We evaluated the effect of a representative 5‐HT3 receptor antagonist, tropisetron, on A549 and H1792. Cells were seeded at 4 × 104 per well in 12‐well plates and incubated for 24 hours. Next, 40 or 80 μmol/L (A549) and 80 μM (H1792) tropisetron hydrochloride (Tocris Bioscience) was added and cells were incubated for 72 hours (A549) and 96 hours (H1792). Cell proliferation was assayed by the Muse Cell Analyzer.
Tropisetron hydrochloride
Manufactured by Bio-Techne
Tropisetron hydrochloride is a pharmaceutical compound used in research and laboratory settings. It is a selective serotonin 5-HT3 receptor antagonist. The core function of tropisetron hydrochloride is to inhibit the activity of the 5-HT3 receptor, which is involved in various physiological processes.
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Lab products found in correlation
Serotonin hydrochloride, by Merck Group (1 mentions)
Tryptamine hydrochloride, by Merck Group (1 mentions)
Pargyline hydrochloride, by Merck Group (1 mentions)
Fluoxetine hydrochloride, by Merck Group (1 mentions)
Ch223191, by Merck Group (1 mentions)
3 methylindole, by Merck Group (1 mentions)
Asenapine maleate, by Bio-Techne (1 mentions)
Actinomycin d, by Merck Group (1 mentions)
2 protocols using tropisetron hydrochloride
1
Tropisetron Inhibits A549 and H1792 Cell Proliferation
2
Serotonin pathway modulators protocol
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Serotonin hydrochloride, fluoxetine hydrochloride, pargyline hydrochloride, actinomycin D, CH-223191, 3-methylindole, tryptamine hydrochloride, and 3′,4′-dimethoxyflavone were obtained from Sigma. Asenapine maleate, tropisetron hydrochloride, and 6-formylindolo[3,2b]carbazole were obtained from Tocris. 7-ethoxyresorufin was obtained from Santa-Cruz.
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