolution = 2.7 × 2.7 × 2.7 mm3, b-values = 0, 1000, 2000s/mm2, 60 directions) were also performed.
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9

Resting-state fMRI Protocol for Brain Imaging

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Resting-state functional MRI (rs-fMRI) data were collected prior to task-based fMRI (which is not part of the present report; see previous paragraph) on a 3-T Siemens Prisma MR-Scanner equipped with a 32-channel head coil, using a multiband (MB factor = 4) EPI sequence with the following parameters: 900 volumes (10:14 min), TR = 675 ms, TE = 30 ms, voxel size = 3 mm3, flip angle = 60°, FoV = 222 mm, acquisition matrix = 74 × 74, 40 slices. During the rs-fMRI measurement, participants were asked to keep their eyes open and gaze at a white fixation cross, located at the center of a screen (Nordic Neuro Lab, 40″, 1,920 × 1,080, 60 Hz), to stay relaxed and not to think about anything specific. In a separate session, a T1 weighted (T1w) 3D structural MR scan was acquired with a MPRAGE sequence (4:26 min, voxel size = 1 mm3, TR = 1,900 ms, TE = 2.52 ms, acquisition matrix = 256 × 256, 192 slices) for purposes of coregistration between functional and structural data.
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10

Multimodal Brain Imaging for Amyloid Deposition

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All participants underwent 18F‐florbetapir PET as well as 3.0T multimodal brain MRI. The interval between the two imaging examinations did not exceed 1 month. 18F‐florbetapir PET was scanned using Biograph 128 mCT, Siemens, Germany and uPMR790 TOF, Untied Imaging, China. Intravenous injection of 18F‐florbetapir 7.4 MBq/kg was administered according to the subject's body mass, and brain PET/CT visualization was performed after 50 min of quiet rest.10‐s low‐dose head CT scan at one bed position.20‐min brain PET scan in 3D mode; PET image reconstruction using filtered inverse projection; MR scan using a 3.0T Siemens Prisma MR scanner, Germany; T1 structural imaging using Magnetization Prepared Rapid Gradient Echo imaging (MPRAGE).
Postacquisition images were visually assessed using FBP reconstruction. Reconstructed 18F‐florbetapir PET images were visually analyzed by an intermediate (W.‐Y.W.) and a senior PET diagnostician (J.‐J.G.). In the case of disagreement, a third senior diagnostician (F.X.or C.‐T.Z.) made the judgment. Based on the distribution of cortical Aβ deposits, the diagnostic results were categorized as positive and negative (Figure S2).
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