Molecular structures of the materials (API’s, polymers, and biradical polarizing agents) used in our study are shown in Figure 1 . Copovidone Kollidon VA64, an amorphous random copolymer of 1-viny-2-pyrrolidone and vinyl acetate (60:40 mass ratio and 45–70 kDa molecular weight), was obtained from BASF. vinyl acetate (VA) was purchased from Polymer Source, Inc. The API clotrimazole and posaconazole were products of Spectrum Chemical Inc. and Merck Research Laboratories (MRL), respectively. TOTAPOL39 (link) and AMU-Pol40 are biradical polarizing agents and were both evaluated to enhance MAS NMR signal intensities. TOTAPOL was available from Dynupol, Inc., and AMUPOL was a gift from and Dr. Olivier Ouari and Prof. Paul Tordo (Aix-Marseille Université). Methanol (HPLC grade from Sigma-Aldrich) was used as a solvent for the spray-drying process. All chemicals were used as received.
Copovidone kollidon va64
Manufactured by BASF
Sourced in Germany
Copovidone (Kollidon VA64) is a synthetic polymer used as an excipient in pharmaceutical formulations. It functions as a binder, disintegrant, and solubilizer in solid dosage forms. The product is a white to slightly yellowish, hygroscopic, amorphous powder with a wide range of molecular weights.
Automatically generated - may contain errors
Lab products found in correlation
Vinyl acetate, by BASF (1 mentions)
Hplc grade, by Merck Group (1 mentions)
Sodium lauryl sulfate, by Merck Group (1 mentions)
Eupatilin, by Merck Group (1 mentions)
Poloxamer p407, by BASF (1 mentions)
Polyethylene glycol 300 peg300, by Merck Group (1 mentions)
Brain heart infusion broth, by BD (1 mentions)
Glycerol, by BASF (1 mentions)
Resazurin sodium, by Merck Group (1 mentions)
Methyl thiazolyl tetrazolium (mtt), by Thermo Fisher Scientific (1 mentions)
Mannitol salt agar, by Merck Group (1 mentions)
4 protocols using copovidone kollidon va64
1
Optimizing NMR Signal Intensity with Biradicals
2
Formulation Development of Eupatilin Tablets
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Standardized ethanol extract of A. asiatica and commercialized IR tablet dosage forms of DA-9601 were provided by Dong-A Pharmaceutical Co. Ltd. Eupatilin (purity over 99% w/w) hydrochloride and sodium lauryl sulfate were purchased from Sigma-Aldrich Co. (St Louis, MO, USA). Copovidone (Kollidon VA64) and poloxamer P407 were kindly provided by BASF Co. Ltd. (Ludwigshafen, Germany). Hydroxypropyl methylcellulose (HPMC K4M) was obtained from Shin-Etsu Chemical Co. (Tokyo, Japan). Microcrystalline cellulose (Avicel® PH 101) was obtained from Asahi Kasei (Tokyo, Japan). All other chemicals used were of reagent grade and were used without further purification.
3
Formulation and Evaluation of Piroxicam Delivery
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Piroxicam was purchased from Chr. Olesen Pharmaceuticals A/S (Gentofte, Denmark).
Polyvinyl alcohol 26-88 (PVA, Mw 160000) was obtained from Merck (Darmstadt, German) and polyvinylpyrrolidone 360 (PVP, Mw 360000) were purchased from Sigma-Aldrich (Schnelldorf, German). Poloxamer (Pluronic F127) was purchased from Sigma-Aldrich (Saint Louis, USA). Polyethylene glycol 300 (PEG300) and hydroxypropyl methylcellulose (HPMC, 15 Cps) were received from Sigma-Aldrich (Steinheim, German). Copovidone (Kollidon VA64) was purchased from BASF (Ludwigshafen, Germany). Distilled water was used in all experiments. All solvents used were of HPLC grade with the purity≥99.8%.
Polyvinyl alcohol 26-88 (PVA, Mw 160000) was obtained from Merck (Darmstadt, German) and polyvinylpyrrolidone 360 (PVP, Mw 360000) were purchased from Sigma-Aldrich (Schnelldorf, German). Poloxamer (Pluronic F127) was purchased from Sigma-Aldrich (Saint Louis, USA). Polyethylene glycol 300 (PEG300) and hydroxypropyl methylcellulose (HPMC, 15 Cps) were received from Sigma-Aldrich (Steinheim, German). Copovidone (Kollidon VA64) was purchased from BASF (Ludwigshafen, Germany). Distilled water was used in all experiments. All solvents used were of HPLC grade with the purity≥99.8%.
4
Comparative Analysis of Topical Antiseptic Formulations
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PVP-I, I 2 and polyethylene glycol 400 (PEG 400) were obtained from Srichand United Dispensary (Thailand). Commercial PVP-I solution (Siribuncha ® ) was obtained from Siribuncha Co. Ltd. (Thailand). Iodine spray made in house (1 % iodine available) was compared with PVP-I spray in X-ray photoelectron spectroscopy. Copovidone (Kollidon ® VA64) and glycerol were purchased from BASF (Germany) and the PC Drug Center, Bangkok, Thailand respectively. Ethanol (absolute) and HFA 134a propellant were purchased from V.S. Chem. House (Thailand) and Mexichem (UK), respectively. Mannitol salt agar was obtained from Merck (Germany). Brain heart infusion (BHI) broth was obtained from Becton, Dickinson and Company (USA). Resazurin sodium was obtained from Sigma-Aldrich (USA) and MTT was purchased from Invitrogen TM , Thermo Fisher Scientific (Germany).
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