N vanillylnonanamide

Manufactured by Merck Group

Sourced in United States

N-vanillylnonanamide is a chemical compound used as a laboratory reagent. It is a derivative of vanillyl alcohol and nonanoic acid. The compound can be used in various applications in the field of analytical chemistry and biochemistry.

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Lab products found in correlation

Acetonitrile, by Thermo Fisher Scientific (2 mentions) Methanol, by Thermo Fisher Scientific (2 mentions) Epigallocatechin 3 gallate, by Merck Group (1 mentions) Antibodies against phospho p38, by Cell Signaling Technology (1 mentions) Antibodies against iκbα, by Santa Cruz Biotechnology (1 mentions) Cy3 conjugated secondary antibody, by Santa Cruz Biotechnology (1 mentions) Horseradish peroxidase, by Santa Cruz Biotechnology (1 mentions) Recombinant human il 1β, by Thermo Fisher Scientific (1 mentions) β tubulin, by Santa Cruz Biotechnology (1 mentions) N acetylcysteine, by Merck Group (1 mentions) β glucuronidase from bovine liver, by Merck Group (1 mentions) Sodium acetate, by Thermo Fisher Scientific (1 mentions) D saccharic acid 1 4 lactone monohydrate, by Merck Group (1 mentions) Lc ms grade water, by Thermo Fisher Scientific (1 mentions) Ascorbic acid, by Merck Group (1 mentions) Ionomycin calcium salt, by Merck Group (1 mentions) Allyl isothiocyanate, by Merck Group (1 mentions) Dimethyl sulfoxide (dmso), by Thermo Fisher Scientific (1 mentions) Go6983, by Bio-Techne (1 mentions) Bms345541, by Bio-Techne (1 mentions)

4 protocols using n vanillylnonanamide

Molecular Signaling Pathway Modulators

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(-)-epigallocatechin-3-gallate (EGCG), N-acetylcysteine (NAC), and N-vanillylnonanamide (NVN) were obtained from Sigma Aldrich Co. Ltd. (St. Louis, MO). Recombinant human IL-1β was purchased from GIBCO BRL (Grand Island, NY). The inhibitors, BAY 11–7085 for NF-κB, SB 203580 for p38, and PD 98059 for MEK 1, were purchased from Calbiochem (La Jolla, CA). EGCG and NAC were dissolved in H₂O. NVN, BAY 11–7085, SB 203580, and PD 98059 were dissolved in dimethyl sulfoxide, methyl alcohol, or H₂O. The final vehicle concentration was adjusted to 0.1% (v/v), and the control medium contained the same quantity of vehicle. Antibodies against phospho-p38, p38, phospho-ERK, and ERK were obtained from Cell Signaling Technology (Beverly, MA). Antibodies against IκBα, β-tubulin, horseradish peroxidase, and Cy3-conjugated secondary antibodies were obtained from Santa Cruz Biotechnology (Santa Cruz, CA).

Lee J.Y., Paik J.S., Yun M., Lee S.B, & Yang S.W. (2016). The Effect of (-)-Epigallocatechin-3-Gallate on IL-1β Induced IL-8 Expression in Orbital Fibroblast from Patients with Thyroid-Associated Ophthalmopathy. PLoS ONE, 11(2), e0148645.

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Ginger Compounds Quantification Protocol

Cited 1 time

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The ginger capsules and the corresponding placebos were a gift provided and manufactured by Pure Encapsulations LLC (Sudbury, MA). The ginger capsules contain 6.55% 6G, 0.94% 8G, 1.88% 10G, 2.21% 6S, 0.37% 8S, and 0.95% 10S. β-Glucuronidase from bovine liver, sulfatase from Helix pomatia, d-saccharic acid 1,4-lactone monohydrate (β-glucuronidase inhibitor), ascorbic acid, and N-vanillylnonanamide (internal standard, IS) were purchased from Sigma-Aldrich Inc. (St Louis, MO, USA). Sodium acetate was purchased from Fisher Scientific. All ginger standard compounds were previously purified or synthesized in our lab.^{27 (link),28 (link)} Their purities were as follows: 6G, 97.0%; 8G, 96.2%; 10G, 97.0%; 6S, 97.6%; 8S, 96.3%; 10S, 95.5%; 6G-diol-2, 95.7%; M2, 99.1%; M9, 99.1%; M11, 96.2%. Acetonitrile, methanol, and water (LC–MS grade) were purchased from Thermo Fisher Scientific (Waltham, MA). Other general chemicals were purchased from VWR (Radnor, PA).

Zhang S., DiMango E., Zhu Y., Saroya T.K., Emala C.W, & Sang S. (2022). Pharmacokinetics of Gingerols, Shogaols, and Their Metabolites in Asthma Patients. Journal of agricultural and food chemistry, 70(31), 9674-9683.

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Synthesis and Characterization of LJO-328 Compound

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N

-(4-tert-butylbenzyl)-

N

-(1-[3-fluoro-4-(methylsulfonylamino)phenyl]ethyl)thiourea (LJO-328) was provided by J. Lee of Seoul National University. The structure has been published.^{29 (link)} 2-Mercaptoethanol,

n

-vanillylnonanamide (nonivamide; a capsaicin analog), allyl isothiocyanate (AITC), ionomycin calcium salt, and phorbol 12-myristate 13-acetate (PMA) were from Sigma-Aldrich. Dimethyl sulfoxide (DMSO) was from Fisher Scientific. BMS-345541 and Go6983 were from Tocris, and recombinant human tumor necrosis factor-alpha (

TNF α

), interleukin-1 alpha (

interleukin 1 lowercase alpha

interleukin 1 lowercase beta

, IL6, and IL13 were from Peprotech. 4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole (PD169316) was from Cayman Chemical.

Rapp E., Lu Z., Sun L., Serna S.N., Almestica-Roberts M., Burrell K.L., Nguyen N.D., Deering-Rice C.E, & Reilly C.A. (2023). Mechanisms and Consequences of Variable TRPA1 Expression by Airway Epithelial Cells: Effects of TRPV1 Genotype and Environmental Agonists on Cellular Responses to Pollutants in Vitro and Asthma. Environmental Health Perspectives, 131(2), 027009.

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Nociceptive Pain Induction Techniques

Cited 2 times

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Under 2% isoflurane anesthesia, a 30 G needle was inserted into the plantar surface of the paw subcutaneously. Fifty microlitres of BiTox (200 ng in 0.9% NaCl solution) or vehicle or 50 μL of CFA (Complete Freund's adjuvant, SIGMA, Gillingham, United Kingdom) were injected for more than 10 to 20 seconds. Fifty microlitres of 2% formalin or 10 μL of 0.3% capsaicin N-vanillylnonanamide (synthetic capsaicin; SIGMA) were injected without anesthesia. For the latter, the animal was lightly restrained in a glove during injection. Ten microlitres CFA was injected into the lateral ankle joint. For dose–response experiments, the concentrations of BiTox used were: 2, 50, 100, and 200 ng. All BiTox injections were given in center of the plantar surface unless otherwise stated.^{19 (link),26 (link)}

Mangione A.S., Obara I., Maiarú M., Geranton S.M., Tassorelli C., Ferrari E., Leese C., Davletov B, & Hunt S.P. (2016). Nonparalytic botulinum molecules for the control of pain. Pain, 157(5), 1045-1055.

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