Amorolfine hydrochloride

Manufactured by Merck Group

Sourced in United Kingdom

Amorolfine hydrochloride is a chemical compound used as a pharmaceutical ingredient. It is a synthetic antifungal agent.

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Lab products found in correlation

Terbinafine hydrochloride, by Merck Group (2 mentions) Formic acid, by Thermo Fisher Scientific (1 mentions) Acetonitrile, by Thermo Fisher Scientific (1 mentions) Caffeine, by Merck Group (1 mentions) Fluconazole, by Merck Group (1 mentions) Fenpropimorph, by Merck Group (1 mentions) Efinaconazole, by Merck Group (1 mentions) Caffeine d9, by LGC (1 mentions) Duloxetine hydrochloride, by Merck Group (1 mentions) Benzethonium chloride, by Merck Group (1 mentions) Mouse cxcl2 mip 2 quantikine elisa kit, by R&D Systems (1 mentions) Mouse ifn γ quantikine elisa kit, by R&D Systems (1 mentions)

Spelling variants of this product

Amorolfine (2 citations) Hydrochlorides (2 citations)

3 protocols using amorolfine hydrochloride

Antifungal Compound Quantification Protocol

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Caffeine, fluconazole, efinaconazole, amorolfine hydrochloride, terbinafine hydrochloride, fenpropimorph and flutriafol pestanal were obtained from Sigma Aldrich Ltd, UK. Caffeine-d9 and terbinafine-d7 were purchased from Toronto Research Chemicals, Canada. Acetonitrile and formic acid were purchased from Fisher Scientific, Loughborough, UK, and ultra-pure water from VWR, UK.

Davies-Strickleton H., Cook J., Hannam S., Bennett R., Gibbs A., Edwards D., Ridden C., Ridden J, & Cook D. (2020). Assessment of the nail penetration of antifungal agents, with different physico-chemical properties. PLoS ONE, 15(2), e0229414.

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Characterization of Pharmaceutical Compounds

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Amorolfine hydrochloride (IUPAC name (2R,6S)-2,6-dimethyl-4-[2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine;hydrochloride);
Benzethonium chloride (IUPAC name benzyl-dimethyl-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]azanium;chloride);
Duloxetine hydrochloride (IUPAC name (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine;hydrochloride);
were purchased from Sigma Aldrich (cat. Y0001795, B8879, PHR1865 respectively).

De Mario A., Tosatto A., Hill J.M., Kriston-Vizi J., Ketteler R., Vecellio Reane D., Cortopassi G., Szabadkai G., Rizzuto R, & Mammucari C. (2021). Identification and functional validation of FDA-approved positive and negative modulators of the mitochondrial calcium uniporter. Cell Reports, 35(12), 109275.

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Antifungal Efficacy Evaluation Protocol

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LCZ was kindly provided by Nichino Service Co., Ltd. Liranaftate (LNF) was purchased from Santa Cruz Biotechnology, Inc. Terbinafine hydrochloride (TBF) and amorolfine hydrochloride (AMO) were purchased from Sigma‐Aldrich. Other reagents used were as follows: TPA (Sigma‐Aldrich); PC (Tokyo Chemical Industry Co., Ltd); mouse CXCL1/KC Quantikine^® enzyme‐linked immunosorbent assay (ELISA) kit, mouse CXCL2/MIP‐2 Quantikine^® ELISA kit and mouse IFN‐γ Quantikine^® ELISA kit (R&D Systems Inc); and Fluoro MPO™ Fluorescent Myeloperoxidase Detection Kit (Cell Technology).

Nakamura A., Uratsuji H., Yamada Y., Hashimoto K., Nozawa N, & Matsumoto T. (2019). Anti‐inflammatory effect of lanoconazole on 12‐O‐tetradecanoylphorbol‐13‐acetate‐ and 2,4,6‐trinitrophenyl chloride–induced skin inflammation in mice. Mycoses, 63(2), 189-196.

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